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| 1 | Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer’s disease and dementia with Lewy bodies显示文摘Background:Because of the increasing life expectancy in our society,aging-related neurodegenerative disorders are one of the main issues in global health.Most of these diseases are characterized by the deposition of misfolded proteins and a progressive cognitive decline.Among these diseases,Alzheimer’s disease(AD)and dementia with Lewy bodies(DLB)are the most common types of degenerative dementia.Although both show specific features,an important neuropathological and clinical overlap between them hampers their correct diagnosis.In this work,we identified molecular biomarkers aiming to improve the misdiagnosis between both diseases.Methods:Plasma extracellular vesicles(EVs)-from DLB,AD and healthy controls-were isolated using size-exclusion chromatography(SEC)and characterized by flow cytometry,Nanoparticle Tracking Analysis(NTA)and cryo-electron microscopy.Next Generation Sequencing(NGS)and related bibliographic search was performed and a selected group of EV-associated microRNAs(miRNAs)was analysed by qPCR.Results:Results uncovered two miRNAs(hsa-miR-451a and hsa-miR-21-5p)significantly down-regulated in AD samples respect to DLB patients,and a set of four miRNAs(hsa-miR-23a-3p,hsa-miR-126-3p,hsa-let-7i-5p,and hsamiR-151a-3p)significantly decreased in AD respect to controls.The two miRNAs showing decreased expression in AD in comparison to DLB provided area under the curve(AUC)values of 0.9 in ROC curve analysis,thus suggesting their possible use as biomarkers to discriminate between both diseases.Target gene analysis of these miRNAs using prediction online tools showed accumulation of phosphorylation enzymes,presence of proteasome-related proteins and genes involved in cell death among others.Conclusion:Our data suggest that plasma-EV associated miRNAs may reflect a differential profile for a given dementia-related disorder which,once validated in larger cohorts of patients,could help to improve the differential diagnosis of DLB versus AD. | Ana Gámez-Valero Jaume Campdelacreu Dolores Vilas Lourdes Ispierto Ramón Reñé RamiroÁlvarez MPilar Armengol Francesc E.Borràs Katrin Beyer | 2019 | Translational Neurodegeneration2019，8，1： | 4 |
| 2 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 3 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 4 | 血管生成素样蛋白2水平与肾移植术后主动脉僵硬度和死亡率呈正相关显示文摘血管生成素样蛋白2(angiopoietin-like-2,ANGPTL2)是一种分泌性糖蛋白,可诱发血管内皮功能障碍、动脉粥样硬化和心血管病。循环ANGPTL2在慢性肾脏病(chronic kidney disease,CKD)患者中增加,加重患心血管病的风险。 | Desjardins MP Thorin-Trescases N Sidibé A Fortier C DeSerres SA Larivière R Thorin E Agharazii M 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 5 | Fatal anaphy laxis to indoornative fire ant stings in an infant显示文摘 | More D Kohlmeier RE Hoffma N | 2008 | Am J Forensic Med Pathol2008，29，1： | 1 |
| 6 | Noninvasive positive pressure ventilation via face mask firsfline intervention in patients with acute hypercapnic respiratory failure 显示文摘 | Meduri GU Turner RE Abou-shala N | 1996 | Chest1996，109，1： | 1 |
| 7 | Cooperative interactions of laminin 5 gamma2 chain, matrix metalloproteinase-2, and membrane type1-matrix metalloproteinase are required for mimicry of embryonic vasculogenesis by aggressive melanoma 显示文摘 | Seftor RE Seftor EA Koshikawa N | 2001 | Cancer Res2001，61，17： | 1 |
| 8 | Antioxidant ac- tivity applying an improved ABTS radical cation decolorization assay显示文摘 | RE R PELLEGRINI N PROTEGGENTE A | 1999 | Free Radical Biology and Medicine1999，26，910： | 1 |
| 9 | Antioxidant activity ap- plying an improved ABTS radical cation decolorization assay 显示文摘 | RE R PELI_EGRINI N PROTEGGENTE A | 1999 | FreeRadical Biology and Medicine1999，26，910： | 1 |
| 10 | 查看详情显示文摘 | Mijatovic T De Nève N Bruyère C Simon G Dewelle J Van Quaquebeke E Van Der A.E Van Vynckt F Lefranc F Kiss R | | 0，，： | 1 |
| 11 | Is nasogastric or na- sojejunal decompression necessary after gastrectomy? A prospective randomized trial显示文摘 | Carr~re N Seulin P Julio CH | 2007 | World J Surg2007，31，1： | 1 |
| 12 | Obstructive sleep apnea and heart disease: the biomarkers point of view显示文摘 | VITULANO N DI MARCO BERARDINO A RE A | 2013 | Front Biosci (Schol Ed)2013，5，： | 1 |
| 13 | Profiling posttransplant circulating antibodies in kidney transplantation using donor endothelial cells显示文摘 | Canet E Devallière J Gérard N | 2012 | Transplantation2012，93，3： | 1 |
| 14 | A Simple Approach to the Thermo ElastoHydroDynamic Behavior of Me-chanical Face Seals显示文摘 | Brunetière N Apostolescu A | 2009 | Tribology Transactions2009，52，2： | 1 |
| 15 | Antioxidant ac- tivity applying an improved ABTS radical cation decoloriza- tion assay 显示文摘 | Re R Pellegrini N Proteggente A | 1999 | Free Radical Biology & Medicine1999，26，910： | 1 |
| 16 | Antioxidant activity applying an improved ABTS radical cation decolorization assay 显示文摘 | Re R Pellegrini N Proteggente A | 1999 | Free Radical Biology&Medicine1999，26，910： | 1 |
| 17 | Optimized granulocyte colony-stimulating factor prophylaxis in adult cancer patients:from biological principles to clinical guidelines显示文摘 | Silvestris N Del Re M Azzariti A | | 0，，2： | 1 |
| 18 | Viable circulating tumour cell detection using multiplex RNA in situ hybridisation predicts progression-free survival in metastatic breast cancer patients 显示文摘 | Payne RE Wang F Su N | 2012 | Br J Cancer2012，106，11： | 1 |
| 19 | Enhanced benefit fi'om adjuvant chemotherapy in breast cancer patients classified high-risk accoding to urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor typel ( N = 3424) 显示文摘 | Harbeck N Kates RE Look MP Meijer-van Gelder ME Klijn JGM Kruger A | 2002 | Cancer Res2002，2，16： | 1 |
| 20 | Innovation strategies for radiation necrosis of the central nervous system显示文摘 | Nieder C Andratschke N Price RE | | Anticancer Res0，22，2： | 1 |
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