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| 1 | Microbial markers in colorectal cancer detection and/or prognosis显示文摘Colorectal cancer(CRC) is the second leading cause of cancer worldwide. CRC is still associated with a poor prognosis among patients with advanced disease. On the contrary, due to its slow progression from detectable precancerous lesions, the prognosis for patients with early stages of CRC is encouraging. While most robust methods are invasive and costly, actual patient-friendly screening methods for CRC suffer of lack of sensitivity and specificity. Therefore, the development of sensitive, non-invasive and cost-effective methods for CRC detection and prognosis are necessary for increasing the chances of a cure. Beyond its beneficial functions for the host, increasing evidence suggests that the intestinal microbiota is a key factor associated with carcinogenesis. Many clinical studies have reported a disruption in the gut microbiota balance and an alteration in the faecal metabolome of CRC patients, suggesting the potential use of a microbialbased test as a non-invasive diagnostic and/or prognostic tool for CRC screening. This review aims to discuss the microbial signatures associated with CRC known to date, including dysbiosis and faecal metabolome alterations, andthe potential use of microbial variation markers for noninvasive early diagnosis and/or prognostic assessment of CRC and advanced adenomas. We will finally discuss the possible use of these markers as predicators for treatment response and their limitations. | Romain Villéger Amélie Lopès Julie Veziant Johan Gagnière Nicolas Barnich Elisabeth Billard Delphine Boucher Mathilde Bonnet | 2018 | World Journal of Gastroenterology2018，24，22： | 10 |
| 2 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 3 | Distribution of immature and monitoring of adult sweet potato whitefly, Bemisia tabaci ,in peanut, Arachis hypogeaea 显示文摘 | Lynch RE Simmons AM | 1993 | Environmental Entomology1993，，22： | 1 |
| 4 | Aortic root replacement:Risk factor analysis of a seventeen year experience with 270 patients显示文摘 | Gott VL Gillinov Am Pyeritz RE | 1995 | J Thorac Cardiovsc Surg1995，109，3： | 1 |
| 5 | Effect of maternal and treatment related factors on the prevalence of birth defects af ter PESA-ICSI and TESE ICSI: a retrospective cohort study显示文摘 | Meijerink AM ()omen RE Fleischer K et M | 2015 | Acta Obstet Gynecol Scand2015，123，12： | 1 |
| 6 | Calpeptin provides functional neuroprotection to rat retinal ganglion cells following Ca2+ influx显示文摘 | Das A Gamer DP del Re AM | 2006 | Brain Res2006，1084，1： | 1 |
| 7 | Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4显示文摘 | Wendt MA Mercurio AM | 2002 | Cancer Res2002，62，24： | 1 |
| 8 | Vascular endothelial growth factor promotes carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4显示文摘 | Bachelder RE Wendt MA Mercurio Am | 2002 | Cancer Res2002，62，24： | 1 |
| 9 | Gene sequence and trainaincdifference in 70KD heat shock protein correlated with urine virulence of Toxoplasma gondii显示文摘 | Johnson AM | 1998 | Int J Parasitol1998，28，： | 1 |
| 10 | Partial nephrectomy and radical nephrectomy offer similar cancer outcomes in renal cortical tumors 4cm or larger显示文摘 | Mitchell RE Gilbert SM Murphy AM | 2006 | Urology2006，67，2： | 1 |
| 11 | Potentially lethal com- plications of central venous catheter placement 显示文摘 | Bagwell CE Salzberg AM Sonnino RE | 2000 | J Pediatr Surg2000，35，5： | 1 |
| 12 | A randomized-controlled clinical trial evaluating clinical and radiological outcomes after 3 and 5 years of dental implants placed in bone regenerated by means of GBR techniques with or without the addition of BMP-2显示文摘 | Jung RE Windisch SI Eggenschwiler AM | 2009 | Clin Oral Implants Res2009，20，7： | 1 |
| 13 | Partial nephrectomy and radical nephrectomy offer similar cancer out- comes in renal cortical tumors 4 em or larger显示文摘 | MITCHELL RE GILBERT SM MURPHY AM | 2006 | Urology2006，67，2： | 1 |
| 14 | Intracellularly degradable polyelectrolyte microcapsules 显示文摘 | DE GEEST BG VANDENBROUCKE RE GUENTHER AM | 2006 | Adv Mater2006，18，8： | 1 |
| 15 | The detection of circulating breast cancer cells in blood显示文摘 | Gilbey AM Burnett D Coleman RE | 2004 | J Clin Pathol2004，57，9： | 1 |
| 16 | Risk factors for child neglect显示文摘 | Schumacher JA Slep AM Heyman RE | 2001 | Aggress Violent Beh2001，6，2： | 1 |
| 17 | Randomized trial of 3- hour versus 24-hour infusion of high-dose paelitaxel in patients with metastatic or locally advanced breast cancer: national surgical adjuvant breast and bowel project protocol B-26显示文摘 | Smith RE Brown AM Mamounas EP | 1999 | J ClinOneol1999，17，11： | 1 |
| 18 | Risk factors for childneglect 显示文摘 | Schumacher JA Slep AM Heyman RE | 2001 | Aggression Violent Behavior2001，6，2： | 1 |
| 19 | A syndrome of seronegative enthesopathy and arthropathy in children Arthritis 显示文摘 | Rosenbery AM Petty RE | 1982 | Rheum1982，25，： | 1 |
| 20 | Nerve growth factor antiserum induces axotomy-like changes in neuropeptide expression in intact sympathetic and sensory neurons显示文摘 | Shadiack AM Sun Y Zigmond RE | | 0，，： | 1 |
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