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| 1 | Significant association between ABO blood group and pancreatic cancer显示文摘AIM:To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United States.METHODS:Using the University of Pittsburgh's clinicalpancreatic cancer registry,the blood donor database from our local blood bank (Central Blood Bank),and the blood product recipient database from the regional transfusion service (Centralized Transfusion Service) in Pittsburgh,Pennsylvania,we identified 274 pancreatic cancer patients with previously determined serological ABO blood group information.The ABO blood group frequency was compared between these patients and 708842 individual,community-based blood donors who had made donations to Pittsburgh's Central Blood Bank between 1979 and 2009.RESULTS:The frequency of blood group A was statistically significantly higher amongst pancreatic cancer patients compared to its frequency amongst the regional blood donors [47.63% vs 39.10%,odds ratio (OR)=1.43,P=0.004].Conversely,the frequency of blood group O was significantly lower amongst pancreatic cancer patients relative to the community blood donors (32.12% vs 43.99%,OR=0.60,P=0.00007).There were limited blood group B (n=38) and AB (n=17) pancreatic cancer patients;the overall P trend value comparing patient to donor blood groups was 0.001.CONCLUSION:The ABO blood group is associated with pancreatic cancer risk.Future studies should examine the mechanism linking pancreatic cancer risk to ABO blood group. | Julia B Greer Mark H Yazer Jay S Raval M Michael Barmada Randall E Brand David C Whitcomb | 2010 | World Journal of Gastroenterology2010，16，44： | 10 |
| 2 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 3 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 4 | 1997 CEO perspectives on the current status and future prospects of the third party logistics industry in the United States显示文摘 | Lieb R C Randall H L | 1999 | Transportation Journal1999，，3： | 1 |
| 5 | Demonstration of hormesis (increase in fatality rate)by penicillin显示文摘 | Randall W A Price C W Welch H | 1947 | American Journal of Public Health and the Nations Health1947，37，4： | 1 |
| 6 | Phase relations and dielectric properties in the Bi2O3-ZnO-Ta2O5 system显示文摘 | YOUN H J SOGABE T RANDALL C A | 2001 | J Am Ceram Soc2001，84，11： | 1 |
| 7 | Nitrate versus Oxygen Respiration in the Activated Sludge Process显示文摘 | McClintock S A Sherrard J H Novak J T Randall C W | 1988 | Journal WPCF1988，60，3： | 1 |
| 8 | A comparison of the use of third party logistics services by large American manufacturers显示文摘 | Lieb R C Randall H L | 1996 | Journal of Business Logistics1996，17，1： | 1 |
| 9 | Differential diagnosis of spaU vs cracks in the gear tooth fillet region: Experimental validation显示文摘 | Endo H Randall R B Gosselin C | 2009 | Mechanical Systems and Signal Processing2009，23，3： | 1 |
| 10 | A Comparison of the Use of Third Party Logistics Services by Large American Manufacturers显示文摘 | LIEB R C RANDALL H L | 1996 | Journal of Business Logistics1996，17，1： | 1 |
| 11 | Differential Diagnosis of Spall Versus Cracks in the Gear Tooth Fillet Region 显示文摘 | Endo H Randall R B Gosselin C | 2004 | Journal of Failure Analysis and Prevention2004，4，5： | 1 |
| 12 | Nitrate versus oxygen respiration in the activated sludge process显示文摘 | McClintock S A Sherrard J H Novak J T Randall C W | 1988 | J WPCF1988，60，3： | 1 |
| 13 | The dose -response relation of intrathecal fentanyl for labor analgesia 显示文摘 | CRAIG M RANDALL C RICHARD H | 1998 | Anesthesiology1998，88，： | 1 |
| 14 | Cognitive functioning in community dwelling older adults with chronic partial epilepsy显示文摘 | Roy C Martin H Randall Griffith | 2005 | Epilepsia2005，46，2： | 1 |
| 15 | Novel cholesterol lowering polymeric drugs obtained by molecular imprinting 显示文摘 | Randall H - F S Harry M Huval C C | 2001 | Macromolecules2001，34，6： | 1 |
| 16 | Soil Thermal conductivity: effects of density, moisture, salt concentration and organic matter显示文摘 | Nidal H A Randall C R | 2000 | Soil Sci Soc Am J2000，64，： | 1 |
| 17 | Carvedilol-liposome interaction:evi-dence for strong association with the hydrophobic region of the lipid bilayers显示文摘 | Cheng H Y Randall C S Holl W W | 1996 | Biochem Biophys Acta1996，128，： | 1 |
| 18 | Phase relations and dielectric properties in the Bi2O3-ZnO-Ta2O5 system显示文摘 | Youn H J Sogabe T Randall C A | 2001 | J Am Ceram Soc2001，84，11： | 1 |
| 19 | Dielectric relaxation and microwave dielectric properties of Bi2O3-ZnO-Ta2O5 ceramics显示文摘 | Youn H J Randall C Chen A | | 0，，： | 1 |
| 20 | Phase relations and dielectric properties in the Bi2O3-ZnO-Ta2O5system显示文摘 | YOUN H J SOGABE T RANDALL C A | 2001 | J Am Ceram Soc2001，84，11： | 1 |
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