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| 1 | Update on global epidemiology of viral hepatitis and preventive strategies显示文摘Viral hepatitis is one of the major public health concerns around the world but until recently it has drawn little attention or funding from global health policymakers.Every year 1.4 million people die from viral hepatitisrelated cirrhosis and liver cancer.However,the majority of the infected population are unaware of their condition.This population have significant obstacles to overcome such as lack of awareness,vulnerability,increased migration,disease stigma,discrimination,as well as poor health resources,conflict in policy development and program implementation.Despite implementing infection control measures over the last few decades eradication or significant disease reduction remains elusive.This study aims to present the current global prevalence status and examines potential elimination strategies.The information for this research were obtained through a systematic review,published scientific literatures,the official websites of various government organisations,international public health organisations and internationally recognised regulatory bodies over a period of 40 years between 1978 and2018. | Meryem Jefferies Bisma Rauff Harunor Rashid Thao Lam Shafquat Rafiq | 2018 | World Journal of Clinical Cases2018，6，13： | 6 |
| 2 | Hepatitis C virus and neurological damage显示文摘Chronic hepatitis C virus(HCV) infection exhibits a wide range of extrahepatic complications, affecting various organs in the human body. Numerous HCV patients suffer neurological manifestations, ranging from cognitive impairment to peripheral neuropathy. Overexpression of the host immune response leads to the production of immune complexes, cryoglobulins, as well as autoantibodies, which is a major pathogenic mechanism responsible for nervous system dysfunction. Alternatively circulating inflammatory cytokines and chemokines and HCV replication in neurons is another factor that severely affects the nervous system. Furthermore, HCV infection causes both sensory and motor peripheral neuropathy in the mixed cryoglobulinemia as well as known as an important risk aspect for stroke. These extrahepatic manifestations are the reason behind underlying hepatic encephalopathy and chronic liver disease. The brain is an apt location for HCV replication, where the HCV virus may directly wield neurotoxicity. Other mechanisms that takes place by chronic HCV infection due the pathogenesis of neuropsychiatric disorders includes derangement of metabolic pathways of infected cells, autoimmune disorders, systemic or cerebral inflammation and alterations in neurotransmitter circuits. HCV and its pathogenic role is suggested by enhancement of psychiatric and neurological symptoms in patients attaining a sustained virologic response followed by treatment with interferon; however, further studies are required to fully assess the impact of HCV infection and its specific antiviral targets associated with neuropsychiatric disorders. | shilu mathew muhammed faheem sara m ibrahim waqas iqbal bisma rauff kaneez fatima ishtiaq qadri | 2016 | World Journal of Hepatology2016，8，12： | 3 |
| 3 | Notch signalling pathway in development of cholangiocarcinoma显示文摘Cholangiocarcinoma(CCA)comprises of extra-hepatic cholangiocarcinoma and intrahepatic cholangiocarcinoma cancers as a result of inflammation of epithelium cell lining of the bile duct.The incidence rate is increasing dramatically worldwide with highest rates in Eastern and South Asian regions.Major risk factors involve chronic damage and inflammation of bile duct epithelium from primary sclerosing cholangitis,chronic hepatitis virus infection,gallstones and liver fluke infection.Various genetic variants have also been identified and as CCA develops on the background of biliary inflammation,diverse range of molecular mechanisms are involved in its progression.Among these,the Notch signalling pathway acts as a major driver of cholangiocarcinogenesis and its components(receptors,ligands and downstream signalling molecules)represent a promising therapeutic targets.Gamma-Secretase Inhibitors have been recognized in inhibiting the Notch pathway efficiently.A comprehensive knowledge of the molecular pathways activated by the Notch signalling cascade as well as its functional crosstalk with other signalling pathways provide better approach in developing innovative therapies against CCA. | Bisma Rauff Arif Malik Yasir Ali Bhatti Shafiq Ahmad Chudhary Ishtiaq Qadri Shafquat Rafiq | 2020 | World Journal of Gastrointestinal Oncology2020，12，9： | 2 |
| 4 | Probiotic supplementation in the first 6 months of life in at risk Asian infants - effects on eczema and atopic sensitization at the age of 1 year显示文摘 | Soh SE AwM Gerez I Chong YS Rauff M Ng YP | 2009 | Clin Exp Allergy2009，39，4： | 1 |
| 5 | Unusual small intestinal ob- struction in adolescent girls:the abdominal cocoon显示文摘 | FOO KT NG KC RAUFF A et a 1 | 1978 | Br J Surg1978，65，6： | 1 |
| 6 | Unusual small intestinal obstruction in adolescent girls : the abdominal eoeoon显示文摘 | Foo KT Ng KC Rauff A | 1978 | Br J Surg1978，65，1： | 1 |
| 7 | Unusual small intestinal obstruction in adolescent girls: the abdominal cocoon 显示文摘 | Foo KT Ng KC Rauff A | 1978 | Br J Surg1978，65，： | 1 |
| 8 | Unusual small intestinal obstruction in adolescent girls: the abdominal cocoon显示文摘 | Foo KT Ng KC Rauff A | 1978 | Br J Surg1978，65，6： | 1 |
| 9 | Unusual small intestinal obstruction in adolescent girls : the abdominal cocoon 显示文摘 | Foo KT Ng KC Rauff A | 1978 | Br J Surg1978，65，6： | 1 |
| 10 | Unusual small intestinal obstruction in adolescent girl:the abdominal cocoon显示文摘 | Foo K T Ng K C Rauff A | 1978 | Br J Surg1978，64，： | 1 |
| 11 | Unusual small intestinal obstruction in adolescent girls: the abdominal cocoon 显示文摘 | F OO KT NG KC RAUFF A | 1978 | Br J Surg1978，65，6： | 1 |
| 12 | Unusual small intestinal obstruction inadolescent girls:the abdominal cocoon显示文摘 | Foo KT Ng KC Rauff A | 1978 | Br J Surg1978，65，： | 1 |
| 13 | Unusual small intestinal obstruction in adolescent girls : the abdominal cocoon 显示文摘 | Foo KT Ng KC Rauff A | 1978 | Br J Surg1978，65，6： | 1 |
| 14 | Unusual small intestinal obstruction in adolescent girls; The Abdominal cocoon: 显示文摘 | Feo KT Ng KC Rauff A | 1978 | Br J Surg1978，65，3： | 1 |
| 15 | Unusual small intestinal obstruction in adolescent girls :the abdominal cocoon显示文摘 | Foo KT Ng KC Rauff A | 1978 | British Journal of Surgery1978，65，： | 1 |
| 16 | Unusual small intestinal obstruction in adolescent girls:the abdominal cocoon显示文摘 | Foo KT Ng KC Rauff A | 1978 | Br J Surg1978，65，6： | 1 |
| 17 | Unusual small intestinal obstruction adolescent girls:the abdominal cocoon显示文摘 | Ng KC Rauff A | 1978 | Br J Surg1978，65，6： | 1 |
| 18 | Cardiac time intervals of normal fetuses using noninvasive fetal electrocardiography显示文摘 | Chia EL Ho TF Rauff M | 2005 | Prenat Diagn2005，25，： | 1 |
| 19 | Evaluation of the results of a survey of dairy producers on dairy herd biosecurity and vaccination against bovine viral diarrhea显示文摘 | Rauff Y Moore D A Sischo W M | | 0，，09： | 1 |
| 20 | Unusual small intestinal obestruction in adolescent girls: the abdominal cocoon显示文摘 | Foo KT Ng KC Rauff A | 1978 | Br J Surg1978，65，5： | 1 |
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