| 1 | Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B:a multi-center retrospective cohort study显示文摘The coronavirus disease 2019(COVID-19)has spread globally.Although mixed liver impairment has been reported in COVID-19 patients,the association of liver injury caused by specific subtype especially chronic hepatitis B(CHB)with COVID-19 has not been elucidated.In this multi-center,retrospective,and observational cohort study,109 CHB and 327 non-CHB patients with COVID-19 were propensity score matched at an approximate ratio of 3:1 on the basis of age,sex,and comorbidities.Demographic characteristics,laboratory examinations,disease severity,and clinical outcomes were compared.Furthermore,univariable and multivariable logistic and Cox regression models were used to explore the risk factors for disease severity and mortality,respectively.A higher proportion of CHB patients(30 of 109(27.52%))developed into severe status than non-CHB patients(17 of 327(5.20%)).In addition to previously reported liver impairment markers,such as alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,and total bilirubin,we identified several novel risk factors including elevated lactate dehydrogenase(≥245 U/L,hazard ratio(HR)=8.639,95%confidence interval(CI)=2.528–29.523;P<0.001)and coagulation-related biomarker D-dimer(≥0.5μg/mL,HR=4.321,95%CI=1.443–12.939;P=0.009)and decreased albumin(<35 g/L,HR=0.131,95%CI=0.048–0.361;P<0.001)and albumin/globulin ratio(<1.5,HR=0.123,95%CI=0.017–0.918;P=0.041).In conclusion,COVID-19 patients with CHB were more likely to develop into severe illness and die.The risk factors that we identified may be helpful for early clinical surveillance of critical progression. | Jing Wang Zequn Lu Meng Jin Ying Wang Kunming Tian Jun Xiao Yimin Cai Yanan Wang Xu Zhang Tao Chen Zhi Yao Chunguang Yang Renli Deng Qiang Zhong Xiongbo Deng Xin Chen Xiang-ping Yang Gonghong Wei Zhihua Wang Jianbo Tian Xiao-ping Chen | 2022 | Frontiers of Medicine2022，16，1： | 0 |
| 2 | The First Reported Case of COVID-19 and Plasmodium ovale Malaria Coinfection—Guangdong Province,China,January 2021显示文摘The current coronavirus disease 2019(COVID-19)pandemic has posed an unprecedented challenge to global health(1–3).The clinical symptoms of COVID-19 are similar to those of malaria,such as fever,myalgia,fatigue,headache,and gastrointestinal symptoms.Due to the heavy burden of medical services and the possible shortage of resources caused by the long-term COVID-19 pandemic,the risk of coinfection of malaria and COVID-19 is a matter of particular concern.Here we reported the first case of COVID-19 coinfection with Plasmodium ovale(P.ovale)malaria in a 47-year-old man who had been previously diagnosed with Plasmodium infection and incompletely treated with antimalarial drugs. | Muxin Chen Shitong Gao Lin Ai Jiaxu Chen Tiejian Feng Zhigao Chen Xiaomin Zhang Shaoyu Deng Zidan Lin Yijun Tang Qian Zhang Gengcheng He Huawei Xiong Xiao-nong Zhou Renli Zhang Dana Huang | 2021 | China CDC weekly2021，3，21： | 0 |
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