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| 1 | Postoperative analgesic effects of celecoxb or rofecoxib after spinal Iusion surgery显示文摘 | Scott S Reuben M D Neil R C | 2000 | Anelsth Analg2000，9，： | 1 |
| 2 | Detection of incipient cavitation in pumps using acoustic emission显示文摘 | Neill G D Reuben R L Sandford P M | 1997 | Proc Imech E Part E: Journal of Process Mechanical Engineering1997，211，4： | 1 |
| 3 | Effects of Wheel-Rail Contact Geometry on Wheel Set Steering Forces显示文摘 | Stephen M Reuben D | 1996 | WEAR1996，，191： | 1 |
| 4 | A randomized trial comparing long-term and short-term use of umbilical venous catheters in premature in- fants with birth weights of less than 1251 grams显示文摘 | Butler-O'Hara M Buzzand CJ Reubens L McDermott MP Di- Grazio W D'Angio CT | 2006 | Pediatrics2006，118，1： | 1 |
| 5 | Drug-induced acute liver failure:results of a US muhicenter, prospective study 显示文摘 | REUBEN A KOCH D G LEE W M | 2010 | Hepa- tology2010，52，6： | 1 |
| 6 | A randomized trial of comprehensive geriatric assessment in the care of hospitalized patients显示文摘 | Reuben D B Borok G M Wolde-Tsadik G | 1995 | N Engl J Med1995，332，20： | 1 |
| 7 | Detection of incipient cavitation in pumps using acoustic emission 显示文摘 | Neill G D Reuben R L Sandford P M | 1997 | Proceedings of the Institution of Mechanical Engineers Part E: Journal of Process Mechanical Engineering1997，211，26： | 1 |
| 8 | The direct formation of functionalized alkyl(aryl)zinc halides by oxidative addition of highly reactive zinc with organic halides and their reactions with acid chlorides,α,β-unsaturated ketones,and allylic,aryl,and vinyl halides显示文摘 | Lishan Zhu Richard M Wehmeyer Reuben D Rieke | 1991 | Journal of Organic Chemistry1991，56，： | 1 |
| 9 | Detection of incipient cavitation in pumps using acoustic emission显示文摘 | Neill G D Reuben R L Sandford P M | 1997 | Proc IMech E Part E : Journal of Process Mechanical Engineering1997，211，4： | 1 |
| 10 | Evaluation of extraction protocols for anti-diabetic phytochemical substances from medicinal plants显示文摘AIM To examine the efficacy of three extraction techniques: Soxhlet-extraction(SE), cold-maceration(CM) and microwave-assisted-extraction(MAE) using 80% methanol as solvent. METHODS The study was performed on each of 50 g of Vernonia amygdalina(VA) and Occimum gratissimum(OG) leaves respectively. The percentage yield, duration of extraction, volume of solvent used, qualitative and quantitative phytoconstituents present was compared. The biological activities(hypoglycemic effect) were investigated using albino wistar rat model of diabetes mellitus(n = 36) with a combined dose(1:1) of the two plants leaf extracts(250 mg/kg b.w.) from the three methods. Theextracts were administered orally, once daily for 21 d.RESULTS In this report, the percentage VA extract yield from MAE was highest(20.9% ± 1.05%) within 39 min using 250 m L of solvent, when compared to the CM(14.35% ± 0.28%) within 4320 min using 900 m L of solvent and SE(15.75% ± 0.71%) within 265 min using 500 m L of solvent. The percentage differences in OG extract yield between: MAE vs SE was 41.05%; MAE vs CM was 46.81% and SE vs CM was 9.77%. The qualitative chemical analysis of the two plants showed no difference in the various phytoconstituents tested, but differs quantitatively in the amount of the individual phytoconstituents, as MAE had significantly high yield(P > 0.05) on phenolics, saponins and tannins. SE technique gave significantly high yield(P > 0.05) on alkaloid, while CM gave significant high yield on flavonoids. The extracts from CM exhibited a significantly(P > 0.05) better hypoglycemic activity within the first 14-d of treatment(43.3% ± 3.62%) when compared to MAE(36.5% ± 0.08%) and SE methods(33.3% ± 1.60%). However, the percentage hypoglycemic activity, 21 d post-treatment with 250 mg/kg b.w. extract from MAE was 72.6% ± 1.03% and it was more comparable to 10 mg/kg b.w. glibenclamide treated group(75.0% ± 0.73%), unlike the SE(69.5% ± 0.71%) and CM(69.1% ± 1.03%). CONCLUSION CM technique produces extract with better hypoglycemic activity, whereas; MAE is a better option for high yield of phytoconstituents using less solvent within a short time. | Stanley Irobekhian Reuben Okoduwa Ismaila A Umar Dorcas B James Hajara M Inuwa James D Habila | 2016 | World Journal of Diabetes2016，7，20： | 0 |
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