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| 1 | Management of hypertension in primary aldosteronism显示文摘Hypertension causes significant morbidity and mortal-ity worldwide, owing to its deleterious effects on the cardiovascular and renal systems. Primary hyperaldo-steronism(PA) is the most common cause of revers-ible hypertension, affecting 5%-18% of adults with hypertension. PA is estimated to result from bilateral adrenal hyperplasia in two-thirds of patients, and from unilateral aldosterone-secreting adenoma in approxi-mately one-third. Suspected cases are initially screened by measurement of the plasma aldosterone-renin-ratio, and may be confirmed by additional noninvasive tests. Localization of aldostosterone hypersecretion is then determined by computed tomography imaging, and in selective cases with adrenal vein sampling. Solitary adenomas are managed by laparoscopic or robotic re-section, while bilateral hyperplasia is treated with min-eralocorticoid antagonists. Biochemical cure following adrenalectomy occurs in 99% of patients, and hemo-dynamic improvement is seen in over 90%, prompting a reduction in quantity of anti-hypertensive medica-tions in most patients. End-organ damage secondary to hypertension and excess aldosterone is significantly improved by both surgical and medical treatment, asmanifested by decreased left ventricular hypertrophy, arterial stiffness, and proteinuria, highlighting the im-portance of proper diagnosis and treatment of primary hyperaldosteronism. Although numerous independent predictors of resolution of hypertension after adrenalec-tomy for unilateral adenomas have been described, the Aldosteronoma Resolution Score is a validated multifac-torial model convenient for use in daily clinical practice. | Anna Aronova Thomas J Fahey Ⅲ Rasa Zarnegar | 2014 | World Journal of Cardiology2014，6，5： | 11 |
| 2 | Epigenetics of gastroenteropancreatic neuroendocrine tumors:A clinicopathologic perspective显示文摘Gastroenteropancreatic neuroendocrine tumors(GEP-NETs) are a heterogeneous group of rare tumors whose site-specific tumor incidence and clinical behavior vary widely. Genetic alterations associated with familial inherited syndromes have been well defined; however, the genetic profile of sporadic tumors is less clear as their tumorigenesis does not appear to be controlled by classic oncogenes such as P53, RB, or KRAS. Even within GEP-NETs, there are no common oncogenic drivers; for example, DAXX/ATRX mutations are strongly implicated in the tumorigenesis of pancreatic but not small bowel NETs. Accordingly, the dysregulation of epigenetic mechanisms has been hypothesized as a potential regulator of GEPNET tumorigenesis and has become a major focus of recent studies. Despite the heterogeneity of tumor cohorts evaluated in these studies, it is obvious that there are methylation patterns, chromatin remodeling alterations, and microR NA and long non-coding RNA(lncR NA) differential expression profiles that are distinctive of GEPNETs, some of which are correlated with significant differences in clinical outcomes. Several translational studies have provided convincing data identifying potential prognostic biomarkers, and some of these have demonstrated preliminary success as serum biomarkers that can be used clinically. Nevertheless, there are many opportunities to further define the mechanisms by which these epigenetic modifications influence tumorigenesis, and this will provide better insight into their prognostic and therapeutic utility. Furthermore, these findings form the foundation for future studies evaluating the clinical efficacy of epigenetic modifications as prognostic biomarkers, as well as potential therapeutic targets. | Brendan M Finnerty Katherine D Gray Maureen D Moore Rasa Zarnegar Thomas J FaheyⅢ | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 4 |
| 3 | RECFST构件抗弯性能和抗弯承载力计算方法显示文摘文章研究了圆端形椭圆钢管混凝土(round-ended elliptical concrete-filled steel tubular,RECFST)构件的受弯性能。基于有限元方法和圆端形椭圆钢管约束核心混凝土本构关系模型的等效计算方法,建立了纯弯作用下RECFST构件的数值分析模型,考虑了材料非线性、圆端形椭圆截面特征及复杂界面接触等问题;通过分析钢材强度、混凝土强度、径厚比及长短轴比等诸多参数在长、短轴方向上对RECFST构件抗弯承载力的影响规律,揭示了其破坏模式,提出了RECFST构件的抗弯承载力简化计算公式。研究表明,钢材强度越大,径厚比越小,RECFST构件的极限弯矩越大。研究结果可为圆端形椭圆钢管混凝土结构设计和应用提供参考。 | Abdul Rahim RASA 王静峰 沈奇罕 | 2019 | 合肥工业大学学报(自然科学版)2019，42，2： | 3 |
| 4 | Gastroesophageal reflux disease:A review of surgical decision making显示文摘Gastroesophageal reflux disease(GERD) is a very common disorder with increasing prevalence. It is estimated that up to 20%-25% of Americans experience symptoms of GERD weekly. Excessive reflux of acidic often with alkaline bile salt gastric and duodenal contents results in a multitude of symptoms for the patient including heartburn, regurgitation, cough, and dysphagia. There are also associated complications of GERD including erosive esophagitis, Barrett's esophagus, stricture and adenocarcinoma of the esophagus. While first line treatments for GERD involve mainly lifestyle and non-surgical therapies, surgical interventions have proven to be effective in appropriate circumstances. Anti-reflux operations are aimed at creating an effective barrier to reflux at the gastroesophageal junction and thus attempt to improve physiologic and mechanical issues that may be involved in the pathogenesis of GERD. The decision for surgical intervention in the treatment of GERD, moreover, requires an objective confirmation of the diagnosis. Confirmation is achieved using various preoperative evaluations including: ambulatory p H monitoring, esophageal manometry, upper endoscopy(esophagogastroduodenoscopy) and barium swallow. Upon confirmation of the diagnosis and with appropriate patient criteria met, an antireflux operation is a good alternative to prolonged medical therapy. Currently, minimally invasive gastroesophageal fundoplication is the gold standard for surgical intervention of GERD. Our review outlines the many factors that are involved in surgical decisionmaking. We will review the prominent features that reflect appropriate anti-reflux surgery and present suggestions that are pertinent to surgical practices, based on evidence-based studies. | maureen moore cheguevara afaneh daniel benhuri caroline antonacci jonathan abelson rasa zarnegar | 2016 | World Journal of Gastrointestinal Surgery2016，8，1： | 3 |
| 5 | X-linked juvenile retinoschisis: phenotypic and genetic characterization显示文摘Juvenile X-linked retinoschisis(XLRS, MIM#312700) belongs to a group of the vitreoretinal dystrophies. We aimed to describe the phenotype-genotype correlation of three XLRS cases in juveniles with different novel mutations from the Lithuanian population. The patients demonstrated macular retinoschisis and typical cyst-like cavities on spectral-domain optical coherence tomography(SD-OCT) images. The mean central foveal thickness was 569.7 μm. Two patients presented with peripheral retinoschisis. Flash electroretinogram demonstrated a reduced b/a ratio(<1.0) in all patients. RS1(NM_000330.3) gene coding exons Sanger sequencing was performed. RS1 c.599 G>T(p.R200 L) mutation was detected in one case, showing to be pathogenic in silico analysis. c.(92_97) ins C(p.W33 fs) mutation was identified for another patient, indicating the variant is possibly damaging in silico analysis. The third case was identified with a pathogenic mutation c.422 C>G(p.R141 H), HGMD CM981753. These are the first cases of XLRS in the Lithuanian population confirmed by molecular genotyping. Presented patients had a different genotype but similar phenotypic traits. | Rasa Strupaite Laima Ambrozaityte Loreta Cimbalistiene Rimvydas Asoklis Algirdas Utkus | 2018 | International Journal of Ophthalmology(English edition)2018，11，11： | 2 |
| 6 | Comparison of intraocular pressure measurements with different contact tonometers in young healthy persons显示文摘AIM:To analyze the correlation of Goldmann applanation tonometer(GAT),I-Care tonometer and Tono-Pen tonometer results in young healthy persons,and to investigate the influence of central corneal thickness(CCT)on intraocular pressure(IOP)measurements recorded with these tonometers.·METHODS:We conducted a pilot clinical study in 78eyes of 78 subjects aged 22-28 years old(44 women and34 men;mean age 23.8±1.19y).IOP was measured using GAT,I-Care and Tono-Pen tonometers,followed by measurements of CCT.Statistical analysis was performed using SPSS 20.0.·RESULTS:The mean IOPs and standard deviation(±SD)for GAT,I-Care and Tono-Pen were 15.62±2.281 mm Hg,16.29±2.726 mm Hg and 16.32±2.393 mm Hg,respectively.The mean CCT was 555.15±29.648μm.Clear positive correlations between GAT and I-Care,GAT and TonoPen,and I-Care and Tono-Pen tonometers were found(r=0.867,P<0.001;r=0.861,P<0.001;r=0.915,P<0.001,respectively).In comparison between devices,BlandAltman analysis showed a significant mean difference(MD)in the measurements by GAT and I-Care of-0.679 mm Hg and by GAT and Tono-Pen of-0.705 mm Hg(P<0.001),but there was no significant difference between I-Care and Tono-Pe(P>0.05).Both non-gold standard tonometers were affected by CCT;that is,both I-Care and Tono-Pen tonometer values were significantly higher with higher CCT means(>555μm;MD=-1.282,P<0.001;MD=-0.949,P<0.001,respectively)compared with GAT.·CONCLUSION:Both I-Care and Tono-Pen tonometers overestimated IOP compared with the GAT values.Either the I-Care or Tono-Pen tonometer could be used instead of GAT because there was no significant difference between their results.Higher CCT values(>555μm)were associated with overestimated IOP values. | saulius galgauskas rasa strupaite ernesta strelkauskaite rimvydas asoklis | 2016 | International Journal of Ophthalmology(English edition)2016，9，1： | 2 |
| 7 | Impact of Prophylactic Central Neck Lymph Node Dissection on Early Recurrence in Papillary Thyroid Carcinoma显示文摘 | Tracy-Ann Moo Julie McGill John Allendorf James Lee Thomas Fahey Rasa Zarnegar | 2010 | World Journal of Surgery2010，，： | 2 |
| 8 | Composition of fatty acids and lipid classes in bulk products generated during enzymic hydrolysis of cod(Gadusmorhua)by-products显示文摘 | Egidijus D Eva F Rasa S | 2005 | Process Biochemistry2005，40，8： | 1 |
| 9 | Treatment of breast abscesses with ultrasound - guided aspiration and irrigation in the emergency setting显示文摘 | Ozseker B Ozcan UA Rasa K | 2008 | Emerg Radiol2008，15，2： | 1 |
| 10 | The effect of methylene blue on peritoneal adhesion formation显示文摘 | RASA K ERVERDIN KARABULUTZ2 | 2002 | Turt J Gastroe nterol2002，13，2： | 1 |
| 11 | Characteristics of protein fractions generated from hydrolysed cod (Gadus morhua) by-products 显示文摘 | Rasa Slizyte Egidijus Dauksas Eva Falch | 2005 | Process Biochemistry2005，40，： | 1 |
| 12 | Combined treatment with thymosin-alpha1 and low dose interferon-alpha after decarbonizes in advanced melanoma显示文摘 | Rasa C Tersely E Laze F | | 0，，02： | 1 |
| 13 | Enzymatic hydrolysis of cod (Gadus morhua) by-products optimization of yield and properties of lipid and protein fractions显示文摘 | Rasa S Turid R Ivar S | 2005 | Process Biochemistry2005，40，： | 1 |
| 14 | Characterization of novel glucose oxysilane sol-gel electrochemical biosen- sots with copper hexaeyanoferrate mediator 显示文摘 | Rasa Pauliukaite Christopher M A Brett | 2005 | Electro- chim Acta2005，50，2526： | 1 |
| 15 | 显示文摘 | Doina Bica Vekais L Rasa M | 2002 | J Magn Magn Mater2002，252，： | 1 |
| 16 | Shrinkage properties of differently managed clay soils in Finland显示文摘 | Rasa K Horn R Raty M | 2009 | Soil Use Manage2009，25，2： | 1 |
| 17 | Application of Number-Size (N-S) Fractal Model to Quantify of the Vertical Distributions of Cu and Mo in Nowchun Porphyry Deposit (Kerman, Se Iran)显示文摘 | Lili Daneshvar Saein Iraj Rasa Nematolah Rashidnejad Omran Parviz Moarefvand Peyman Afzal Behnam Sadeghi | 2013 | Archives of Mining Sciences2013，，1： | 1 |
| 18 | Development of Electrochemical Oxidase Biosensors Based on Carbon Nanotube-Modified Carbon Film Electrodes for Glucose and Ethanol 显示文摘 | Carla Gouveia-Caridade Rasa Pauliukaite | 2008 | Electrochimica Acta2008，53，： | 1 |
| 19 | Purification and characterization of endo- and exo-inulinase显示文摘 | ALDO M SZLAK | 1989 | Biotechnol Appl Biochem1989，11，： | 1 |
| 20 | Heteroaggregation,repepti-zation and stability in mixtures of oppositely charged colloids显示文摘 | Rasa M Philipse A Meeldijk J | 2004 | Journal of Colloid and Interface Science2004，278，1： | 1 |
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