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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Lactobacillus inhibitor production against Escherichia coli and coaggregation ability with uropathogens显示文摘 | REID G MCGROARTY J A ANGOTTI R | 1988 | Canadian Journal of Microbiology1988，34，3： | 1 |
| 3 | Renin:at the heart of the mast cell 显示文摘 | Reid A C Silver R B Levi R | 2007 | Immunological Review2007，217，： | 1 |
| 4 | Prognostic value of an RNA expression signature derived from ee cycle proliferation genes in patients with prostate cancer: a retrospective study显示文摘 | Cuzick J Swanson G P Fisher G Brothman A R Berney D M Reid J E | 2011 | Lancet Oncol2011，12，： | 1 |
| 5 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 6 | Pitavastatin显示文摘 | Mukhtar R Y A Reid J P Reckless J P D | 2005 | Int J Clin Pract2005，59，2： | 1 |
| 7 | A critical analysis of the causes of boron toxicity in plants显示文摘 | REID R J HAYES J E POST A | 2004 | Plant Cell Envi- ron2004，27，11： | 1 |
| 8 | In vivo induction of massive proliferation,directed migration,and differentiation of neural cells in the adult mammalian brain显示文摘 | Fallon J Reid S Kinyamu R Opole I Opole R Baratta J Korc M Endo TL Duong A Nguyen G Karkehabadhi M Twardzik D Patel S Loughlin S | | 0，，： | 1 |
| 9 | Large deformations of thin-walled circular tubes under transverse loading:Ⅱ:Experimental study of the crushing of circular tubes by centrally applied opposed wedge-shaped indenters显示文摘 | WATSON A R REID S R JOHNSON W | 1976 | International Journal of Mechanical Sciences1976，18，78： | 1 |
| 10 | Pattern recognition:recentinsights from Dectin-1显示文摘 | REID D M GOW N A R BROWN G D | 2009 | Current Opinion in Immunology2009，21，1： | 1 |
| 11 | Osteoporosis in menopause 显示文摘 | Khan A Fortier M Reid R | 2014 | Obstet Gynaecol Can2014，36，9： | 1 |
| 12 | Characterization of the 1918 influenza virus polymerase genes显示文摘 | Taubenbergerl J K Reid A H Lourens R M | 2005 | Nature2005，，437： | 1 |
| 13 | Human papillomavirus infection of the cervix:relative risk associations of 15 common anogenital types显示文摘 | Lorincz A T Reid R Jenson A B | 1992 | Obstet Gynecol1992，79，： | 1 |
| 14 | Clinical trial of community nurse mentoring to improve self - management in pa- tients with chronic obstructive pulmonary disease 显示文摘 | WOOD BAKER R REID D ROBINSON A | 2012 | Int J Chron Obstruct Pulmon Dis2012，7，： | 1 |
| 15 | Technical risk and new product success:an empirical test in high technology business markets显示文摘 | POLK R PLANK R E REID D A | 1996 | Industrial Marketing Management1996，25，6： | 1 |
| 16 | Deflection of RC Beams Under Simultaneous Load and Steel Corrosion显示文摘 | Ballim Y Reid J C Kemp A R | 2001 | Magazine of Concrete Research2001，53，3： | 1 |
| 17 | 1918 influenza pandemic caused by highly conserved viruses with two receptor-binding variants显示文摘 | Reid A H Janczewski T A Lourens R M | 2003 | Emerg Infect Dis2003，9，： | 1 |
| 18 | The limits of sodium/calcium in- teractions in plant growth显示文摘 | Reid R J Smith F A | 2000 | Australian Journal o{ Plant Physiology2000，27，7： | 1 |
| 19 | Recovery from propofol anesthesia supplemented with remifentanil 显示文摘 | Hare R A Mirakhui R K Reid J E | 2001 | Br J Anaesth2001，86，： | 1 |
| 20 | Dopamine for 'wanting' and opioids for 'liking' : a comparison of obese adults with and without binge eating 显示文摘 | DAVIS C A LEVITAN R D REID C | 2009 | Obesity2009，17，6： | 1 |
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