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| 1 | 早期矽肺患者支气管肺泡灌洗液中生物标志物的研究显示文摘目的 探讨早期矽肺患者支气管肺泡灌洗液 (BALF)中生物标志物。方法 矽尘作业工人 18人 ,按X线诊断矽肺期别分为 0 +组和Ⅰ期组 ;以健康吸烟农民 7人为对照组。经纤支镜支气管肺泡灌洗收集BALF ,进行细胞学检验 ,用细胞毒性试验测定肿瘤坏死因子 (TNF α)含量 ,酶联免疫吸附法测定其他细胞因子含量。结果 矽肺 0 +组及Ⅰ期组BALF中TNF α含量分别为 (7.2 0±1.87)、(9.2 0± 1.10 )U/ml,明显高于对照组的 (5 .71± 0 .89)U/ml,差异有显著性 (P <0 .0 1) ;矽肺Ⅰ期组TNF α含量明显高于 0 +组 ,差异有显著性 (P <0 .0 5 )。TNF α含量与矽尘接触年限存在剂量 -效应关系 (rs=0 .46 98,P <0 .0 5 )。纤维连接蛋白、肺表面活性蛋白A和前胶原Ⅲ肽与对照比较 ,差异无显著性 (P >0 .0 5 )。结论 BALF中TNF | 冯国贤 南培宏 于建军 陈力 范连生 邢景才 周福同 宋鸿鹏 傅娟玲 Rehn B Rehn S Bruch J 周宗灿 | 2000 | 中华劳动卫生职业病杂志2000，18，4： | 11 |
| 2 | Changes of Tumor Necrosis Factor, Surfactant Protein A, and Phospholipids in Bronchoalveolar Lavage Fluid in the Development and Progression of Coal Workers’ Pneumoconiosis显示文摘Objective To evaluate the alterations of biomarkers in the development and progression of coal workers’ pneumoconiosis (CWP). Methods The type and number of cells, and the levels of tumor necrosis factor-alpha (TNF-α), pulmonary surfactant protein, phospholipids and fibronectin in bronchoalveolar lavage fluid were assayed in 14 health active coal miners, 21 coal miners without CWP and 13 miners with CWP of 0/1 to 1/1. Results Compared to active coal miners without CWP (8.23 μg/mL), TNF-α concentration was gradually decreased when dust exposure was stopped (5.90 μg/mL). Elevated surfactant protein A (SP-A) level and phosphatidylglycerol (PG) to phosphatidylinositol (PI) ratio were found in miners actively exposed to coal dust (6528 ng/mL for SP-A and 10. for PG/PI), and both parameters decreased when CWP progressed from CWP (0/1) (3419 μg/mL for SP-A and 5.9 for PG/PI) to CWP (1/1) (1654 μg/mL for SP-A and 5.5 for PG/PI). Conclusion Biomarkers in bronchoalveolar lavage fluid can be used to screen coal miners at high risk of developing coal workers’ pneumoconiosis. | JING-CAI XING WEI-HONG CHEN WEN-HUI HAN MEI-FENG GUO STEFFENI REHN JOACHIM BRUCH | 2006 | Biomedical and Environmental Sciences2006，19，2： | 7 |
| 3 | Interaction of endostain with integrins implicated in angiogenesis显示文摘 | Rehn M Veikkda T Kukk-Valadre E | 2001 | Proc Natl Acad Sci USA2001，98，3： | 2 |
| 4 | Tumor progression is associated with a significant decrease in the expression of the endostatin precursor collagen ⅩⅧ in human hepatocellular carcinomas 显示文摘 | Musso O Rehn M Theret N | 2001 | Cancer Res2001，61，1： | 1 |
| 5 | Advantages of Sirius red staining for quantitative morphometric collagen measurements in lungs 显示文摘 | Malkusch W Rehn B Bruch J | 1995 | Exp Lung Res1995，21，1： | 1 |
| 6 | The promoter of the long variant of collagen XVIII,the precursor of endostatin,contains liver-specific regulatory elements显示文摘 | LIETARD J THERET N REHN M | 2000 | Hepatology2000，32，6： | 1 |
| 7 | Live-born trisomy 22 :patient report and review显示文摘 | Heinrich T Nanda I Rehn M | 2013 | Mol Syndromol2013，3，6： | 1 |
| 8 | Characterization of the mouse gene for the alpha I chain of type XVⅢ collagen(Col 18a1)reveals that the three variant N-terminal polypeptide forms are transcribed from two widely separated Promoters显示文摘 | Rehn M Hintikka E Pihlajaniemi T | 1996 | Genomics1996，32，3： | 1 |
| 9 | 显示文摘 | Meng W J Tittsworth R C Rehn L E | 2000 | Thin Solid2000，，： | 1 |
| 10 | Diagnostic and Preoperative Staging of Endometrial Carcinoma with Transvaginal Sonography-A Review显示文摘 | Dietz NK Rehn M Thanner F | | 0，，： | 1 |
| 11 | Dielectric barrier discharge treatments at atmospheric pressure for wood surface modification 显示文摘 | P Rehn W Vipl | 2003 | Holz als Roh-und Werkstoff2003，61，2： | 1 |
| 12 | Complete primary structure of two variant forms of human type XVIII collagen and tissue-specific diffences in the expression of the corresponding transcript显示文摘 | Saarela J Ylik:irpp:i R Rehn M | 1998 | Matrix Biol1998，16，6： | 1 |
| 13 | Interaction of endostatin with integrins implicated in angiogenesis显示文摘 | Veikkola T Kukk-Valdre E | 2001 | Proc Natl Acad Sci2001，98，3： | 1 |
| 14 | Studies in the Orthopterus subfamilies Acrydiinae (Tettiginae), Eumastacinae and Proscopinae显示文摘 | Rehn J A G | 1904 | Proceedings of the Academy of Natural Scineces of Philadelphia1904，56，： | 1 |
| 15 | Investigation of the efficacy of oxenrutins compared to placebo in patients with chronic venous insufficiency treated with compression stockings显示文摘 | Unkauf M Rehn D klinger J | 1996 | Arzneimittelf orschung1996，46，3： | 1 |
| 16 | Effect of potassium and magnesium applied for corn grown on an irrigated sandy soll 显示文摘 | Rehn G W | 1985 | Soil Science Society of American Journal1985，49，6： | 1 |
| 17 | All-terrain vehicle use in agriculture: Exposure to whole body vibration and mechanical shock 显示文摘 | MILOSAVLJEVIC S BERGMAN F REHN B | 2010 | Applied Ergo- nomies2010，41，4： | 1 |
| 18 | Investigation of the therapeutic equivalence of different galenical preparations of O-(beta-hydroxyethyl)-rutosides following multiple dose peroral administration显示文摘 | Rehn D Brunnauer H Diebschlag W | 1996 | Arzneimittelforschung1996，46，3： | 1 |
| 19 | Characterization of GPRA a novel G protein-coupled receptor related to asthma显示文摘 | Vendelin J Pulkkinen V Rehn M | 2005 | Am J Respir Cell Mol Biol2005，33，： | 1 |
| 20 | Mechanical proper- ties and microstructure of TiC/amorphous hydrocarbon nanocomposite coatings 显示文摘 | Meng W J Tittsworth R C Rehn L E | 2000 | Thin Solid Films2000，，： | 1 |
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