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| 1 | 儿童扩张型心肌病的发病率、病因及预后显示文摘背景:扩张型心肌病(dilated cardiomyopathy,DCM)是儿童心肌病最常见的类型,也是小儿心脏移植最常见的原因。但是,目前尚不清楚儿童DCM的流行病学特点和临床过程。
目的:详细描述儿童DCM的发病率、病因、预后及相关危险因素。
设计及地点:本项以人群为基础的前瞻性纵向队列研究入选1996年1月至2003年2月在89个儿科心脏中心诊断为DCM的儿童以及1990年1月至1995年12月在北美大型三级治疗中心诊断的患儿。
参试者:共入选1426例来自美国和加拿大的18岁以下DCM患儿。通过严格的超声心动图和/或病理学标准来诊断原发性DCM。因内分泌、免疫、药物中毒及其他原因患病者除外。
主要观测指标:每年每10万儿童的发病率、死亡率和心脏移植率。
结果:18岁以下儿童DCM每年的总发病率为0.57/10万,男孩的年发病率高于女孩(分别为0.66/10万和0.47/10万;P〈0.001),黑人的年发病率高于白人(分别为0.98/10万和0.46/10万;P〈0.001),婴儿(〈1岁)的年发病率高于儿童(分别为4.40/10万和0.34/10万;P〈0.001)。绝大部分属特发性,最常见的病因为心肌炎(46%)和神经肌肉性疾病(26%)。1年和5年死亡/移植率分别为31%和46%。死亡/移植的独立危险因素包括患儿诊断DCM时年龄较大、伴有充血性心力衰竭、左室收缩期Z评分较低以及DCM的病因(P均〈0.001)。
结论:儿童DCM有其多样性。患儿预后主要取决于病因、年龄和心力衰竭状况。人种、性别和年龄对发病率有一定影响。大部分患儿无明确病因,限制了特异性治疗。 | Jeffrey A. Towbin April M. Lowe Steven D. Colan Lynn A. Sleeper E. John Orav Sarah Clunie Jane Messere Gerald F. Cox Paul R. Lurie Daphne Hsu Charles Canter James D. Wilkinson Steven E. Lipshultz 康俊萍(译) 马长生(校) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 3 |
| 2 | Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications显示文摘 | Towbin H Staehelin T Gordon J | 1979 | Proc Natl Acad Sci USA1979，76，9： | 1 |
| 3 | Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets:procedure and some applications显示文摘 | Towbin H Staehelin T Gordon J | 1979 | Proc Natl Acad Sci U S A1979，76，9： | 1 |
| 4 | Clinic based study of plexiform neurofibromas in neurofibromatosis 1显示文摘 | Waggoner DJ Towbin J Gottesman G | 2000 | Am J Med Genet2000，92，2： | 1 |
| 5 | Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: proce- dure and some application显示文摘 | TOWBIN H STAEHELIN T GORDON J | 1979 | Proceedings of the National Academy of Sciences of the USA1979，76，： | 1 |
| 6 | Contemporary definitions and classification of the cardiomyopathies:an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee;Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups;and Council on Epidemiology and Prevention显示文摘 | Maron BJ Towbin JA Thiene G | 2006 | Circulation2006，113，14： | 1 |
| 7 | Contemporary definition and classification of the cardimyopathies 显示文摘 | Maron B Towbin JA Thiene G | 2006 | Circulation2006，113，14： | 1 |
| 8 | 儿童中扩张型心肌病的发生率、病因和预后 | Towbin J.A. Lowe A.M. Colan S.D. 马超 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，0，4： | 1 |
| 9 | Incidence, canses, and outcomes of dilated cardiomyopathy in children 显示文摘 | Towbin JA Lowe AM Colan SD | 2006 | J Am Med Assoc2006，296，15： | 1 |
| 10 | The 'final common pathway' hypothesis and inherited cardiovascular disease:the role of cytoskeletal proteins in dilated cardiomyopathy显示文摘 | Bowles NE Bowles KR Towbin JA | 2002 | Herz2002，25，： | 1 |
| 11 | Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention 显示文摘 | Maron BJ Towbin JA Thiene G | 2006 | Circulation2006，113，14： | 1 |
| 12 | Acute testicular ischemia caused by incarcerated inguinal hernia显示文摘 | Orth RC Towbin AJ | 2012 | Pediatr Radiol2012，42，2： | 1 |
| 13 | Contemporary definitions and : An American heart association scientific statement from the council on clinical cardiology,heart failure and transplantation committee ; Quality of care and outcomes research and functional genomics and translational biology interdisciplinary working groups;and council on epidemiology and prevention 显示文摘 | Maron B J Towbin JA Thiene G et classification of the cardiomyopathies al | 2006 | Circulation2006，113，14： | 1 |
| 14 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 15 | Guidelines for patient ra- diation dose management 显示文摘 | Stecker MS Baiter S Towbin RB et at | 2009 | J Vase Interv Radiol2009，20，： | 1 |
| 16 | Dilated cardiomyopathy 显示文摘 | Jefferics JL Towbin JA | 2010 | Lancet2010，375，9716： | 1 |
| 17 | Fatal Epstein - Barr Virus Myocarditis in a Child with Repetitive Myocarditis 显示文摘 | Hebert MM Yu C Towbin JA | 1995 | Pediatr Lab Med1995，15，： | 1 |
| 18 | Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity显示文摘 | Atkinson D Towbin JA | 1994 | Nat Genet1994，8，2： | 1 |
| 19 | Molecular determinants of left and right outflow tract obstruction 显示文摘 | TOWBIN J A BELMONT J | 2000 | Am J Med Genet2000，97，4： | 1 |
| 20 | Arginine vasopressin levels are elevated and correlate with functional status in infants and children with congestive heart failure显示文摘 | Price JF Towbin JA Denfield U | 2004 | Circulation2004，109，： | 1 |
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