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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019,6,3: | 15 |
| 2 | Quality in the technical per- formance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the US Multi - Society Task Force on Colorectal Cancer显示文摘 | Rex D K Bond J H Winawer S | 2002 | The American journal of gastro- enterology2002,97,6: | 1 |
| 3 | Defining Opportunistic Invasive Fungal Infections in Immunocompromised Patients with Cancer and Hematopoietic Stem Cell Transplants: An International Consensus显示文摘 | Ascioglu S Rex J H PauwB de | 2002 | Clin Infect Dis2002,34,1: | 1 |
| 4 | Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants:An international consensus显示文摘 | Ascioglu S Rex J H de Pauw B | 2002 | Clin Infect Dis2002,34,1: | 1 |
| 5 | Solubility of COa in sulfonate ionic liquids at high pressure显示文摘 | Zhang S J Chen Y H Ren Rex X F | 2005 | J Chem Eng Data2005,50,1: | 1 |
| 6 | Defining opportunistic and hematopoietic stem cell transplants : all international consensus 显示文摘 | Ascioglu S Rex J H de Pauw B | 2002 | Clin Infect Dis2002,34,1: | 1 |
| 7 | Colorectal cancer screening and surveillance显示文摘 | Winawer S J Fletcher RH Rex D | 2003 | Gastroenterology2003,124,: | 1 |
| 8 | Guidelines for eolonoscopy surveillance after screening and polypectomy: a consensus update by the US Multi- Society Task Force on Colorectal Cancer 显示文摘 | LIEBENMAN D A REX D K WINAWER S J | 2012 | Gastroenterology2012,143,3: | 1 |
| 9 | Quality indicators for colonoscopy显示文摘 | REX D K SCHOENFELD P S COHEN J | 2015 | Gastrointest Endosc2015,81,1: | 1 |
| 10 | Trace analysis of bromate, chlorate, iodate, and perch- lorate in natural and bottled waters 显示文摘 | SNYDER S A VANDERFORD B J REXING D J | 2005 | Environ Sci Technol2005,39,: | 1 |
| 11 | Defining opportunistic invasive fungal infections in immune ocompromised patients with cancer and hematopoitic stem cell transplants: an intem-ational consensus 显示文摘 | ASCIOGLU S REX J H de PAUW B | 2002 | Clin Infect Dis2002,34,2: | 1 |
| 12 | Screening for Barrett’s esophagus in colonoscopy patients with and without heartburn显示文摘 | Douglas K Rex Oscar W Cummings Michael Shaw Mark D Cumings Roy K.H Wong Raj S Vasudeva Donal Dunne Emad Y Rahmani Debra J Helper | 2003 | Gastroenterology2003,,6: | 1 |
| 13 | Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus 显示文摘 | ASCIOGLU S REX J H PAUW B D | 2002 | Clin Infect Dis2002,34,5: | 1 |
| 14 | Quartz Isolation from Rocks,Sediments,and Soils for Determination of Oxygen Isotopic Composition显示文摘 | Syers J K Chapman S L Rex R W | 1986 | Geochimica et Cosmochimica Acta1986,32,: | 1 |
| 15 | Ozone oxidation of endocrine disruptors and pharmaceuticals in surface water and wastewater显示文摘 | SNYDER S A WERT E C REXING D J | 2006 | Ozone:Science and Engineering2006,28,6: | 1 |
| 16 | Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus 显示文摘 | Ascioglu S Rex J H de Pauw B | 2002 | Clin Infect Dis2002,34,1: | 1 |
| 17 | Quartz isolation from rocks, sediments, and soils for determination of oxygen isotopic composition 显示文摘 | Syers J K Chapman S L Jackson M L Rex R W Clayton R N | 1968 | Geochimica et Cosmochimica Acta1968,32,9: | 1 |
| 18 | Guidelines for eolonoscopy surveillance after screening and polypeetomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer显示文摘 | Lieberman DA Rex DK Winawer S J | 2012 | Gestroenterology2012,143,: | 1 |
| 19 | Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and he matopoietic cell transplants:an international consensus显示文摘 | Ascioglu S Rex J H de Pauw B | 2002 | Clin Infect Dis2002,34,1: | 1 |
| 20 | Heat stress and seasonal effects on reproduction in the dairy cow a review显示文摘 | Fabio D R Rex J S | 2003 | Theriogenology2003,60,: | 1 |