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9篇 您的检索式：作者名="Reimann Peter"

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		题名	作者	年代	出处	被引量
	1	Increased liver stiffness in alcoholic liver disease:Differentiating fibrosis from steatohepatitis显示文摘AIM:To test if inflammation also interferes with liver stiffness (LS) assessment in alcoholic liver disease (ALD) and to provide a clinical algorithm for reliable fibrosis assessment in ALD by FibroScan (FS).METHODS:We first performed sequential LS analysis before and after normalization of serum transaminases in a learning cohort of 50 patients with ALD admitted for alcohol detoxification. LS decreased in almost all patients within a mean observation interval of 5.3 d. Six patients (12%) would have been misdiagnosed with F3and F4 fibrosis but LS decreased below critical cut-off values of 8 and 12.5 kPa after normalization of trans-aminases. RESULTS:Of the serum transaminases,the decrease in LS correlated best with the decrease in glutamic oxaloacetic transaminase (GOT). No significant chang-es in LS were observed below GOT levels of 100 U/L. After establishing the association between LS and GOT levels,we applied the rule of GOT < 100 U/L for reliable LS assessment in a second validation cohort of 101 patients with histologically confi rmed ALD. By ex-cluding those patients with GOT > 100 U/L at the time of LS assessment from this cohort,the area under the receiver operating characteristic (AUROC) for cirrhosis detection by FS improved from 0.921 to 0.945 while specificity increased from 80% to 90% at a sensitivity of 96%. A similar AUROC could be obtained for lower F3 fibrosis stage if LS measurements were restricted to patients with GOT < 50 U/L. Histological grading of inflammation did not further improve the diagnostic accuracy of LS.CONCLUSION:Coexisting steatohepatitis markedly increases LS in patients with ALD independent of fibrosis stage. Postponing cirrhosis assessment by FS during alcohol withdrawal until GOT decreases to < 100 U/mL signif icantly improves the diagnostic accuracy.	Sebastian Mueller Gunda Millonig Lucie Sarovska Stefanie Friedrich Frank M Reimann Maria Pritsch Silke Eisele Felix Stickel Thomas Longerich Peter Schirmacher Helmut Karl Seitz	2010	World Journal of Gastroenterology2010，16，8：	10
	2	The role of V2 vasopressin antagonists in hyponatremia 显示文摘	Catrin Palm Doreen Reimann Peter Gross	2001	Cardiovasc Res2001，51，：	1
	3	Viral burden and disease progression in rhesus monkeys infected with chimeric simian-human immunodeficiency viruses显示文摘	Reimann KA Watson A Peter J	1999	Virology1999，256，：	1
	4	Loop reactors:better gas/liquid contact 显示文摘	Gunter M Leuteritz Peter Reimann Pierre Vergeres	1976	Hydrocarbon Processing1976，55，：	1
	5	Quantifying stochastic resonance: theory versus experiment显示文摘	Evstigneev Mykhaylo Reimann Peter Schmitt Car- men	2005	Journal of Physics: Condensed Matter2005，17，：	1
	6	Multivariate outlier detection in exploration geochemistry 显示文摘	Filzmoser Peter Garret Robert G Reimann Clemens	2005	Computers&Geosciences2005，31，：	1
	7	Viral Burden and Disease Progrossion in Rhesus Monkeys Infected with Chimeric Simian - Human Immunedeficiency Viruses 显示文摘	Reimann KA Watson A Peter J	1999	Virology 2561999，1521，：	1
	8	Multimedia Learning: Beyond Modality 显示文摘	Reimann Peter	2003	Learning and Instruction2003，，2：	1
	9	Viral burden and disease progression in rhesus monkeys infected with chimeric simian-human immunodeficiency viruses显示文摘	Reimann KA Watson A Peter J	1999	Virology1999，256，1：	1

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