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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Genetic markers, humoral autoimmunity, and predliction of type 1 diabetes in siblings of affected chidren显示文摘 | Kulmala P Savola K Reijonen H | 2000 | Diabetes2000，49，1： | 1 |
| 3 | Histology of injected autologous fascia in the paralyzed canine vocal fold显示文摘 | REIJONEN P LEIVO L NEVALAINEN T | 2001 | Laryngoscope2001，111，： | 1 |
| 4 | Genetic markers, humoral autoimmunity, and prediction of type 1 diabetes in siblings of affected显示文摘 | Kulmala P Savola K Reijonen H | 2000 | Diabetes2000，49，： | 1 |
| 5 | Histology of injection autologous fascia in the paralyzed vocal fold显示文摘 | Reijonen P Leivo L Nevalainen T | 2001 | Laryngoscope2001，111，： | 1 |
| 6 | Results of fascial augmentation in unilateral vocal fold paralysis显示文摘 | Reijonen P Lehikoinen-Soderlund S Rihkanen H | 2002 | Ann Otol Rhinol Laryngol2002，111，6： | 1 |
| 7 | Histology of injection autologous fascia in the paralyzed vocal fold显示文摘 | Reijonen P Leivo L Nevalainen T | 2001 | Laryngoscope2001，111，： | 1 |
| 8 | Results of fascial augmentation in unilateral vocal fold paralysis显示文摘 | Reijonen P Soderlund SL Rihkanen H | 2002 | Ann Otol Rhinol Laryngol2002，111，： | 1 |
| 9 | Genetic markers, humoral autoimmunity, and prediction of type 1 diabetes in siblings of affected children 显示文摘 | Kulmala P Savola K Reijonen H | 2000 | Diabetes2000，49，1： | 1 |
| 10 | Assessment of unilateral vocal fold paralysis after augmentation with autologous fascia显示文摘 | Rihkanen K Reijonen P Lehikkoinen-Soderlund S | 2004 | Eur Arch Otorhinolaryngol2004，261，： | 1 |
| 11 | Results of fascial augmentation in unilateral vocal fold paralysis显示文摘 | Reijonen P Lehikoinen-Soderlund S Rihkanen H | 2002 | Ann Otol Rhinol Laryngol2002，111，6： | 1 |
| 12 | Histology of injected autologous fascia in the paralyzed canine vocal fold显示文摘 | Reijonen P Leivo I Nevalainen T | 2001 | Laryngoscope2001，111，6： | 1 |
| 13 | Videostroboscopic assessment of unilateral vocal fold paralysis after augmentation with autologous fascia显示文摘 | Rihkanen H Reijonen P Lehikoinen-S oderlund S | 2004 | Eur Arch Otorhinolaryngo12004，261，： | 1 |
| 14 | Genetic markers, humoral autoimmunity , and prediction of type 1 diabetes in siblings of affected children显示文摘 | Kulmala P Savola K Reijonen H | 2000 | Diabetes2000，49，： | 1 |
| 15 | Histology of injected autologous fascia in the paralyzed canine vocal fold显示文摘 | Reijonen P Leivo I Nevalainen T | 2001 | Laryngoscope2001，111，： | 1 |
| 16 | Histology of injected autologous fascia in the paralyzed canine vocal fold 显示文摘 | Reijonen P Leivo I Nevalainen T | 2001 | Iaryngoseope2001，111，6： | 1 |
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