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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | A hysteretic model for a vanadium dioxide transitionedge microbolometer显示文摘 | de Almeida L A L L Deep G S Lima A M N | 2001 | IEEE Trans Instrum Meas2001，50，4： | 2 |
| 3 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 4 | Bone marrow transplantation after failure of autolo-gous transplant for non-Hodgkin’s lymphoma显示文摘 | DE LIMA M VAN BESIEN K W GIRALT S A etal | 1997 | Bone Marrow Transplant1997，19，： | 1 |
| 5 | Serolog- ic marker candidates among B-cell linear epitopes of Nsp2 and structural proteins of a North American strain of porcine re- productive and respiratory syndrome virus 显示文摘 | DE LIMA M PATTNAIK A K FLORES E F | 2006 | Virology2006，353，2： | 1 |
| 6 | Study of catalyst deactivation and reaction mechanism of steam reforming,partial oxidation,and oxidative steam reforming of ethanol over Co/CeO2 catalyst显示文摘 | de Lima S M da Silva A M da Costa L O O | 2009 | J Catal2009，268，2： | 1 |
| 7 | Prevalence and nonrandom distribution of exonic mutations in inter-feron regulatory factor 6 in 307 families with Van der Woude syndrome and 37 families with popliteal pterygium syndrome显示文摘 | de LIMA R L HOPER S A GHASSIBE M | 2009 | Genet Med2009，11，： | 1 |
| 8 | Particle filter with differential evolution for trajecttry tracking 显示文摘 | DE LIMA L M KROHLING R A | 2011 | Advances in Intelligent and Soft Computing2011，96，1： | 1 |
| 9 | A grain conductivity approch to shaly sandstones显示文摘 | Olivar A L De Lima Mukul M | 1990 | Geophysics1990，55，10： | 1 |
| 10 | Serologic marker candidates identified among B-cell linear epitopes of Nsp2 and structural proteins of a North American strain of porcine reproductive and respiratory syndrome virus显示文摘 | DE LIMA M PATTNAIK A K FLORES E F | 2006 | Virol- ogy2006，353，2： | 1 |
| 11 | MS222 does not induce primary DNA damage in fish显示文摘 | BARRETO R E GONTIJO A M M C ALVES - DE - LIMA R O | 2007 | Aquac2007，15，2： | 1 |
| 12 | Impact of genetically modified Enterobacter cloacae on indigenous endophytic community of Citrus sinensis seedlings显示文摘 | Andreote F D Gullo M J M de Souza Lima A O | 2004 | Journal of Microbiology2004，42，3： | 1 |
| 13 | Serologic marker candidates identified among B-cell linear epitopes of Nsp2 and structural proteins of a North American strain of porcine repro ductive and respiratory syndrome virus显示文摘 | De Lima M Pattnaik A K Flores E F | 2006 | Virology2006，353，： | 1 |
| 14 | Chemical and morphological characterization of sugarcane bagasse submitted to a delignification process for enhanced enzymatic digestibility 显示文摘 | REZENDE C A de LIMA M A MAZIERO P DEAZEVEDO E R GARCIA W POLIKARPOV L | 2011 | Biotechnology for Biofuels2011，4，1： | 1 |
| 15 | Serologic marker candidates identified among B-cell linear epitopes of Nsp2 and structural proteins of a North American strain of porcine reproductive and respiratory syndrome virus显示文摘 | de Lima M Pattnaik A K Flores E F | 2006 | Virology2006，353，2： | 1 |
| 16 | New approaches to improving catalyst stability over Pt/ceria during ethanol steam reforming: Sn addition and CO2 co-feeding 显示文摘 | de Lima S M da Silva A M Jacobs G | 2010 | Applied Catalysis B: Environmental2010，96，34： | 1 |
| 17 | Purification, partial characterization, and covalent immobilization?stabilization of an extracellular o-umylase from Aspergillus niveus显示文摘 | Silva T M de Lima Damcsio A R Maller A | 2013 | Folia Microbiologica2013，，3： | 1 |
| 18 | Fault tolerant reversible AC motor drive system 显示文摘 | Jacobina C B de Araujo Ribeiro R L Lima A M N | 2003 | IEEE Transactions on Industry Applications2003，39，4： | 1 |
| 19 | 查看详情显示文摘 | Lima A M F de Castro V G Borges R S Silva G G | | 0，，02： | 1 |
| 20 | Benefits of soy isoflavone therapeutic regimen on menopausal symptoms显示文摘 | Han K K Soares J M Haidar M A Rodrigues de Lima G Baracat E C | 2002 | Obstet Gynecol2002，99，3： | 1 |
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