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| 1 | Nerve growth factor involvement in liver cirrhosis and hepatocellular carcinoma显示文摘AIM: To define NGF (nerve growth factor) and its high- affinity receptor trkANGF presence and distribution in fibrotic liver and in HCC, and to verify if NGF might have a role in fibrosis and HCC. METHODS: Intracellular distribution of NGF and trkANGF were assessed by immunohistochemistry and immuno- electron microscopy in liver specimens from HCC, cirrhosis or both. ELISA was used to measure circulating NGF levels. RESULTS: NGF and trkANGF were highly expressed in HCC tissue, mainly localized in hepatocytes, endothelial and some Kupffer cells. In the cirrhotic part of the liver they were also markedly expressed in bile ducts epithelial and spindle-shaped cells. Surprisingly, in cirrhotic tissue from patients without HCC, both NGF and trkANGF were negative. NGF serum levels in cirrhotic and/or HCC patient were up to 25-fold higher than in controls. CONCLUSION: NGF was only detected in liver tissue with HCC present. Intracellular distribution suggests paracrine and autocrine mechanisms of action. Better definition of mechanisms may allow for therapeutic and diagnostic/prognostic use of NGF. | Guido Rasi Annalucia Serafino Lia Bellis Maria Teresa Lonardo Federica Andreola Manuela Zonfrillo Giovanni Vennarecci Pasquale Pierimarchi Paola Sinibaldi Vallebona Giuseppe Maria Ettorre Eugenio Santoro Claudio Puoti | 2007 | World Journal of Gastroenterology2007，13，37： | 13 |
| 2 | Deficiency in the Asubunit of coagulation-factor-ⅩⅢ:two novel point mutations demonstrate different effects on transcript levels显示文摘 | SYRJALA M RASI V | 1994 | Blood1994，84，： | 1 |
| 3 | Trace compounds of biogas from different biogas production plants 显示文摘 | Rasi S Veijanen A Rintala J | 2007 | Energy2007，32，8： | 1 |
| 4 | Drug policy for an aging population - the European Medicine Agency' s geriatric medicines strategy 显示文摘 | Cerreta F Eichler HG Rasi G | 2012 | N EnglJMed2012，367，21： | 1 |
| 5 | The association of C - reac- tive protein, serum amyloid A and fibrinogen with prevalent coro- nary heart disease baseline findings of the PAIS project显示文摘 | Jousilahti P Salomaa V Rasi V | 2007 | Ather- osclerosis2007，156，： | 1 |
| 6 | Combined treatment with thymosin a l and low-dose interferon alpha after dacarbazine in advanced melanoma显示文摘 | Rasi G Terzoli E Izzo F | 2000 | Melanoma Res2000，10，2： | 1 |
| 7 | Combination therapy in the treatment of chronic viral hepatatitis and prevention of hepatocellular carcinoma 显示文摘 | Rasi G Pierimarchi P Sinibaldi Vallebona P | 2003 | Int Immunopharmacol2003，3，8： | 1 |
| 8 | Efficacy of repeated cycles of chemo-immunotherapy with Thymosin α1 and interleukin-2 after intraperitoneal 5-fluorouracil delivery显示文摘 | Gianfranco Silecchia Enrico Guarino Paola Sinibaldi-Vallebona Pasquale Pierimarchi Angelo Restuccia Erasmo Spaziani Paola Bernard Cynthia Tuthill Enrico Garaci Guido Rasi | 1999 | Cancer Immunology, Immunotherapy1999，，4： | 1 |
| 9 | Anti-tumor effect of combined treatment with thymosin alpha 1 and interlerkin-2 after 5-fluofouracil in liver metastases from colorectal cancer in rats 显示文摘 | Silecchia G Sinibaldi VP | 1994 | Int J Cancer1994，57，5： | 1 |
| 10 | The association of C-reactive protein,serum amyloid a and fibrinogen with prevalent coronary heart disease-baseline findings of the PAIS project显示文摘 | JOUSILAHTI P SALOMAA V RASI V | 2001 | Atherosclerosis2001，156，2： | 1 |
| 11 | Analysis of the chronic lymphocytic leukemia coding genome:role of NOTCH1mutational activation显示文摘 | FABBRI G RASI S ROSSI D | 2011 | J Exp Med2011，208，： | 1 |
| 12 | Combined treatment with thymosin-alapha 1 and low-dose interferon-alapha after ifosfamide in non-small cell lung cancer:a phase-Ⅱcontrolled trial显示文摘 | Salvati F Rasi G Portalone L | 1996 | Anticancer Res1996，16，2： | 1 |
| 13 | Ischemic precondition-ing decreases laparoscopy induced oxidative stress in the liver显示文摘 | Nesek-Adam V Rasi Z Vnuk D | | 0，，2： | 1 |
| 14 | Trace compounds of biogas from different biogas production plants显示文摘 | Rasi S Veijanen A Rintala J | 2007 | Energy2007，32，8： | 1 |
| 15 | Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer显示文摘 | Forsberg LA Rasi C Malmqvist N | 2014 | Nat Genet2014，46，6： | 1 |
| 16 | Combined treatment with thymosin α 1 and low-dose interferon alpha after dacarbazine in advanced melanoma 显示文摘 | Terzoli E Izzo F | 2000 | Melanoma Res2000，10，2： | 1 |
| 17 | Time-resolved fluoroimmunoassay of 5-methyl-2-deoxycytidine employing europium-labeled antigen as tracer显示文摘 | Rasi S uvanto E Vilpo LM | 1998 | J Immunol Methods1998，117，1： | 1 |
| 18 | The association of c-reactive protein,serum amyloid a and fibrinogen with prevalent coronary heart disease--baseline findings of the PAIS project显示文摘 | Jousilahti P Salomaa V Rasi V | 2001 | Atherosclerosis2001，156，2： | 1 |
| 19 | Disruption of BIRC3associates with fludarabine chemorefractoriness in TP53wild-type chronic lymphocytic leukemia显示文摘 | ROSSI D FANGAZIO M RASI S | 2012 | Blood2012，119，： | 1 |
| 20 | Lack of collagen XV im- pairs peripheral nerve maturation and, when combined with lami- nin-411 deficiency, leads to basement membrane abnormalities and sensorimotor dysfunction 显示文摘 | Rasi K Hurskainen M Kallio M | 2010 | J Neurosci2010，30，14： | 1 |
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