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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 3 | 转炉二次烟气净化系统显示文摘转炉炼钢过程释放的废气,特别是在加入含有碳氢化合物杂质的低质废钢时,经常会超出传统废气处理系统的抽风和冷却能力。转炉逸散烟气的燃烧有时导致不可控的火焰释放,高烟气温度则引起系统,特别是布袋除尘器的额外损坏。一种由西门子VAI研发的先进废气净化系统能够消除这些问题。通过对工厂设计、转炉兑铁速度的优化来提高操作安全性,缩短冶炼周期。 | A R Hampel 黄建东(译) 王永忠(校) | 2007 | 世界钢铁2007，7，5： | 6 |
| 4 | Caffeic acid phenethyl ester blocks free radical generation and 6-hydroxydopamine-induced neurotoxicity显示文摘 | Ma Z Wei X Fontanilla C Noelker C Dodel R Hampel H Du Y | 2006 | 中国生物学文摘2006，20，10： | 3 |
| 5 | The Association Between Diabetes and Hepatocellular Carcinoma: A Systematic Review of Epidemiologic Evidence显示文摘 | Hashem B. El–Serag Howard Hampel Fariba Javadi | 2006 | Clinical Gastroenterology and Hepatology2006，，3： | 2 |
| 6 | Variants in the Netrin-1 Receptor UNC5C Prevent Apoptosis and Increase Risk of Familial Colorectal Cancer显示文摘 | Marie–May Coissieux Jerneja Tomsic Marie Castets Heather Hampel Sari Tuupanen Nadine Andrieu Ilene Comeras Youenn Drouet Christine Lasset Sandya Liyanarachchi Laetitia Mazelin Alain Puisieux Jean–Christophe Saurin Jean–Yves Scoazec Qing Wang Lauri Aaltone | 2012 | Gastroenterology2012，，6： | 2 |
| 7 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 2 |
| 8 | CSF markers for incipient Alzheimer’s disease显示文摘 | Kaj Blennow Harald Hampel | 2003 | Lancet Neurology2003，，10： | 2 |
| 9 | Rock salt — the mechanical properties of the host rock material for a radioactive waste repository显示文摘 | Udo Hunsche Andreas Hampel | 1999 | Engineering Geology1999，，3： | 2 |
| 10 | Coating of finely dispersed particles by two-fluid nozzle显示文摘 | N. Hampel E. Roydeva A. Buck E. Tsotsas | 2018 | Particuology2018，16，3： | 2 |
| 11 | Compliant Mechanism Synthesis by Using Elastic Similitude显示文摘Compliant mechanisms have several advantages, especially smaller number of elements and therefore less movable joints. The flexural members furthermore allow an integration of special functions like balancing or locking. Especially fiber reinforced materials exhibit a wide range of function integration considering their compliance in passive as well active applications. To take advantage of compliant elements in applications a robust synthesis tool is needed. The synthesis based on topology optimization method or the pseudo rigid body approach leads to complex structures. Considering the use of fiber reinforced material a synthesis approach which leads to less complex structures is more suitable. For building up simple structures, with only one cantilever beam as compliant element(B) a graphical approach using the elastic similitude is the most efficient method. A step-by-step synthesis procedure is presented to synthesize compliant mechanisms with rotatory joints(R) and prismatic joints(P) to develop RRB/PRB- and RPB-linkages. Using the elastic similitude to implement these results into a graphical synthesis algorithm is the innovation part of this paper. It can be shown that this approach leads to a comfortable handling of beam elements during the synthesis, where the two free parameters can be directly coupled to scale and fix the orientation of the beam element. This advantage inherently shortens the development process. In giving an example the focus lies of the experimental approach, which also shows that the simple BERNOULLI beam model is valid and so the synthesis by using the elastic similitude. The method is presented and discussed by using an application for a cup holder mechanism made of fiber reinforced material. | HANKE Uwe HAMPEL Peter COMSA Andrei MODLER Niels MODLER Karl-Heinz | 2015 | Chinese Journal of Mechanical Engineering2015，28，4： | 2 |
| 12 | Acute toxicity of LAS homologues in marine microalgae : esterase activity and inhibition growth as endpoints of toxicity 显示文摘 | HAMPEL M MORENO G I SOBRINO C | 2001 | Ecotoxicol Environ Safety2001，48，： | 1 |
| 13 | Value of CSF β-amyloid1- 42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment 显示文摘 | Hampel H Teipel Fuchsberger | 2004 | Molecular Psychiatry2004，9，： | 1 |
| 14 | Replica- rive senescence of human endothelial cells in vitro involves G, arrest, Polyploization and senescence- associated apoptosis 显示文摘 | Wanger M Hampel B Bernhard D | 2001 | gxp Gerontol2001，36，8： | 1 |
| 15 | Discriminant power of combined cerebrospinal fluid tau protein and of the soluble interleukin-6 receptor complex in the diagnosis of Alzheimer's disease显示文摘 | Hampel H Teipel SJ Padberg F | | Brain Research0，，： | 1 |
| 16 | Skin tissue engineering--in vivo and in vitro applications显示文摘 | Groeber F Holeiter M Hampel M | 2012 | Clin Plast Surg2012，39，1： | 1 |
| 17 | Changes in deceleration capacity of heart rate and heart rate variability induced by ambient air pollution in individuals with coronary artery disease 显示文摘 | Schneider A Hampel R Ibald-Mulli A | 2010 | Part Fibre Toxicol2010，7，： | 1 |
| 18 | Epigenetic PTEN silencing in malignant melanomas without PTEN mutation显示文摘 | Zhou XP Gimm O Hampel H | 2000 | Am J Pathol2000，157，： | 1 |
| 19 | Urologic complications of spinal cord injury显示文摘 | Selzman AA Hampel N | 1993 | Urol Clin North Am1993，20，： | 1 |
| 20 | Modulation of bladder alphal-adrenergic receptor subtype expression by bladder outlet obstruction 显示文摘 | HAMPEL C DOLBER P C SMITH M R | 2002 | J Urol2002，167，2： | 1 |
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