|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cardioprotection and pharmacological therapies in acute myocardial infarction: Challenges in the current era显示文摘In patients with an acute ST-segment elevation myocardial infarction, timely myocardial reperfusion using primary percutaneous coronary intervention is the most effective therapy for limiting myocardial infarct size, preserving left-ventricular systolic function and reducing the onset of heart failure. Within minutes after the restoration of blood flow, however, reperfusion itself results in additional damage, also known as myocardial ischemia-reperfusion injury. An improved understanding of the pathophysiological mechanisms underlying reperfusion injury has resulted in the identification ofseveral promising pharmacological(cyclosporin-A, exenatide, glucose-insulin-potassium, atrial natriuretic peptide, adenosine, abciximab, erythropoietin, metoprolol and melatonin) therapeutic strategies for reducing the severity of myocardial reperfusion injury. Many of these agents have shown promise in initial proofof-principle clinical studies. In this article, we review the pathophysiology underlying myocardial reperfusion injury and highlight the potential pharmacological interventions which could be used in the future to prevent reperfusion injury and improve clinical outcomes in patients with coronary heart disease. | Alberto Dominguez-Rodriguez Pedro Abreu-Gonzalez Russel J Reiter | 2014 | World Journal of Cardiology2014，6，3： | 18 |
| 2 | Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats显示文摘瞄准:决定 melatonin 预告的处理的效果并且在 L 精氨酸(L-Arg ) 的严厉上处理以后在老鼠的导致的试验性的胰腺炎。方法:男 Wistar 老鼠(25 ) 被划分成五个组。那些在 1h 的间隔在组 A 收到了 3.2g/kg 体重 L-Arg i.p 的二注射。在组麻省,老鼠与 50 mg/kg 体重 melatonin i.p 被对待在 L-Arg 管理以前的 30 min。在组 AM,在 L-Arg 被给以后,老鼠收到了 melatonin 1h 的一样的剂量。在组 M, melatonin 的单次量是以前描述了被管理。在组 C,对照动物收到了生理盐水注射 i.p 所有老鼠被给在第二 L-Arg 注射以后的 24 h。结果:引起严重引起坏死胰腺炎的 L-Arg 管理在浆液淀粉酶水平,胰腺的重量 / 身体重量比率(pw/bw ) ,胰腺的 IL-6 内容和 myeloperoxidase 由重要举起证实了活动,相对控制值。浆液淀粉酶水平的举起显著地在与仅仅与 L-Arg 注射的老鼠相比给 melatonin 追随者 L-Arg 的老鼠被减少。胰腺的抗氧化剂酶(Cu/Zn-superoxide 歧化酶(Cu/Zn-SOD ) 和过氧化氢酶(猫)) 的活动显著地被增加在胰腺炎以后的 24 h 感应。显著地在 L-Arg 之前给的 Melatonin 在独自与 L-Arg 对待的老鼠相对那减少了胰腺的猫活动。在肝, L-Arg 显著地每氧化水平,和谷胱甘肽过氧化物酶和 Cu/Zn-SOD 活动增加了类脂化合物,而 Mn 草皮活动作为与控制老鼠相比被减少。Melatonin 预告的处理阻止了这些变化。结论:Melatonin 是能在尖锐胰腺炎期间抵抗一些 L-Arg-induced 变化的一种抗氧化剂,并且可能因此在有尖锐引起坏死胰腺炎的病人的支持的治疗有用。 | Annamaria Szabolcs Russel J Reiter Tamas Letoha Peter Hegyi Gabor Papai Ilona Varga Katalin Jarmay Jozsef Kaszaki Reka Sari Zoltan Rakonczay Jr Janos Lonovics Tamas Takacs | 2006 | World Journal of Gastroenterology2006，12，2： | 13 |
| 3 | Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia显示文摘AIM:To evaluate blood concentration of melatonin and urinary excretion of its metabolite,6-sulfatoxymelatonin(6-OHMS),in functional dyspepsia(FD).METHODS:Ninety individuals were enrolled in the study:30 in each study group:patients with postprandial distress syndrome(PDS),epigastric pain syndrome(EPS),and controls.Blood samples were drawn at 02:00 and 09:00 h and 24-h urine collection was performed.Serum melatonin and urinary 6-OHMS concentrations were measured by enzyme-linked immunosorbent assay.RESULTS:Serum melatonin concentration at night and in the morning was significantly(P < 0.001) higher in PDS patients [at 02:00 h-93.3 pg/mL,quartile range(QR):79.8-116.2;at 09.00 h-14.3 pg/mL,QR:7.06-19.0] than in EPS(57.2 pg/mL,QR:42.6-73.1;8.1 pg/mL,QR:4.1-9.3) and control patients(57.7 pg/mL,QR:51.2-62.5;8.1 pg/mL,QR:5.4-10.3).A similar relationship was observed for urinary 6-OHMS excretion.Patients with severe PDS symptoms had a higher melatonin concentration than these with moderate syndromes,whereas patients with severe EPS had a lower urinary 6-OHMS excretion than patients with moderate symptoms.CONCLUSION:Evaluation of melatonin serum concentrations and 24-h urinary 6-OHMS excretion are useful methods for differential diagnosis of various clinical forms of FD. | Cezary Chojnacki Tomasz Poplawski Grazyna Klupinska Janusz Blasiak Jan Chojnacki Russel J Reiter | 2011 | World Journal of Gastroenterology2011，17，21： | 8 |
| 4 | Evaluation of enterochromaffin cells and melatonin secretion exponents in ulcerative colitis显示文摘AIM: To study an assessment of the number of enterochromaffin cells and expression of hydroxyindole-Omethyltransferase in colonic mucosa and urine excretion of 6-sulfatoxymelatonin in patients with ulcerative colitis. METHODS: The study included 30 healthy subjects (groupⅠ-C), 30 patients with ulcerative proctitis [group Ⅱ-ulcerative proctitis (UP)] and 30 patients with ulcerative colitis [group Ⅲ-ulcerative colitis (UC)] in acute phases of these diseases. The number of enterochromaffin cells (EC) was estimated in rectal and colonic mucosa. Bioptates were assembled from many different parts of the large intestine. Immunorective cells collected from various parts of the colon were counted according to the Eurovision DAKO (Dako A/S, Copenhagen, Denmark) System in the range of 10 fields in each bioptate at × 200 magnification. The level of mRNA expression of hydroxyindole-O-methyltransferase (HIOMT) in colonic mucosa was estimated with RT-PCR. Urine 6-sulfatoxymelatonin (6-HMS) excretion was determined immunoenzymatically using an IBL (IBL International GmbH, Hamburg, Germany) kit (RE 54031). RESULTS: The number of EC cells in healthy subjects (C) was 132.40 ± 31.26. In patients of group Ⅱ (UP) and group Ⅲ (UC) the number of these cells was higher 225.40 ± 37.35 (P < 0.001) and 225.24 ± 40.50 (P < 0.001) respectively. Similar differences were related to HIOMT expression, which was 1.04 ± 0.36 in group C, 1.56 ± 0.56 (P < 0.01) in group UP and 2.00 ± 0.35 (P < 0.001) in group UC. Twenty-four hour 6-HMS urinary excretion was as follows: C 16.32 ± 4.95 μg/24 h, UP 26.30 ± 7.29 μg/24 h (P < 0.01), UC 42.30 ± 12.56 μg/24h (P < 0.001). A correlation between number of EC cells and 6-HMS excretion was noted in all groups: r = 0.766 in patients with UP, r = 0.703 with UC and r = 0.8551 in the control group; the correlation between the results is statistically significant. CONCLUSION: In the acute phases of both UP and UC, proliferation of EC cells and high expression of HIOMT and urine excretion of 6-HMS is noted. These changes may represent a beneficial response in the anti-inflammatory and defense mechanism. | Cezary Chojnacki Maria Wisniewska-Jarosińska Grazyna Kulig Ireneusz Majsterek Russel J Reiter Jan Chojnacki | 2013 | World Journal of Gastroenterology2013，19，23： | 5 |
| 5 | 小剂量肾上腺素推注治疗PICU内急性低血压显示文摘目的了解低剂量肾上腺素推注在危重患儿急性低血压发作或心脏骤停前期的使用情况。设计机构审查委员会批准,单中心回顾性医学病历分析。场所一家独立三级儿童医院内的大型内外科综合性PICU。对象2015年6月1日至2016年6月1日间入住PICU且静脉推注低剂量肾上腺素(≤5mcg/kg)患儿。 | Reiter PD Roth J Wathen B 方伯粱 钱素云 | 2018 | 中国小儿急救医学2018，25，3： | 2 |
| 6 | Austenite Grain Size in the Continuous Casting Proeess显示文摘 | Reiter J Bernhard C Presslinger H | 2008 | Metallographic Methods and Evaluation Materials Characterization2008，59，6： | 1 |
| 7 | Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and or paracrine substance显示文摘 | Carrillo-Vieo A Cairo JR Abreu P Lardone PJ Garcia-Maurino S Reiter R J | 2004 | FASEB J2004，18，3： | 1 |
| 8 | The primary cilium as the cell's antenna:signaling at a sensory organelle显示文摘 | Singla V Reiter J F | 2006 | Science2006，313，5787： | 1 |
| 9 | Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology 显示文摘 | Reiter R J Dun XT Korkmaz A | 2014 | Hum Reprod Update2014，20，2： | 1 |
| 10 | An admissions OSCE : the multiple mini-interview 显示文摘 | Eva KW Rosenfeld J Reiter HI | 2004 | Med Edu2004，38，： | 1 |
| 11 | Melatonin directly scavenges hydrogen peroxide: a potentially new metabolic pathway of melatonin biotransformation 显示文摘 | Tan D X Manchester L C Reiter R J | 2000 | Free Radic Biol Med2000，29，11： | 1 |
| 12 | GATA5 is required for the development of the heart and endoderm in Zebrafish显示文摘 | Reiter JF Alexander J Rodaway A | 1999 | Genes Dev1999，13，22： | 1 |
| 13 | Thiazolidinedione drugs block cardi- ac KATP channels and may increase propensity for ischaemic ven- trieular fibrillation in pigs显示文摘 | Lu L Reiter M J Xu Y | 2008 | Diabetologia2008，51，4： | 1 |
| 14 | Oxidation Tuning in MCrN Coatings显示文摘 | Endrino J L Fox-Rabinovich G S Reiter A | 2007 | Surface & Coatings Technolo- gy2007，201，8： | 1 |
| 15 | Oxidative processes and antioxidative defense mechanisms in the aging brain显示文摘 | Reiter R J | 1995 | FASEB J1995，9，： | 1 |
| 16 | Prophylactic actions of melatonin in oxidative neurotoxicity显示文摘 | Reiter R J Guerrero J M Escames G | 1997 | Ann N Y Acad Sci1997，825，2： | 1 |
| 17 | Melatonin as a radioprotective agent:a review显示文摘 | VIJAYALAXMI REITER R J TAN D X | 2004 | Int J Radiat Oncol Biol Phys2004，59，3： | 1 |
| 18 | Significance of melatonin in antioxidative defense system:reactions and products显示文摘 | Tan D X Lucien C M Reiter R J | 2000 | Biol Signal Recept2000，9，： | 1 |
| 19 | Inhibitory effect of melatonin on products of lipid peroxidation resulting from chronic ethanol administration 显示文摘 | El Sokkary G Reiter H Tan R J | 1999 | Alcohol1999，34，6： | 1 |
| 20 | Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13) (p11;q12) myeloproliferative syndrome显示文摘 | Reiter A Sohal J Kulkarni S | | 0，，05： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员