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| 1 | High-fat-induced intestinal permeability dysfunction associated with altered fecal bile acids显示文摘AIM:To investigate whether high-fat-feeding is associated with increased intestinal permeability via alterations in bile acid metabolism.METHODS:Male C57Bl/6J mice were fed on a high-fat (n=26) or low-fat diet (n=24) for 15 wk.Intestinal permeability was measured from duodenum,jejunum,ileum and colon in an Ussing chamber system using 4 kDa FITC-labeled dextran as an indicator.Fecal bile acids were analyzed with gas chromatography.Segments of jejunum and colon were analyzed for the expression of farnesoid X receptor (FXR) and tumor necrosis factor (TNF).RESULTS:Intestinal permeability was significantly increased by high-fat feeding in jejunum (median 0.334 for control vs 0.393 for high-fat,P=0.03) and colon (0.335 for control vs 0.433 for high-fat,P=0.01),but not in duodenum or ileum.The concentration of nearly all identified bile acids was significantly increased by high-fat feeding (P<0.001).The proportion of ursodeoxycholic acid (UDCA) in all bile acids was decreased (1.4%±0.1% in high-fat vs 2.8%±0.3% in controls,P<0.01) and correlated inversely with intestinal permeability (r=-0.72,P=0.01).High-fat feeding also increased jejunal FXR expression,as well as TNF expression along the intestine,especially in the colon.CONCLUSION:High-fat-feeding increased intestinal permeability,perhaps by a mechanism related to bile acid metabolism,namely a decreased proportion of fecal UDCA and increased FXR expression. | Lotta K Stenman Reetta Holma Riitta Korpela | 2012 | World Journal of Gastroenterology2012，18，9： | 19 |
| 2 | Faecal microbiota transplantation in patients with Clostridium difficile and significant comorbidities as well as in patients with new indications:A case series显示文摘Fecal microbiota transplantation(FMT) is effective in recurrent Clostridium difficile infection(r CDI). Knowledge of the safety and efficacy of FMT treatment in immune deficient patients is scarce. FMT has been suggested as a potential method for an increasing number of new indications besides r CDI. Among our FMT-treated r CDI patients, we reviewed those with major comorbidities: two human immunodeficiency virus patients, six haemodialysis patients, two kidney transplant patients, two liver transplant patients and a patient with chronic lymphatic leukaemia. We also reviewed those treated with FMT for indications other than r CDI: Salmonella carriage(two patients), trimethylaminuria(two patients), small intestinal bacterial overgrowth(SIBO;one patient), and lymphocytic colitis(one patient), as well as a common variable immunodeficiency patient with chronic norovirus infection and ESBL-producing Escherichia coli(E. coli) carriage. Of the thirteen r CDI patients treated with FMT, eleven cleared the CDI. The observed adverse events were not directly attributable to FMT. Concerning the special indications, both Salmonellas and ESBL-producing E. coli were eradicated. One trimethylaminuria patient and one SIBO-patient reported a reduction of symptoms. Three patients did not experience a benefit from FMT: chronic norovirus, lymphocytic colitis and the other fish malodour syndrome. There were no reported side effects in this group. FMT appeared to be safe and effective for immunocompromised patients with r CDI. FMT showed promise for the eradication of antibiotic-resistant bacteria, but further research is warranted. | Perttu Lahtinen Eero Mattila Veli-Jukka Anttila Jyrki Tillonen Matti Teittinen Pasi Nevalainen Seppo Salminen Reetta Satokari Perttu Arkkila | 2017 | World Journal of Gastroenterology2017，23，39： | 2 |
| 3 | Effects of the viability of Lactobacillus rhamnosus GG on rotavirus infection in neonatal rats显示文摘AIM:To study the effects of live and dead Lactobacillus rhamnosus GG(GG) on rotavirus infection in a neonatal rat model.METHODS:At the age of 2 d,suckling Lewis rat pups were supplemented with either live or dead GG and the treatment was continued daily throughout the experi-ment.At the age of 5 and 6 d the pups received oral rotavirus(RV) SA-11 strain.The pups were sacrificed at the age of 7 or 8 d by decapitation.The gastrointestinal tract was removed and macroscopic observations were done.The consistency of feces in the colon was classified using a four-tier system.RV was detected from the plasma,small intestine,colon and feces by real-time quantitative polymerase chain reaction(PCR).RESULTS:In this neonatal rat model,RV induced a mild-to-moderate diarrhea in all except one pup of the RV-inoculated rats.RV moderately reduced body weight development from day 6 onwards.On day 7,after 2 d of RV infection,live and dead GG groups gained significantly more weight than the RV group without probiotics [36%(P = 0.001) and 28%(P = 0.031),respectively].In addition,when compared with the RV control group,both live and dead GG reduced the weight ratio of colon/animal body weight to the same level as in the healthy control group,with reductions of 22%(P = 0.002) and 28%(P < 0.001),respectively.Diarrhea increased moderately in both GG groups.However,the diarrhea incidence and severity in the GG groups were not statistically significantly different as compared with the RV control group.Moreover,observed diarrhea did not provoke weight loss or death.The RV control group had the largest amount of RV PCR-positive samples among the RV-infected groups,and the live GG group had the smallest amount.Rats receiving live GG had significantly less RV in the colon(P = 0.027) when compared with the RV control group.Live GG was also more effective over dead GG in reducing the quantity of RV from plasma(P = 0.047).CONCLUSION:Both live and dead GG have beneficial effects in RV infection.GG may increase RV clearance from the body and reduce colon swelling. | Hanna Ventola Liisa Lehtoranta Mari Madetoja Marja-Leena Simonen-Tikka Leena Maunula Merja Roivainen Riitta Korpela Reetta Holma | 2012 | World Journal of Gastroenterology2012，18，41： | 2 |
| 4 | Double-blind study of gabapentin in the treatment of partial aeizures 显示文摘 | Juhani Sivenius Reetta K Aarne Ylinen | 1991 | Epilepsia1991，32，4： | 1 |
| 5 | Carotid stenosis degree in CT angiography: assessment based on luminal area versus luminal diameter measurements显示文摘 | Zishu Zhang Marja Berg Aki Ikonen Mervi K?n?nen Reetta K?lvi?inen Hannu Manninen Ritva Vanninen | | 0，，： | 1 |
| 6 | Heparin-binding protein:a potential biomarker in sepsi显示文摘 | Reetta Huttunen Jaana Syrjnen | 2010 | Clin Infectious Diseases2010，50，2： | 1 |
| 7 | New conceptsin the pathogenesis, diagnosis and treatment otbaceteremiaandSepsis 显示文摘 | Reetta H Janne A | 2011 | Journal of Infection2011，63，6： | 1 |
| 8 | Optimizing treatment of epilepsy during pregnancy 显示文摘 | Reetta Kalviainen Torbjom Tomson | 2006 | Neurology2006，67，4： | 1 |
| 9 | Blood cyto- kines during the perinatal period in very preterm infants: relationship of inflammatory response and brenchopulmonary dysplasia 显示文摘 | Reija Paananen Anna-Karin Husa Reetta Vuolteenaho | 2009 | The Journal of Pediatrics2009，154，1： | 1 |
| 10 | Remodeling of neuronal circuitries in human temporal lobe epilepsy:increased expression of highly polysialylated neural cell adhesion molecule in the hippocampus and the entorhinal cortex显示文摘 | Mikkonen M Hilkka S Reetta K | 1998 | Ann Neurol1998，44，： | 1 |
| 11 | New concepts in the pathogenesis,diagnosis and treatment of bacteremia and sepsis显示文摘 | Reetta H Janne A | 2011 | J Inf2011，63，6： | 1 |
| 12 | Constipation Is Relieved More by Rye Bread Than Wheat Bread or Laxatives without Increased Adverse Gastrointestinal Effects1,2显示文摘 | Holma Reetta Hongisto Sanna-Maria Saxelin Maija Korpela Riitta | 2010 | The Journal of Nutrition2010，，3： | 1 |
| 13 | A bi-polar signal recorded in the western tropical Pacific: Northern and Southern Hemisphere climate records from the Pacific warm pool during the last Ice Age 显示文摘 | Reetta S Stolt L Thunell R | 2009 | Quaternary Science Reviews2009，28，： | 1 |
| 14 | Propofol in the treatment of refractory status epilepticus显示文摘 | Ilkka Parviainen Ari Uusaro Reetta K?lvi?inen Esa Mervaala Esko Ruokonen | 2006 | Intensive Care Medicine2006，，7： | 1 |
| 15 | Remodeling of neuronal eircuitries in human temporal lobe epilepsy increased expression ofhighly polysialylated neural cell adhesion molecule in the hippocampus and the entorhinal cortex显示文摘 | Mikkonen M Hilkka S Reetta K | 1998 | Ann Neurol1998，44，： | 1 |
| 16 | Optimizing treatment of epilepsy during pregnancy显示文摘 | Reetta Kalviainen Yorbjorn Yomson | 2006 | Neurology2006，67，： | 1 |
| 17 | Mucosal Adhesion Properties of the Probiotic Lactobacillus rhamnosus GG SpaCBA and SpaFEDPilin Subunits 显示文摘 | Ingemar O Justus R Reetta S | 2010 | Applied and Environmental Microbiology2010，76，7： | 1 |
| 18 | Blood Cytokines during the Perinatal Period in Very Preterm Infants: Relationship of Inflammatory Response and Bronchopulmonary Dysplasia显示文摘 | Reija Paananen Anna-Karin Husa Reetta Vuolteenaho Riitta Herva Tuula Kaukola Mikko Hallman | 2009 | The Journal of Pediatrics2009，，1： | 1 |
| 19 | Long-term effects of tiagabine monotherapy on cognition and mood in adult patients with chronic partial epilepsy显示文摘 | Marja ?iki? Leena Jutila Tuuli Salmenper? Esa Mervaala Reetta K?lvi?inen | 2006 | Epilepsy and Behavior2006，，4： | 1 |
| 20 | Remodeling of neu ronal circuitries in human temporal lobe epilepsy: increased expression of highly polysialylated neural cell adhesion molecule in the hippoeampus and the entorhinal cortex显示文摘 | Mikkonen M HilkkaS Reetta K | 1998 | Ann Neurol1998，44，6： | 1 |
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