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| 1 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 2 | Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury显示文摘 | Fatih Arslan Ruenn Chai Lai Mirjam B. Smeets Lars Akeroyd Andre Choo Eissa N.E. Aguor Leo Timmers Harold V. van Rijen Pieter A. Doevendans Gerard Pasterkamp Sai Kiang Lim Dominique P. de Kleijn | 2013 | Stem Cell Research2013，，3： | 2 |
| 3 | Passive ventricular remodeling in cardiac disease: focus on heterogeneity显示文摘 | KESSLER E L BOULAKSIL M VAN RIJEN H V | 2014 | Front Physiol2014，5，5： | 1 |
| 4 | 显示文摘 | van Veen AA van Rijen HV Opthof T | 2001 | Cardiol Res2001，51，2： | 1 |
| 5 | Cardiac gap junction channels: modulation of expression and channel properties显示文摘 | van Veen TAB van Rijen HVM Opthof T | 2001 | Circ Res2001，，51： | 1 |
| 6 | Physiology of cardiovas- cular gap junctions 显示文摘 | van Veen TA van Rijen HV Jongsma HJ | 2006 | Adv Cardio12006，42，： | 1 |
| 7 | Cardiac gap junction channels: modulation of expression and channel properties 显示文摘 | Van Veen AA van Rijen HV | 2001 | Cardiovasc Res2001，51，2： | 1 |
| 8 | Development of a functional magnetic resonance imaging protocol for intraoperative localization of critical temporoparietal language areas显示文摘 | Ruttan GJ Ramsey NF Van Rijen PC | 2002 | Ann Neurol2002，51，： | 1 |
| 9 | Human connexin40 gap junction channels are modulated by cAMP 显示文摘 | van Rijen HV van Veen TA Hermans MM | 2000 | Cantiovasc Res2000，45，4： | 1 |
| 10 | Cardiac gap junction channels : modulation of expression and channel properties 显示文摘 | van Veen AA van Rijen HV Opthot T | 2001 | Cardiovasc Res2001，51，2： | 1 |
| 11 | fMRI-determined language lateralization in patients with unilateral or mixed language dominance according to the Wada test 显示文摘 | Rutten GJM Ramsey NF van Rijen PC | 2002 | Neuroimage2002，17，： | 1 |
| 12 | Connexins and cardiac arrhythmias显示文摘 | VAN RIJEN H V VAN VEEN T A Gros D | 2006 | Adv Cardiol2006，42，： | 1 |
| 13 | Cardiac gap junction channels:modulation of expression and channel properties显示文摘 | VAN VEEN T VAN RIJEN H V OPTHOF T | 2001 | Cardiovasc Res2001，51，： | 1 |
| 14 | Medical predictors for psychopathology in adults with operated congenital heart disease显示文摘 | van Rijen EH Utens EM Roos-Hesselink JW | 2004 | Eur Heart J2004，25，： | 1 |
| 15 | Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43显示文摘 | van Rijen HV Eckardt D Degen J | 2004 | Circulation2004，109，： | 1 |
| 16 | Tumour necrosis factor alpha alters the expression of connexin43, connexin40, and connexin37 in human umbilical vein endothelial cells显示文摘 | van Rijen H V van Kempen M J Postma S | 1998 | Cytokine1998，10，4： | 1 |
| 17 | Remodeling of the cardiac sodium channel, connexin 43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy显示文摘 | Maartje Noorman Sara Hakim Elise Kessler Judith Groeneweg Moniek G.P.J. Cox Angeliki Asimaki Harold V.M. van Rijen Leonie van Stuijvenberg Halina Chkourko Marcel A.G. van der Heyden Marc A. Vos Nicolaas de Jonge Jasper J. van der Smagt Dennis Dooijes Arya | 2013 | Heart Rhythm2013，，： | 1 |
| 18 | Gap junctions in human umbilical cord endothe lial cells contain multiple connexins显示文摘 | Van Rijen HVM Van Kempen MJA Analbers LJS | 1997 | Am J Physiol1997，272，： | 1 |
| 19 | Connexins and cardiac arrhythmias显示文摘 | VAN RIJEN HV VAN、VEEN TA GROS D | 2006 | Adv Cardiol2006，42，： | 1 |
| 20 | Health-related quality of life and self-perceived competence of children assessed before and up to two years after epilepsy surgery显示文摘 | Van Empelen R Jennekens-Schinkel A Van Rijen PC | 2005 | Epilepsia2005，46，2： | 1 |
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