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| 1 | 糖尿病视网膜病变患者玻璃体样本中白细胞介素-8和肿瘤坏死因子-α水平(英文)显示文摘目的:测量糖尿病性视网膜病变(DR)行玻璃体切除术(PPV)患者玻璃体样品中白细胞介素-8(IL-8),肿瘤坏死因子-α(TNF-α)的水平,与对照组比较结果并探讨其对DR的影响。方法:将伊斯坦布尔Bilim大学眼科系的57例(57眼)DR患者和22例黄斑裂孔未伴有增生性玻璃体视网膜病变患者分为研究组和对照组。对所有79例患者行3切口,20G PPV。PPV手术眼内灌注前,用Vitrector抽吸0.5mL玻璃体样品并稀释。样品转至冷藏室,存放在-70℃。IL-8和TNF-α的测量结果用酶联免疫吸附法以pg/mL为单位计算。结果:DR患者玻璃体样本中IL-8水平[82.7891±74.08700(0.08-307.09)pg/mL]明显高于对照组患者[2.9805±3.77546(0.08-18.53)pg/mL](P<0.001)。同样,DR患者TNF-α水平[18.0007±13.90015(2.32-51.11)pg/mL]也显着高于对照组[1.7005±1.26949(0.1-5.17)pg/mL](P<0.001)。结论:在视网膜新生血管形成中起重要作用的TNF-α和作为炎症和血管生成介体的IL-8水平在DR患者玻璃体样本中明显高。 | Rifat Rasier Ozgur Artunay Uzay Gormus Erdal Yuzbasioglu Alper Sengul Amber Senel Kukner Murat Oncel Halil Bahcecioglu | 2013 | 国际眼科杂志2013，13，12： | 8 |
| 2 | Correlations of morphology and molecular alterations in traditional serrated adenoma显示文摘Traditional serrated adenoma was first reported by Longacre and FenoglioPresier in 1990.Their initial study described main features of this lesion,but the consensus diagnostic criteria were not widely adopted until recently.Traditional serrated adenoma presents with grossly protuberant configuration and pineconelike appearance upon endoscopy.Histologically,it is characterized by ectopic crypt formation,slit-like serration,eosinophilic cytoplasm and pencillate nuclei.Although much is now known about the morphology and molecular changes,the mechanisms underlying the morphological alterations are still not fully understood.Furthermore,the origin of traditional serrated adenoma is not completely known.We review recent studies of the traditional serrated adenoma and provide an overview on current understanding of this rare entity. | Hongxing Gui Michael A Husson Rifat Mannan | 2020 | World Journal of Gastrointestinal Pathophysiology2020，11，4： | 6 |
| 3 | 开窗畸形之基底动脉并发颅内多发性动脉瘤显示文摘 | 李文彬 李明华 H Grady Daniel Dee H Wu L.Tytle Rifat Karatas Yasemin Karatas William TC Yuh | 2003 | 实用放射学杂志2003，19，9： | 4 |
| 4 | Correlation of neutrophil/lymphocyte and platelet/lymphocyte ratio with visual acuity and macular thickness in age-related macular degeneration显示文摘AIM:To investigate the place of neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) in the diagnosis of and prognosis for neovascular age-related macular degeneration(AMD). METHODS:One hundred AMD patients and 100 healthy controls were included in the study. Blood samples were obtained from the venous blood, which is used for routine analysis, and these samples were subjected to complete blood count. NLR was defined as the neutrophil count divided by the number of lymphocytes, and PLR was defined as the platelet count divided by the number of lymphocytes. RESULTS:No statistically significant difference was observed between the two groups under consideration in terms of demographic features(P>0.05). The average NLR in the patient group was found to be significantly higher than that in the healthy control group(P<0.05). The average PLR was significantly higher in the patient group as compared to the control group(P<0.05). As best corrected visual acuity(BCVA) increased, both NLR and PLR decreased(significant negative correlations at 49.8% and 63.0%, respectively), whereas as central macular thickness(CMT) increased, both NLR and PLR increased(significant positive correlations at 59.3% and 70.0%, respectively).CONCLUSION:NLR and PLR levels are higher among neovascular AMD patients as compared to healthy control group. NLR and PLR levels were found to be inversely proportional to BCVA and directly proportional to CMT. | Elvan Alper Sengul Ozgur Artunay Alev Kockar Ceyda Afacan Rifat Rasier Palmet Gun Nazli Gul Yalcin Erdal Yuzbasioglu | 2017 | International Journal of Ophthalmology(English edition)2017，10，5： | 4 |
| 5 | 柔性接头地铁隧道穿越地裂缝的地震响应显示文摘采用振动台模型试验,模拟地震荷载和地裂缝场地沉降,分析了穿越地裂缝区域且设置柔性接头的分段地铁隧道的动力响应,研究了地裂缝场地沉降、裂缝发育特征、地铁隧道加速度响应特征、土压力与隧道各区段不同部位的应变规律。分析结果表明:由地裂缝场地沉降与地震荷载耦合作用所产生的差异沉降和裂缝多集中于柔性接头部位;各区段地铁隧道间的运动具有一定独立性,上盘靠近地裂缝的地铁隧道的加速度峰值是下盘隧道的3.2倍;距离地裂缝越近土压力越大,且在耦合荷载作用下,上盘土压力是下盘土压力的6.7倍;地铁隧道各区段左右拱腰应变较大,底板处应变次之,拱顶部位应变较小;柔性接头设置后各区段应变增率减小,在距离地裂缝较近部位未出现明显的应变增加现象。可见,在地震荷载与地裂缝场地沉降耦合作用下,柔性接头能够减小地铁隧道地裂缝位置处的集中应力与地裂缝场地的变形。 | 刘妮娜 刘军涛 黄强兵 韩冬冬 BULUT Rifat | 2015 | 交通运输工程学报2015，15，4： | 3 |
| 6 | Application of scoring systems with point-of-care ultrasonography for bedside diagnosis of appendicitis显示文摘BACKGROUND: Appendicitis is a common disease requiring surgery. Bedside ultrasound(BUS) is a core technique for emergency medicine(EM). The Alvarado score is a well-studied diagnostic tool for appendicitis. This study aimed to investigate the relationship between patients' symptoms, Alvarado score and ultrasound(US) findings, as performed by emergency physicians(EPs) and radiologists, of patients with suspected appendicitis.METHODS: Three EM specialists underwent the BUS course and core course for appendicitis assessment. Patients suspected of having appendicitis were selected and their Alvarado and modif ied(m) Alvarado scores calculated. The specialists performed the BUS. Then, patients were given a formal US and surgery consultation if necessary. Preliminary diagnoses, admission or discharge from the emergency department(ED) and fi nal diagnosis were documented. The patients were also followed up after discharge from the hospital.RESULTS: The determined cut-off value was 2 for Alvarado and 3 for m Alvarado scores. The sensitivities of the two scores were 100%. Each score was used to rule out appendicitis. The results of EP-performed BUS were as follows: accuracy 70%, sensitivity 0.733, specifi city 0.673, + LR 2.24, and – LR 0.40(95%CI). Radiologists were better than EPs at diagnosing appendicitis and radiologists and EPs were equally strong at ruling out appendicitis by US. When US was combined with Alvarado and m Alvarado scores, EP US+Alvarado/m Alvarado scores ≤3 and radiology US+Alvarado/m Alvarado scores ≤4 perfectly ruled out appendicitis.CONCLUSION: BUS performed by EPs is moderately useful in detecting appendicitis. Combined with scoring systems, BUS may be a perfect tool for ruling out decisions in EDs. | Erden Erol Unluer Rifat Urnal Utku Eser Serkan Bilgin Mehmet Haciyanh Orhan Oyar Haldun Akoglu Arif Karagoz | 2016 | World Journal of Emergency Medicine2016，7，2： | 2 |
| 7 | Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology显示文摘BACKGROUND The coronavirus disease 2019(COVID-19),a pandemic contributing to more than 105 million cases and more than 2.3 million deaths worldwide,was described to be frequently accompanied by extrapulmonary manifestations,including liver dysfunction.Liver dysfunction and elevated liver enzymes were observed in about 53%of COVID-19 patients.AIM To gain insight into transcriptional abnormalities in liver tissue of severe COVID-19 patients that may result in liver dysfunction.METHODS The transcriptome of liver autopsy samples from severe COVID-19 patients against those of non-COVID donors was analyzed.Differentially expressed genes were identified from normalized RNA-seq data and analyzed for the enrichment of functional clusters and pathways.The differentially expressed genes were then compared against the genetic signatures of liver diseases including cirrhosis,fibrosis,non-alcoholic fatty liver disease(NAFLD),and hepatitis A/B/C.Gene expression of some differentially expressed genes was assessed in the blood samples of severe COVID-19 patients with liver dysfunction using qRT-PCR.RESULTS Analysis of the differential transcriptome of the liver tissue of severe COVID-19 patients revealed a significant upregulation of transcripts implicated in tissue remodeling including G-coupled protein receptors family genes,DNAJB1,IGF2,EGFR,and HDGF.Concordantly,the differential transcriptome of severe COVID-19 liver tissues substantially overlapped with the disease signature of liver diseases characterized with pathological tissue remodeling(liver cirrhosis,Fibrosis,NAFLD,and hepatitis A/B/C).Moreover,we observed a significant suppression of transcripts implicated in metabolic pathways as well as mitochondrial function,including cytochrome P450 family members,ACAD11,CIDEB,GNMT,and GPAM.Consequently,drug and xenobiotics metabolism pathways are significantly suppressed suggesting a decrease in liver detoxification capacity.In correspondence with the RNA-seq data analysis,we observed a significant upregulation of DNAJB1 and HSP90AB1 as well as significant downregulation of CYP39A1 in the blood plasma of severe COVID-19 patients with liver dysfunction.CONCLUSION Severe COVID-19 patients appear to experience significant transcriptional shift that may ensue tissue remodeling,mitochondrial dysfunction and lower hepatic detoxification resulting in the clinically observed liver dysfunction. | Sarah Musa Hammoudeh Arabella Musa Hammoudeh Poorna Manasa Bhamidimarri Bassam Mahboub Rabih Halwani Qutayba Hamid Mohamed Rahmani Rifat Hamoudi | 2021 | World Journal of Gastroenterology2021，27，21： | 2 |
| 8 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 9 | Vapreotide labeled with Tc-99m for imaging tumors显示文摘 | Thakur M Kolan H Rifat S | 1996 | Int J Oncol1996，9，3： | 1 |
| 10 | Mood Disorder Following Crerbrovascular Accident显示文摘 | Eastwood M R Rifat S L Nobbs H | 1989 | Br J Psychiatry1989，154，： | 1 |
| 11 | High frequency of t(11;18) in gastric mucosa‐associated lymphoid tissue lymphomas in Taiwan, including one patient with high‐grade transformation显示文摘 | Shih‐SungChuang ChuanLee Rifat A.Hamoudi HongxiangLiu Po‐ShingLee HongtaoYe Tim C.Diss AhmetDogan Peter G.Isaacson Ming‐QingDu | 2002 | British Journal of Haematology2002，，1： | 1 |
| 12 | Concurrent rib and pelvic fractures as an indicator of solid abdominal organ injury显示文摘 | Ammar Al-Hassani Ibrahim Afifi Husham Abdelrahman Ayman El-Menyar Ammar Almadani Jan Recicar Hassan Al-Thani Kimball Maull Rifat Latifi | 2013 | International Journal of Surgery2013，，6： | 1 |
| 13 | Prostaglandin E receptor EP4 antagonism inhibits breast cancer metas'tasis显示文摘 | Ma X Kundu N Rifat S | 2006 | Cancer Res2006，66，6： | 1 |
| 14 | Contractor pre - qualification model : state - of - the - art 显示文摘 | NABIL E S DAVID E RIFAT R | 2007 | Interna- tional Journal of Project Management2007，25，5： | 1 |
| 15 | Risk factors for pulmonary tuberculosis in Russia: case-control study 显示文摘 | Richard Coker Martin McKee Rifat Atun | 2006 | BMJ2006，332，： | 1 |
| 16 | Antagonism of CXCR3 inhibitslung metastasis in a murine model of metastatic breast cancer 显示文摘 | Walser TC Rifat S Ma X | 2006 | Cancer Res2006，66，15： | 1 |
| 17 | Health care system frailties and public health control of communicable disease on the European Union Snew eastern border 显示文摘 | Richard J Coker Rifat AA tun Martin Me Kee | 2004 | The Lancet2004，163，24： | 1 |
| 18 | Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer 显示文摘 | Walser TC Rifat S Ma X | 2006 | Cancer Res2006，66，15： | 1 |
| 19 | Project Finance and the Private Finance Initiative 显示文摘 | Rifat A David E Andrew T | 2006 | Structured Finance2006，，： | 1 |
| 20 | Analysisof heat and mass transfer between a desieeant-air system in a packed tower显示文摘 | Gandhidasan P Rifat Ullah M Kettleborough C F | 1987 | Journal of Solar Energy Engineering1987，109，： | 1 |
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