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| 1 | Longer duration of initial invasive mechanical ventilation is still a crucial risk factor for moderate‑to‑severe bronchopulmonary dysplasia in very preterm infants:a multicentrer prospective study显示文摘Objectives We aimed to evaluate the risk factors for moderate-to-severe bronchopulmonary dysplasia(BPD)and focus on discussing its relationship with the duration of initial invasive mechanical ventilation(IMV)in very preterm neonates less than 32 weeks of gestational age(GA).Methods We performed a prospective cohort study involving infants born at 23–31 weeks of GA who were admitted to 47 different neonatal intensive care unit(NICU)hospitals in China from January 2018 to December 2021.Patient data were obtained from the Sina-northern Neonatal Network(SNN)Database.Results We identified 6538 very preterm infants,of whom 49.5%(3236/6538)received initial IMV support,and 12.6%(823/6538)were diagnosed with moderate-to-severe BPD symptoms.The median duration of initial IMV in the moderateto-severe BPD group was 26(17–41)days,while in the no or mild BPD group,it was 6(3–10)days.The incidence rate of moderate-to-severe BPD and the median duration of initial IMV were quite different across different GAs.Multivariable logistic regression analysis showed that the onset of moderate-to-severe BPD was significantly associated with the duration of initial IMV[adjusted odds ratio(AOR):1.97;95%confidence interval(CI):1.10–2.67],late-onset neonatal sepsis(LONS),and patent ductus arteriosus(PDA).Conclusion In this multicenter cohort study,the duration of initial IMV was still relatively long in very premature infants,and the longer duration of initial IMV accounts for the increased risk of moderate-to-severe BPD. | Cong Dou Yong-Hui Yu Qing-Cui Zhuo Jian-Hong Qi Lei Huang Yan-Jie Ding De-Juan Yang Li Li Dan Li Xiao-Kang Wang Yan Wang Xin Qiao Xiang Zhang Bing-Jin Zhang Hai-Yan Jiang Zhong-Liang Li Simmy Reddy | 2023 | World Journal of Pediatrics2023，19，6： | 2 |
| 2 | Induced systemic pro-tection against tomato late blight elicited by plant growth-promoting rhizobacteria显示文摘 | Yan Z N Reddy M S Ryu C M | | 0，，12： | 1 |
| 3 | 查看详情显示文摘 | Hu C Y Reddy N Yan K Yang Y Q | | 0，，： | 1 |
| 4 | Induced systemic protection against tomato late blight elicited by plant-promoting rhizobacteria显示文摘 | Yan Zhi-nong Reddy M S Choong-Min Ryu | 2002 | Phytopathology2002，92，： | 1 |
| 5 | Induced systemic protection against tomato late blight elicited by plant growth-promoting rhizobacteria显示文摘 | Yan Z Reddy M S Ryu C M | 2002 | Phytopathology2002，92，12： | 1 |
| 6 | Microbiota Separation and C-reactive Protein Elevation in Treatment-na?ve Pediatric Granulomatous Crohn Disease显示文摘 | Richard Kellermayer Sabina A.V. Mir Dorottya Nagy-Szakal Stephen B. Cox Scot E. Dowd Jess L. Kaplan Yan Sun Sahna Reddy Jiri Bronsky Harland S. Winter | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，3： | 1 |
| 7 | Effect of moisture stress on stability of membrane integrity in Hevea brasiliensis across temperature regimes显示文摘 | Reddy Yan | 2000 | Ind J For2000，23，1： | 1 |
| 8 | Agrobacterium tumefa-ciens-mediated transformation of soybeanusing immature zygotic cotyledon explants显示文摘 | Yan B Reddy M S S Collins G B | 2000 | Plant CellRep2000，20，： | 1 |
| 9 | 查看详情显示文摘 | (d) Yan L Huo P Debenham J S Madsen-Duggan C B Lao J Chen R Z Xiao J C Shen C -P Stribling D S Shearman L P Strack A M Tsou N Ball R G Wang J Tong X Bateman T J Reddy V B G Fong T M Hale J J | | 0，，： | 1 |
| 10 | Agrobacterium tumefaciens-mediated transformation of soybeanusing immature zygotic cotyledon explants显示文摘 | Yan B Srinivasa Reddy M S Collins G B | 2000 | Plant Cell Reps2000，20，： | 1 |
| 11 | Thermoplastic films from cyanoethylated chicken feathers显示文摘 | REDDY N HU C Y YAN K L | 2011 | Materials Science and Engineering: C2011，31，8： | 1 |
| 12 | Synthesis and characterization of highly flexible thermoplastic films from cyanoethylated corn distillers dried grains with solubles显示文摘 | Hu C Y Reddy N Yan Kelu | 2011 | Journal of Agricultural and Food Chemistry2011，59，5： | 1 |
| 13 | Inhibition of Rgs10 Expression Prevents Immune Cell Infiltration in Bacteria-induced Inflammatory Lesions and Osteoclast-mediated Bone Destruction显示文摘Regulator of G-protein Signaling 10(Rgs10)plays an important function in osteoclast differentiation.However,the role of Rgs10 in immune cells and inflammatory responses,which activate osteoclasts in inflammatory lesions,such as bacteria-induced periodontal disease lesions,remains largely unknown.In this study,we used an adeno-associated virus(AAV-)mediated RNAi(AAV-shRNA-Rgs10)knockdown approach to study Rgs10’s function in immune cells and osteoclasts in bacteria-induced inflammatory lesions in a mouse model of periodontal disease.We found that AAV-shRNA-Rgs10 mediated Rgs10 knockdown impaired osteoclastogenesis and osteoclast-mediated bone resorption,in vitro and in vivo.Interestingly,local injection of AAV-shRNA-Rgs10 into the periodontal tissues in the bacteria-induced inflammatory lesion greatly decreased the number of dendritic cells,T-cells and osteoclasts,and protected the periodontal tissues from local inflammatory damage and bone destruction.Importantly,AAV-mediated Rgs10 knockdown also reduced local expression of osteoclast markers and pro-inflammatory cytokines.Our results demonstrate that AAVshRNA-Rgs10 knockdown in periodontal disease tissues can prevent bone resorption and inflammation simultaneously.Our data indicate that Rgs10 may regulate dendritic cell proliferation and maturation,as well as the subsequent stimulation of T-cell proliferation and maturation,and osteoclast differentiation and activation.Our study suggests that AAV-shRNA-Rgs10 can be useful as a therapeutic treatment of periodontal disease. | Sen Yang Liang Hao Matthew McConnell Xuedong Zhou Min Wang Yan Zhang John D Mountz Michael Reddy Paul D. Eleazer Yi-Ping Li Wei Chen | 2013 | Bone Research2013，1，3： | 0 |
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