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| 1 | Cyclooxygenase-2 and the inflammogenesis of breast cancer显示文摘Cohesive scientific evidence from molecular, animal, and human investigations supports the hypothesis that constitutive overexpression of cyclooxygenase-2(COX-2) is a ubiquitous driver of mammary carcinogenesis, and reciprocally, that COX-2 blockade has strong potential for breast cancer prevention and therapy. Key findings include the following:(1) COX-2 is constitutively expressed throughout breast cancer development and expression intensifies with stage at detection, cancer progression and metastasis;(2) essential features of mammary carcinogenesis(mutagenesis, mitogenesis, angiogenesis, reduced apoptosis, metastasis and immunosuppression) are linked to COX-2-driven prostaglandin E2(PGE-2) biosynthesis;(3) upregulation of COX-2 and PGE-2 expression induces transcription of CYP-19 and aromatase-catalyzed estrogen biosynthesis which stimulates unbridled mitogenesis;(4) extrahe-patic CYP-1B1 in mammary adipose tissue converts paracrine estrogen to carcinogenic quinones with mutagenic impact; and(5) agents that inhibit COX-2 reduce the risk of breast cancer in women without disease and reduce recurrence risk and mortality in women with breast cancer. Recent sharp increases in global breast cancer incidence and mortality are likely driven by chronic inflammation of mammary adipose and upregulation of COX-2 associated with the obesity pandemic. The totality of evidence clearly supports the supposition that mammary carcinogenesis often evolves as a progressive series of highly specific cellular and molecular changes in response to induction of constitutive overexpression of COX-2 and the prostaglandin cascade in the 'inflammogenesis of breast cancer'. | Randall E Harris Bruce C Casto Zachary M Harris | 2014 | World Journal of Clinical Oncology2014，5，4： | 15 |
| 2 | Significant association between ABO blood group and pancreatic cancer显示文摘AIM:To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United States.METHODS:Using the University of Pittsburgh's clinicalpancreatic cancer registry,the blood donor database from our local blood bank (Central Blood Bank),and the blood product recipient database from the regional transfusion service (Centralized Transfusion Service) in Pittsburgh,Pennsylvania,we identified 274 pancreatic cancer patients with previously determined serological ABO blood group information.The ABO blood group frequency was compared between these patients and 708842 individual,community-based blood donors who had made donations to Pittsburgh's Central Blood Bank between 1979 and 2009.RESULTS:The frequency of blood group A was statistically significantly higher amongst pancreatic cancer patients compared to its frequency amongst the regional blood donors [47.63% vs 39.10%,odds ratio (OR)=1.43,P=0.004].Conversely,the frequency of blood group O was significantly lower amongst pancreatic cancer patients relative to the community blood donors (32.12% vs 43.99%,OR=0.60,P=0.00007).There were limited blood group B (n=38) and AB (n=17) pancreatic cancer patients;the overall P trend value comparing patient to donor blood groups was 0.001.CONCLUSION:The ABO blood group is associated with pancreatic cancer risk.Future studies should examine the mechanism linking pancreatic cancer risk to ABO blood group. | Julia B Greer Mark H Yazer Jay S Raval M Michael Barmada Randall E Brand David C Whitcomb | 2010 | World Journal of Gastroenterology2010，16，44： | 10 |
| 3 | Update on the natural history of intracranial atherosclerotic disease: A critical review显示文摘Intracranial atherosclerotic disease (ICAD) contributes to a significant number of ischemic strokes. There is debate in the recent literature concerning the impact of the location of stenosis in ICAD on outcome. Some reports have suggested that disease processes and outcomes vary by vessel location, potentially altering the natural history and indications for intervention. Here we have performed a comprehensive, critical review of the natural history of ICAD by vessel in an attempt to assess the differences in disease specific to each of the vascular territories. Our assessment concludes that only minor differences exist between patients with different vessels affected in vessel-specific ICAD. We have found that middle cerebral artery disease confers a lower mortality than vessel-specific ICAD in other intracranial vessels, asymptomatic disease follows a more benign course than symptomatic disease, andthat plaque progression or the detection of microemboli on transcranial Doppler may predict poor outcome. Given the expanding indications for treatment of ICAD and rapidly developing endovascular techniques to confront this disease, a thorough understanding of the natural history of ICAD aids the interventional neuroradiologist in determining when to treat and how to predict outcome in this patient population. | Ricardo J Komotar Christopher P Kellner Daniel M Raper Dorothea Strozyk Randall T Higashida Philip M Meyers | 2010 | World Journal of Radiology2010，2，5： | 8 |
| 4 | Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling:Influence of smoking显示文摘瞄准:为了调查一个模糊逻辑模型是否能预言肤色,表面的癌症(CRC ) 风险由在世袭 non-polyposis 肤色吸表面的癌症(HNPCC ) 病人产生了。方法:从 Creighton 大学世袭癌症研究所登记的 340 个 HNPCC 失配修理(MMR ) 变化搬运人为当模特儿被选择。年龄依赖者曲线被产生阐明开发 CRC 的概率上的在基因变化(hMLH1 或 hMSH2 ) 之间的联合效果,性,和吸烟地位。结果:在男 hMSH2 变化搬运人的吸烟显著地增加的 CRC 风险(P <
0.05 ) 。hMLH1 变化为男性相对 hMSH2 变化搬运人扩充了 CRC 风险(P <
0.05 ) 。男性们非为 hMLH1 比女性有 CRC 的显著地更高的风险吸烟者(P <
0.05 ) , hMLH1 吸烟者(P <
0.1 ) 并且 hMSH2 吸烟者(P <
0.1 ) 。以在在男性的 hMSH2 的一种剂量依赖者方式的吸烟支持的 CRC (P <
0.05 ) 。有 hMSH2 变化的女性和与 hMLH1 组一起的两性仅仅在广泛的吸烟历史以后表明了吸烟效果(P <
0.05 ) 。结论:由在 HNPCC 病人吸烟的 CRC 提升依赖于基因变化,性和年龄。这些数据证明模糊建模可以启用临床的风险分数的明确的表达,从而允许 CRC 预防策略的 individualization。 | Rhonda M Brand David D Jones Henry T Lynch Randall E Brand Patrice Watson Ramesh Ashwathnayaran Hemant K Roy | 2006 | World Journal of Gastroenterology2006，12，28： | 5 |
| 5 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 6 | Nanophase and superfine cemented carbides processed by powder injection molding显示文摘 | Yang Mu-Jen M German Randall | 1998 | Int J of Refractory Metals & Hard Materials1998，16，： | 2 |
| 7 | MRI-based measurement of hippocampal volume in patients with ccrnhat- related posttraumatic stress disorder显示文摘 | BREMNER J D RANDALL P SCOTT T M | 1995 | Am J Psychiatry1995，152，7： | 2 |
| 8 | Seismic restrainer design methods for simply supported bridges显示文摘 | Saiidi M Randall M Maragakis E | 2001 | Journal of Bridge Engineering ASCE2001，6，5： | 1 |
| 9 | Variations on effectiveness of barks as scavengersfor heavy metal ions显示文摘 | Randall J M | 1977 | Forest Product Journal1977，27，11： | 1 |
| 10 | Synthesis of Vinyl Polymer-silica Colloidal Nanocomposites Prepared Using Commercial Alcoholic Silica Sols显示文摘 | Percy M J Amalvy J I Randall D P | 2004 | Langmuir2004，20，： | 1 |
| 11 | Resolution to a conflict regarding blasting near a high pressure pipeline 显示文摘 | WHEELER Randall M | 2012 | Journal of Ex- plosives Engineering2012，29，1： | 1 |
| 12 | Nanoindentation analysis as a two dimensional tool for mapping the mechanical properties of complex surfaces 显示文摘 | Randall N X Vandamme M ULM F-J | 2009 | J Mater Res2009，24，3： | 1 |
| 13 | Nonnegativity, Monotonicity or convexity preserving cubic and quintic Hermite interpolation 显示文摘 | Randall L Edelman A Hyman J M | 1989 | Math of Computation1989，52，： | 1 |
| 14 | Observations on swollen head syndrom in broiler and broiler breeder chickens显示文摘 | Pattison M Chettle N Randall C J | 1989 | Vet Rec1989，125，： | 1 |
| 15 | A Model for Thermal ProPerties of Liquid-Phase SinteredComposites显示文摘 | Randall M German | 1993 | Metallurgical TransactionA1993，，： | 1 |
| 16 | Electronic properties of small neutral and charged beryllium clusters 显示文摘 | Andrew M Kolchin Randall W Hall | 2000 | J Chem Phys2000，113，： | 1 |
| 17 | LSD:A fast line segment detector with a false detection control显示文摘 | Gioi R G V Jakubowicz J Morel J M Randall G | 2010 | IEEE Transactions on Pattern Analysis and Machine Intelligence2010，32，4： | 1 |
| 18 | Use of the acceleration signal of a gearbox in order to perform angular resampling (with limited speed fluctuation)显示文摘 | BONNARDOT F BADAOUI M RANDALL R B | 2005 | Mechanical Systems and Signal Processing2005，19，4： | 1 |
| 19 | Microwave processing of electroceramic materials and devices显示文摘 | Fang C Y Randal C A Lanagan M T | 2009 | Journal of Electroceramics2009，22，： | 1 |
| 20 | Region Tracking on Level Set Methods显示文摘 | Bertalmio M Sapiro G Randall G | 1999 | IEEE Transactions on Medical Imaging1999，18，5： | 1 |
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