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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Analysis and design for a class of complex control systems, Part Ⅱ: fuzzy controller design显示文摘 | CAO S G REES N W FENG G | 1997 | Automatica1997，33，： | 1 |
| 3 | A tran sient two-dimensional finite volume model for the simulation of vertical U-tube ground heat exchanges 显示文摘 | YAVUZTURK C SPLITLER J D REES S J | 1999 | ASHRAE Transactions1999，105，2： | 1 |
| 4 | Development of gfp yectors for expression in Listeria monocytogenes and other low G + C gram positive bacteria 显示文摘 | QAXI S N A REES C E D MELLITS K H | 2001 | Microbiology Ecology2001，41，4： | 1 |
| 5 | Further results about quadratic stability of continuous-time fuzzy control systems显示文摘 | Cao S G Rees N W Feng G | 1997 | System Science1997，28，4： | 1 |
| 6 | New route to 2-cyanobenzimidazoles 显示文摘 | Konstantinova L S Rakitin O A Rees C W | 1998 | Tetrahedron1998，54，： | 1 |
| 7 | MHD free and forced convection boundary layer flow along a vertical porous plate显示文摘 | Hossaln M A Alam K C A Rees D A S | 1997 | Appl Mech Engrg1997，2，1： | 1 |
| 8 | Preparation and Structural Characterization of, and Chemical Vapor Deposition Studies with Certain Yttrium Tris (fl-Diketonate) Compounds 显示文摘 | Luten H A Rees Jr W S Goedken V L | 1996 | Chem Vap Deposition1996，2，： | 1 |
| 9 | The Stability of Lactic Acid Production in Resting Suspensions of Lactobacillus Delbrueeckii显示文摘 | REES J F PIRT S J | 1979 | Journal of Chemical Technology and Biotechnology1979，29，9： | 1 |
| 10 | Scattering properties of a cut-circle billiard waveguide with two conical leads 显示文摘 | FUCHSS K REE S H REICHL L E | 2001 | Phys Rev E2001，63，01： | 1 |
| 11 | The effect of glucose on the control of carbohydrate m343 etabolism in ripening bananas显示文摘 | HILL S A AP REES T | 1995 | Planta1995，196，： | 1 |
| 12 | Temporal variability of denitrification in estuarine sediments显示文摘 | LAW C S REES A P OWENS N J P | 1991 | Estuarine Coastal and Shelf Science1991，33，1： | 1 |
| 13 | Size-fractionated nitrogen uptake and carbon fixation during a developing coccolithophore bloom in the North Sea during June 1999显示文摘 | Malcolm E Woodward S Robinson C Cummings D G Tarran G A Joint Ⅰ | 2002 | Deep-Sea Research Ⅱ2002，49，15： | 1 |
| 14 | Abaronov-bohm effect and resonances in the circular quantum billiard with two leads显示文摘 | REE S H REICHL L E | 1999 | Phys Rev B1999，59，： | 1 |
| 15 | The effect of hypoxia on the control of carbohydrate metabolism in ripening bananas显示文摘 | HILL S A AP REES T | 1995 | Planta1995，197，： | 1 |
| 16 | Formation of zeolite from the system Na2O-Al2O3-H2O in alkaline medium (pH>10) 显示文摘 | Lovat V C Ree s Sathy Chandrasekhar | 1993 | Zeolites1993，13，： | 1 |
| 17 | Prolonged reductions in placental blood flow and cerebral oxygen delivery in preterm fetal sheep exposed to endotoxin: Possible factors in white matter injury after acute infectioni 显示文摘 | Dalitz P Harding R Rees S | 2003 | J Soc Gynecol Invest2003，10，5： | 1 |
| 18 | The biological basis of injury and neuroprotection in the fetal and neonatal brain 显示文摘 | Rees S Harding R Walker D | 2011 | Int J Dev Neurosci2011，29，6： | 1 |
| 19 | Maternal protein intake in the pregnant rat programs the insulin axis and body composition in the offspring 显示文摘 | REES W D HAY S M CRUICKSHANK M | 2006 | Metabolism2006，55，5： | 1 |
| 20 | Nitrous oxide: Estuarine sources and atmospheric flux 显示文摘 | LAW C S REES A P OWENS N J P | 1992 | Estuarine Coastal and Shelf Science1992，35，3： | 1 |
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