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| 1 | Primary arthroplasty is better than internal fixation of displaced femoral neck fractures:a meta-analysis of 14randomized studies with 2,289 patients显示文摘 | Remark C Johnell O | 2006 | Act Orthop2006，77，3： | 1 |
| 2 | The immune microenvironment :a major player in human cancers显示文摘 | Fridman WH Remark R Goc J | 2014 | Int Arch Allergy Immunol2014，164，1： | 1 |
| 3 | Ein beitrag zur entwickelungsgeschichte der krebshaften geschwulste显示文摘 | Remark R | | Deut Klin0，6，： | 1 |
| 4 | The immune microenviroment: a major player in human cancers显示文摘 | Fridaman WH Remark R Goc J | 2014 | Int Allergy Immunol2014，164，1： | 1 |
| 5 | Properties of Human Ecosystems显示文摘 | Step J R Remarkable | | 0，，03： | 1 |
| 6 | Magnetic resonance imaging of renal oncocytoma显示文摘 | Remark RR Berquist TH Lieber MM | 1988 | Urology1988，31，2： | 1 |
| 7 | The immune microenvironment: a major player in human cancers显示文摘 | Fridman WH Remark R Goc J | 2014 | Int Arch Allergy Immunol2014，164，1： | 1 |
| 8 | Germinal center-dependent and-independent immune responses of tumor-infiltrating B cells in human cancers显示文摘B cells play essential roles in immunity,mainly through the production of high affinity plasma cells(PCs)and memory B(Bmem)cells.The affinity maturation and differentiation of B cells rely on the integration of B-cell receptor(BCR)intrinsic and extrinsic signals provided by antigen binding and the microenvironment,respectively.In recent years,tumor infiltrating B(TIL-B)cells and PCs(TIL-PCs)have been revealed as important players in antitumor responses in human cancers,but their interplay and dynamics remain largely unknown.In lymphoid organs,B-cell responses involve both germinal center(GC)-dependent and GC-independent pathways for Bmem cell and PC production.Affinity maturation of BCR repertoires occurs in GC reactions with specific spatiotemporal dynamics of signal integration by B cells.In general,the reactivation of high-affinity Bmem cells by antigens triggers GC-independent production of large numbers of PC without BCR rediversification.Understanding B-cell dynamics in immune responses requires the integration of multiple tools and readouts such as single-cell phenotyping and RNA-seq,in situ analyses,BCR repertoire analysis,BCR specificity and affinity assays,and functional tests.Here,we review how those tools have recently been applied to study TIL-B cells and TIL-PC in different types of solid tumors.We assessed the published evidence for different models of TIL-B-cell dynamics involving GC-dependent or GC-independent local responses and the resulting production of antigen-specific PCs.Altogether,we highlight the need for more integrative B-cell immunology studies to rationally investigate TIL-B cells as a leverage for antitumor therapies. | Eve Playoust Romain Remark Eric Vivier Pierre Milpied | 2023 | Cellular & Molecular Immunology2023，20，9： | 0 |
| 9 | They Swam the Yangtze显示文摘FORTY-FIVE^YEAR^OLDZhangMianisI.75meterstallandweighs70kilograms.ThisdriverandveteranmemberoftheWinterSwimmingAssociationhailsfromNejianginSichuanProvinceandhaspracticedwinterswimmingfor13years.Hispanef,43-year-oldLuoDesong,isabitshorterandstockierat... | Zhang Mian and Luo Desong reached the mouth of the Yangtze River on August 18, 1998, capping a remarkable odyssey.By TANG TANFENG | 1999 | China Today1999，48，1： | 0 |
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