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| 1 | Same-day 2-L PEG-citrate-simethicone plus bisacodyl vs split 4-L PEG: Bowel cleansing for late-morning colonoscopy显示文摘AIM: To evaluate the efficacy, tolerability, acceptability and feasibility of bisacodyl plus low volume polyethyleneglycol-citrate-simeticone(2-L PEG-CS) taken the same day as compared with conventional split-dose 4-L PEG for late morning colonoscopy. METHODS: Randomised, observer-blind, parallel group, comparative trial carried out in 2 centres. Out patients of both sexes, aged between 18 and 85 years, undergoing colonoscopy for diagnostic investigation, colorectal cancer screening or follow-up were eligible. The PEG-CS group received 3 bisacodyl tablets(4 tablets for patients with constipation) at bedtime and 2-L PEG-CS in the morning starting 5 h before colonoscopy. The control group received a conventional 4-L PEG formulation given as split regimen; the morning dose was taken with the same schedule of the low volume preparation. The Ottawa Bowel Preparation Scale(OBPS) score was used as the main outcome measure.RESULTS: A total of 164 subjects were enrolled and 154 completed the study; 78 in the PEG-CS group and 76 in the split 4-L PEG group. The two groups were comparable at baseline. The OBPS score in the PEG-CS group(3.09 ± 2.40) and in the PEG group(2.39 ± 2.55) were equivalent(difference +0.70; 95%CI:-0.09-1.48). This was confirmed by the rate of successful bowel cleansing in the PEG-CS group(89.7%) and in the PEG group(92.1%)(difference-2.4%; 95%CI:-11.406.70). PEG-CS was superior in terms of mucosa visibility compared to PEG(85.7% vs 72.4%, P = 0.042). There were no significant differences in caecum intubation rate, time to reach the caecum and withdrawal time between the two groups. The adenoma detection rate was similar(PEG-CS 43.6% vs PEG 44.7%). No serious adverse events occurred. No difference was found in tolerability of the bowel preparations. Compliance was equal in both groups: more than 90% of subjects drunk the whole solution. Willingness to repeat the same bowel preparations was about 90% for both regimes. CONCLUSION: Same-day PEG-CS is feasible, effective as split-dose 4-L PEG for late morning colonoscopy and does not interfere with work and daily activities the day before colonoscopy. | Annalisa de Leone Darina Tamayo Giancarla Fiori Davide Ravizza Cristina Trovato Giuseppe De Roberto Linda Fazzini Marco Dal Fante Cristiano Crosta | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，9： | 5 |
| 2 | 星形胶质细胞介导的免疫反应在癫痫发病中的作用显示文摘星形胶质细胞是中枢神经系统中主要的细胞种类之一,在许多疾病过程中参与调节免疫/炎性反应。在癫痫相关病理损伤过程中可观察到星形胶质细胞的活化增殖,其在癫痫发生过程中的病理生理学作用值得我们进一步研究。在癫痫患者的脑组织中,星形胶质细胞的物理特性发生了明显改变,其中一个重要的变化就是星形胶质细胞炎性反应途径的激活。越来越多的研究表明,促炎分子可以改变胶质细胞-神经元之间的通信,导致痫性发作及痫性发作相关的神经元损伤。离体和在体研究均发现星形胶质细胞是致痫炎性信号的主要来源及作用靶点。因此,理解癫痫大脑组织中的星形胶质细胞炎性反应有助于为星形胶质细胞介导的癫痫的靶向干预策略提供新的思路。本文对星形胶质细胞在癫痫内源性免疫反应中的作用进行综述,讨论并评价耐药癫痫患者的临床研究及临床相关模型实验研究的结果,重点关注炎症反应相关通路(如白介素-1β/Toll样受体4),这些通路有可能是抗痫治疗的潜在靶点及疾病调整治疗的新策略。 | ELEONORA ARONICA TERESA RAVIZZA EMANUELE ZUROLO ANNAMARIA VEZZANI | 2012 | 神经损伤与功能重建2012，7，5： | 2 |
| 3 | Antithrombin III (ATILL) replacement therapy in patients with sepsis and/or postsurgical complications: a controlled double-blind, randomized, multicenter study显示文摘 | F. Baudo T. M. Caimi F. deCataldo A. Ravizza S. Arlati G. Casella D. Carugo G. Palareti C. Legnani L. Ridolfi R. Rossi A. D’Angelo L. Crippa D. Giudici G. Gallioli A. Wolfler G. Calori | 1998 | Intensive Care Medicine1998，，4： | 2 |
| 4 | The role of cytokines in the pathophysiology of epilepsy显示文摘 | Vezzani A Balosso S Ravizza T | | 0，，6： | 1 |
| 5 | Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures显示文摘 | Maroso M Balosso S Ravizza T | 2010 | Nat Med2010，16，4： | 1 |
| 6 | Therapeutic effect and safety of adjunctive risperidone in refractoy obsessive-compulsive disorder(OCD)显示文摘 | Ravizza L Barzega G Bellino S | 1996 | Psychopharmacol Bull1996，32，： | 1 |
| 7 | The role of cytokines in the pathophysiology of epilepsy显示文摘 | Annamaria Vezzani Silvia Balosso Teresa Ravizza | 2008 | Brain Behavior and Immunity2008，，6： | 1 |
| 8 | The role of cytokines in the pathophysiology of epilepsy显示文摘 | Vezzani A Balosso S Ravizza T | 2008 | Brain Behav Immun2008，22，6： | 1 |
| 9 | The role of cytokines in the patho- physiology of epilepsy 显示文摘 | Vezzani A Balosso S Ravizza T | 2008 | Brain Behav Immun2008，22，6： | 1 |
| 10 | Molecular determinants of intrinsic resistance to doxorubicin in human cancer cell lines显示文摘 | Gariboldi M B Ravizza R Riganti L | 2003 | Int J Oncol2003，22，5： | 1 |
| 11 | Therecord of sea water ^187Os/^186Os variation through the Cenozoic 显示文摘 | Pegram W J Krishnaswami S Ravizza G E 等 | 1992 | Earth and Ptanetary Science Letters1992，113，： | 1 |
| 12 | Status epilepficus induces time-dependent neuronal and astrocytic expression of interleukin-1 receptor type 1 in the rat limbic system 显示文摘 | Vezzani A Ravizza T | 2006 | Neuroscience2006，137，1： | 1 |
| 13 | Innate and adaptive immunity during epileptogenesis and spontaneous seizures:evidence from experimental models and human temporal lobe epilepsy显示文摘 | Ravizza T Gagliardi B Noe F | 2008 | Neurobiol Dis2008，29，1： | 1 |
| 14 | Antiretroviral therapy at conception in pregnant women with HIV in Italy:wide range of variability and frequent exposure to contraindicated drugs 显示文摘 | Floridia M Tamburrini E Ravizza M | 2006 | J Antivir Ther2006，11，： | 1 |
| 15 | Status epilepticus induces time-dependent neuronal and astrocytic expression of interleukin-1 receptor type 1 in the rat limbic system显示文摘 | Ravizza T Yezzani A | 2006 | Neuroscience2006，137，1： | 1 |
| 16 | Tumor necrosis factor alpha inhibits seizures in mice via p75 receptors显示文摘 | Balosso S Ravizza T Perego C | 2005 | Ann Neurol2005，57，6： | 1 |
| 17 | The role of cyto kines in the pathophysiology of epilepsy 显示文摘 | Vezzani A Balosso S Ravizza T | 2008 | Brain Behav Immun2008，22，6： | 1 |
| 18 | Innate and adaptive immunity during epileptogenesis and spontaneous seizures:evidence from experimental models and human temporal lobe epilepsy显示文摘 | Ravizza T Gagliardi B Noe F | 2008 | Neurobiol Dis2008，29，1： | 1 |
| 19 | Innate and adaptive immunity during epileptogenesis and spontane- ous seizures:evidence from experimental models and human temporal lobe epilepsy 显示文摘 | Ravizza T Gagliardi B No6 F Boer K Aronica E Vezzani A | 2008 | Neurobiol Dis2008，29，1： | 1 |
| 20 | Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus显示文摘 | De Simoni MG Perego C Ravizza T | 2000 | Eur J Neurosci2000，12，7： | 1 |
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