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| 1 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 2 | Loss of CD103^+ intestinal dendritic cells during colonic inflammation显示文摘AIM:To investigate possible differences in dendritic cells(DC)within intestinal tissue of mice before and after induction of colitis. METHODS:Mucosal DC derived from intestinal tissue,as well as from mesenteric lymph nodes and spleen,were analyzed by fluorescence activated cell sorting(FACS) analysis.Supernatants of these cells were analyzed for secretion of different pro-and anti-inflammatory cytokines. Immunohistochemistry and immunofluorescence were performed on cryosections of mucosal tissue derived from animals with colitis as well as from healthy mice. RESULTS:It was shown that DC derived from healthy intestinal lamina propria(LP)represented an immature phenotype as characterized by low-level expression of costimulatory cytokines.In contrast to DC from spleen and mesenteric lymph nodes(MLN)that secreted proinflammatory cytokines,LP-DC produced high levels of the anti-inflammatory cytokine IL-10.After induction of mu-rine colitis in a CD4 + CD62L + transfer model or in chronic Dextran sulfate sodium-colitis,a marked increase of activated CD80 + DC could be observed within the inflamed colonic tissue.Interestingly,in contrast to splenic DC,a significant population of DC within MLN and colonic LP expressed the mucosal integrin CD103 which was lost during colitis. CONCLUSION:The constitutive secretion of antiinflammatory cytokines by immature DC within the intestinal LP might regulate the homeostatic balance between mucosal immunity and tolerance.CD103 + DC could mediate this important function. | Ulrike G Strauch Nicole Grunwald Florian Obermeier Sonja Gürster Heiko C Rath | 2010 | World Journal of Gastroenterology2010，16，1： | 2 |
| 3 | Critical evaluation of the literature data on beta-alumina and related phases, 1, Phase equilibria and characterization of beta-alumina phase 显示文摘 | DE VRIES R C RATH W L | 1969 | J Am Ceram Soc1969，52，7： | 1 |
| 4 | Preparation and characterization of nanosize Mn-Zn ferrite显示文摘 | Rath C Sahu K K | 1999 | Jour Magn Magn Mate1999，202，： | 1 |
| 5 | Kinetics of dissolution of sulphide minerals in ferric chloride solution, 1: dissolution of galena, sphalerite and chalcopyrite 显示文摘 | RATH P C PARAMGURU R K JENA P K | 1988 | Trans Inst Min Metall1988，97，： | 1 |
| 6 | Preparation of ti- tanium metal by electrochemical reduction of titanium dioxide显示文摘 | Mohanty J Rath P C Subbaiah T | 2009 | Transactions of the Indian Institute of Metals2009，62，3： | 1 |
| 7 | Role of caveolar compartmentation in endothelium-derived hyperpolarizing factor-mediated relaxation:Ca2+ signals and gap junction function are regulated by caveolin in endothelial cells显示文摘 | Saliez J Bouzin C Rath G | | 0，，08： | 1 |
| 8 | Periodontal ligament cel s cultured under steady-flow environments demonstrate potential for use in heart valve tissue engineering显示文摘 | Martinez C Rath S Van Gulden S | | 0，，3： | 1 |
| 9 | Diffusion and excessvacancy production in Cu-Ni laminates 显示文摘 | MASUMURA R RATH B PANDE C | 2003 | Materials Scienceand Engineering: A2003，346，1： | 1 |
| 10 | Electron microscopic tomography of rat-liver mitochondria and their interaction with the endoplasmic reticulum显示文摘 | Buttle K Rath B K | 1998 | Biofactors1998，8，34： | 1 |
| 11 | Microstructure-dependent coercivity in monodispersed hematite particles显示文摘 | Rath C Sahu K K Kulkarni S D | 1999 | Appl Phys Lett1999，75，26： | 1 |
| 12 | Effect of intermittent activity on broiler production parameters 显示文摘 | Balog J M G R Bayyari N C Rath | 1997 | Poultry Science1997，76，： | 1 |
| 13 | Salvage surgery for reeurrent carcinoma of the hypopharynx and reeonstruetion using jejunal free tissue transfer and peetoralis major muscle pedieled flap显示文摘 | Dubsky P C Stilt A Rath T Kornfehl J | 2007 | Arch Otolaryngol Head Neck Surg2007，133，： | 1 |
| 14 | Local warming at injection site helps alleviate pain after rocuronium administration显示文摘 | Mahajan C Rath G P Bithal P K | 2010 | J Anesth2010，24，6： | 1 |
| 15 | Evaluation of light microscopy to localize the site of haematuria 显示文摘 | Rath B Tumer C Hartly B | 1991 | Arch Dis Child1991，66，3： | 1 |
| 16 | On quiet solesHistoric railway line with advanced track technology显示文摘 | RATH T DULLINGER C | 2012 | ZEV Rail Glasers Annalen2012，136，5： | 1 |
| 17 | Residual stresses in ce- ramic - interlayer - metal joints 显示文摘 | Yu H Y Sanday S C Rath B B | 1993 | Journal of the Ameri- can Ceramic Society1993，76，7： | 1 |
| 18 | Peripheral vascular diseases: an update on endovaseular therapy 显示文摘 | Henry M Rath PC Klonaris C | 2005 | Indian Heart J2005，57，： | 1 |
| 19 | Effect of annealing twins on Hall-Perch relation in polycrystalline materials显示文摘 | PANDE C S RATH B B IMAN M A | 2004 | Mater Sci Eng A2004，367，： | 1 |
| 20 | Trends in red mud utilization-a review 显示文摘 | Paramguru R K Rath P C Misra V N | 2004 | Mineral Processing & Extractive Metal2004，26，1： | 1 |
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