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| 1 | 致病的概念和胆石病的治疗显示文摘 Gallstone disease(GD) is a chronic recurrent hepatobiliary disease,the basis for which is the impaired metabolism of cholesterol,bilirubin and bile acids,which is characterized by the formation of gallstones in the hepatic bile duct,common bile duct,or gallbladder.GD is one of the most prevalent gastrointestinal diseases with a substantial burden to health care systems.GD can result in serious outcomes,such as acute gallstone pancreatitis and gallbladder cancer.The epidemiology,pathogenesis and treatment of GD are discussed in this review.The prevalence of GD varies widely by region.The prevalence of gallstone disease has increased in recent years.This is connected with a change in lifestyle:reduction of motor activity,reduction of the physical load and changes to diets.One of the important benefits of early screening for gallstone disease is that ultrasonography can detect asymptomatic cases,which results in early treatment and the prevention of serious outcomes.The pathogenesis of GD is suggested to be multifactorial and probably develops from complex interactions between many genetic and environmental factors.It suggests that corticosteroids and oral contraceptives,which contain hormones related to steroid hormones,may be regarded as a model system of cholelithiasis development in man.The achievement in the study of the physiology of bile formation and the pathogenesis of GD has allowed expanding indications for therapeutic treatment of GD. | Vasiliy Ivanovich Reshetnyak | 2012 | World Journal of Hepatology2012，4，2： | 39 |
| 2 | Significance of dormant forms of Helicobacter pylori in ulcerogenesis显示文摘Nearly half of the global population are carriers of Helicobacter pylori(H. pylori),a Gram-negative bacterium that persists in the healthy human stomach. H. pylori can be a pathogen and causes development of peptic ulcer disease in a certain state of the macroorganism. It is well established that H. pylori infection is the main cause of chronic gastritis and peptic ulcer disease(PUD). Decontamination of the gastric mucosa with various antibiotics leads to H. pylori elimination and longer remission in this disease. However,the reasons for repeated detection of H. pylori in recurrent PUD after its successful eradication remain unclear. The reason for the redetection of H. pylori in recurrent PUD can be either reinfection or ineffective anti-Helicobacter therapy. The administration of antibacterial drugs can lead not only to the emergence of resistant strains of microorganisms,but also contribute to the conversion of H. pylori into the resting(dormant) state. The dormant forms of H. pylori have been shown to play a potential role in the development of relapses of PUD. The paper discusses morphological H. pylori forms,such as S-shaped,C-shaped,U-shaped,and coccoid ones. The authors proposes the classification of H. pylori according to its morphological forms and viability. | Vasiliy Ivanovich Reshetnyak Tatiana Magomedalievna Reshetnyak | 2017 | World Journal of Gastroenterology2017，23，27： | 19 |
| 3 | Primary biliary cirrhosis: Clinical and laboratory criteria for its diagnosis显示文摘Primary biliary cirrhosis(PBC) is a chronic progressive cholestatic granulomatous, and destructive inflammatory lesion of small intralobular and septal bile ducts, which is likely to be caused by an autoimmune mechanism with a the presence of serum antimitochondrial antibodies and a potential tendency to progress to cirrhosis. Despite the fact that the etiology of this disease has beenunknown so far, there has been a considerable body of scientific evidence that can reveal the clinical and laboratory signs of PBC and the individual components of its pathogenesis and elaborate diagnostic criteria for the disease and its symptomatic therapy. Deficiencies in autoimmune tolerance are critical factors for the initiation and perpetuation of the disease. The purpose of this review is to summarize the data available in the literature and the author's findings on clinical and laboratory criteria for the diagnosis of PBC. This review describes the major clinical manifestations of the disease and the mechanisms of its development. It presents the immunological, biochemical, and morphological signs of PBC and their significance for its diagnosis. A great deal of novel scientific evidence for the problem of PBC has been accumulated. However, the inadequate efficiency of therapy for the disease lends impetus to the quest for its etiological factors and to further investigations of its pathogenetic mechanisms and, on this basis, to searches for new methods for its early diagnosis. | Vasiliy Ivanovich Reshetnyak | 2015 | World Journal of Gastroenterology2015，21，25： | 19 |
| 4 | Concept on the pathogenesis and treatment of primary biliarycirrhosis显示文摘Primary biliary cirrhosis (PBC) is an organ-specific autoimmune disease that predominantly affects women and is characterized by chronic, progressive destruction of small intrahepatic bile ducts with portal inflammation and ultimately fibrosis, leading to liver failure in the absence of treatment. Little is known about the etiology of PBC. PBC is characterized by anti-mitochondrial antibodies and destruction of intrahepatic bile ducts. The serologic hallmark of PBC is the presence of auto-antibodies to mitochondria, especially to the E2 component of the pyruvate dehydrogenase complex (PDC). Current theories on the pathogenesis of PBC favor the hypothesis that the disease develops as a result of an inappropriate immune response following stimulation by an environmental or infectious agent. Some reports suggest that xenobiotics and viral infections may induce PBC. The pathogenetic mechanism is believed to be caused by a defect in immunologic tolerance, resulting in the activation and expansion of self-antigen specific T and B lymphocyte clones and the production of circulating autoantibodies in addition to a myriad of cytokines and other inflammatory mediators. This leads to ductulopenia and persistent cholestasis, by developing end-stage hepatic-cell failure. In this review are given our own and literary data about mechanisms of development of intrahepatic cholestasis and possible ways of its correction. | Vasiliy Ivanovich Reshetnyak | 2006 | World Journal of Gastroenterology2006，12，45： | 10 |
| 5 | Hepatitis G virus显示文摘A number of new hepatitis viruses (G, TT, SEN) were discovered late in the past century. We review the data available in the literature and our own findings suggesting that the new hepatitis G virus (HGV), disclosed in the late 1990s, has been rather well studied. Analysis of many studies dealing with HGV mainly suggests the lymphotropicity of this virus. HGV or GBV-C has been ascertained to influence course and prognosis in the HIV-infected patient. Until now, the frequent presence of GBV-C in coinfections, hematological diseases, and biliary pathology gives no grounds to determine it as an 'accidental tourist' that is of no significance. The similarity in properties of GBV-C and hepatitis C virus (HCV) offers the possibility of using HGV, and its induced experimental infection, as a model to study hepatitis C and to develop a hepatitis C vaccine. | Vasiliy Ivanovich Reshetnyak Tatiana Igorevna Karlovich Ljudmila Urievna Ilchenko | 2008 | World Journal of Gastroenterology2008，14，30： | 9 |
| 6 | Peripheral blood lymphocytes DNA in patients with chronic liver diseases显示文摘BACKGROUND Viral replication in blood cells with nucleuses may lead to the damage of lymphocytes genetic apparatus and the beginning of immunopathological reactions.AIM Of this investigation is to reveal the damage to peripheral blood lymphocytes (PBL)DNA in the patients with chronic liver diseases.MATERIALS AND METHODS Sixteen-ninepatients with chronic liver diseases (37 patients with chronic viral hepatitis, 2 patients with liver cirrhosis of mixed etiology (alcohol + virus G),30 women with primary biliary cirrhosis-PBC)were examined. The condition of DNA structure of PBL-was measured by the fluorescenceanalysis of DNA unwinding (FADU) technique with modification. Changes of fluorescence (in %) reflected the DNA distractions degree (thepresence of DNA single-stranded breaks and alkalinelabile sights).RESULTS AND CONCLUSION . The quantity of DNA single-stranded breaks and alkalinelabile sightsin DNA in all patients with chronic viral hepatitis .didnt differ from the control group,excluding the patients with chronic hepatitis (CH) C + G. Patients with HGV and TTV monoinfection had demonstrated the increase of the DNA single-stranded breaks PBL quantity.This fact may be connected with hypothesisabout the viruses replication in white blood cells discussed in the literature. Tendency to increase quantity of DNA PBL damages in the patients with primary biliary cirrhosis (PBC) accordingly to the alkaline phosphatase activity increase was revealed. Significant decrease of the DNA single-stranded breaks and alkalinelabile sights in the PBC patients that were treated with prednison was demonstrated. Probably, the tendency to increase the quantity of DNA singlestranded breaks and alkalinelabile sights in lymphocytes of the PBC patients was depended on the surplus of the blood bile acid content. | Vasiliy I Reshetnyak Tatyana I Sharafanova Ludmila U Ilchenko Elena V Golovanova Gennadiy G Poroshenko | 2001 | World Journal of Gastroenterology2001，7，2： | 6 |
| 7 | Physiological and molecular biochemical mechanisms of bile formation显示文摘This review considers the physiological and molecular biochemical mechanisms of bile formation.The composition of bile and structure of a bile canaliculus,biosynthesis and conjugation of bile acids,bile phospholipids,formation of bile micellar structures,and enterohepatic circulation of bile acids are described.In general,the review focuses on the molecular physiology of the transporting systems of the hepatocyte sinusoidal and apical membranes.Knowledge of physiological and biochemical basis of bile formation has implications for understanding the mechanisms of development of pathological processes,associated with diseases of the liver and biliary tract. | Vasiliy Ivanovich Reshetnyak | 2013 | World Journal of Gastroenterology2013，19，42： | 6 |
| 8 | Helicobacter pylori:Commensal,symbiont or pathogen?显示文摘This review considers the data on Helicobacter pylori(H.pylori),which have been accumulated over 40 years since its description as an etiological factor in gastrointestinal diseases.The majority of modern publications are devoted to the study of the pathogenic properties of the microorganism in the development of chronic gastritis,peptic ulcer disease,and gastric cancer,as well as methods for its eradication.However,in recent years,there have been more and more studies which have suggested that H.pylori has a beneficial,or potentially positive,effect on the human body.The authors have attempted to objectively analyze the information accumulated in the literature on H.pylori.Some studies consider it as one of the recently identified human bacterial pathogens,and special attention is paid to the evidence suggesting that it is probably part of the composition of the human microbiome as a commensal(commensal from French to English is a table companion)or even a symbiont.The presented data discussing the presence or absence of the effect of H.pylori on human health suggest that there is an apparent ambiguity of the problem.The re-assessment of the data available on H.pylori infection is important in order to answer the question of whether it is necessary to create a program of mass H.pylori eradication or to apply a more personalized approach to treating patients with H.pylori-associated gastrointestinal diseases and to perform eradication therapy. | Vasiliy Ivanovich Reshetnyak Alexandr Igorevich Burmistrov Igor Veniaminovich Maev | 2021 | World Journal of Gastroenterology2021，27，7： | 4 |
| 9 | New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage显示文摘Primary biliary cholangitis(PBC)is a chronic cholestatic progressive liver disease and one of the most important progressive cholangiopathies in adults.Damage to cholangiocytes triggers the development of intrahepatic cholestasis,which progresses to cirrhosis in the terminal stage of the disease.Accumulating data indicate that damage to biliary epithelial cells[(BECs),cholangiocytes]is most likely associated with the intracellular accumulation of bile acids,which have potent detergent properties and damaging effects on cell membranes.The mechanisms underlying uncontrolled bile acid intake into BECs in PBC are associated with pH change in the bile duct lumen,which is controlled by the bicarbonate(HCO3-)buffer system“biliary HCO3-umbrella”.The impaired production and entry of HCO3-from BECs into the bile duct lumen is due to epigenetic changes in expression of the X-linked microRNA 506.Based on the growing body of knowledge on the molecular mechanisms of cholangiocyte damage in patients with PBC,we propose a hypothesis explaining the pathogenesis of the first morphologic(ductulopenia),immunologic(antimitochondrial autoantibodies)and clinical(weakness,malaise,rapid fatigue)signs of the disease in the asymptomatic stage.This review focuses on the consideration of these mechanisms. | Vasiliy Ivanovich Reshetnyak Igor Veniaminovich Maev | 2023 | World Journal of Gastroenterology2023，29，37： | 1 |
| 10 | Dielectric relaxation spectroscopy of a nematic liquid crystal doped with ferroelectric Sn2P2S6 nanoparticles显示文摘 | Ouskova E Buchnev O Reshetnyak V | 2003 | Liquid Crystals2003，30，10： | 1 |
| 11 | DNA Structure in Peripheral Blood Lymphocytes from Patients with Chronic Viral Liver Damages显示文摘 | V. I. Reshetnyak T. I. Sharafanova L. Yu. Il’chenko G. G. Poroshenko | 2002 | Bulletin of Experimental Biology and Medicine2002，，4： | 1 |
| 12 | Mechanism of interaction of electromagnetic radiation with a biosystem显示文摘 | Reshetnyak S A Shcheglov V A Blagodatskikh P P | 1996 | Laser Physics1996，6，2： | 1 |
| 13 | Detonation of emulsion explosives containing hollow microspheres显示文摘 | Deribas A A Medvedev A E Reshetnyak A Yu | | 0，，04： | 1 |
| 14 | Mechanical properties of hard metals and their erosive wear resistance 显示文摘 | Reshetnyak H Kuybarsepp J | 1994 | Wear1994，177，： | 1 |
| 15 | 查看详情显示文摘 | Cox S J Reshetnyak V Y Sluckin T J | | 0，，： | 1 |
| 16 | A possible role of Fas ligand-mediated 'reverse signaling' in pathogenesis of rheumatoid arthritis and systemic lupus erythematosus显示文摘 | Telegina E Reshetnyak T Moshnikova A | 2009 | Immunol Lett2009，122，： | 1 |
| 17 | Steviol glycoside content in different organs of Stevia rebaudiana and its dynamics during ontogeny显示文摘 | NI Bondarev MA Sukhanova OV Reshetnyak | 2003 | Biologia plantarum2003，47，2： | 1 |
| 18 | Steviol glycoside content in different organs of Stevia rebaudiana and its dynamics during ontogeny显示文摘 | Bondarev NL Sukhanova MA Reshetnyak OV | 2003 | Biologia Plantarum2003，47，2： | 1 |
| 19 | Detonation of emulsion explosives containing hollow microspheres显示文摘 | Deribas A A Medvedev A E Reshetnyak A Y | 2003 | Dokl Phys2003，389，： | 1 |
| 20 | Mechanism of detonation of emulsion explosives with microballoons显示文摘 | Medvedev A E Fomin V M Reshetnyak A Y | 2008 | Shock Waves2008，18，： | 1 |
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