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| 1 | Perspectives on new biomarkers in gastric cancer: Diagnostic and prognostic applications显示文摘Gastric cancer is considered one of the most deadly tumors worldwide. Even with the decline in its incidence, the mortality rate of this disease has remained high, mainly due to its late diagnosis and to the lack of precise prognostic markers. The main purpose of this review is to present genetic, epigenetic and proteomic molecular markers that may be used in a diagnostic and prognostic manner and to discuss the pros and cons of each type of marker for improving clinical practice. In this sense, we observed that the use of genetic markers, especially mutations and polymorphisms, should be carefully considered, as they are strongly affected by ethnicity. Proteomic-based markers show promise, but the higher costs of the associated techniques con-tinue to make this approach expensive for routine use. Alternatively, epigenetic markers appear to be very promising, as they can be detected in bodily fluids as well as tissues. However, such markers must be used carefully because epigenetic changes may occur due to environmental factors and aging. Despite the advances in technology and its access, to date, there are few defined biomarkers of prognostic and diagnostic use for gastric tumors. Therefore, the use of a panel of several approaches(genetic, epigenetic and proteomic) should be considered the best alternative for clinical practice. | Danilo do Rosário Pinheiro Wallax Augusto Silva Ferreira Mariceli Baia Leo Barros Mariana Diniz Araújo Symara Rodrigues-Antunes Bárbara do Nascimento Borges | 2014 | World Journal of Gastroenterology2014，20，33： | 4 |
| 2 | In vitro toxicity of trichothecene on human erythroblastic progenitors 显示文摘 | Rio B Lautraite S and parent - Massin D | 1997 | Hum Exp Toxicol1997，16，： | 2 |
| 3 | The role of thrombopoietin in the thrombocytopenia of patients with liver cirrhosis显示文摘 | Rios R Sangro B Herrero I | 2005 | Am J Gastroenterol2005，100，： | 1 |
| 4 | Experimental analysis of the efficiency on charge/discharge cycles in natural gas storage by adsorption显示文摘 | Rios R B Bastos M Amora M R ct al | 2011 | Fuel2011，90，1： | 1 |
| 5 | Experimental analysis of the efficiency on charge/discharge cycles in natural gas storage by adsorption显示文摘 | Rios R B Bastos M Amora M R | 2011 | Fuel2011，90，1： | 1 |
| 6 | Separation of organic amine compounds on silica gel with reversed- phase eluents 显示文摘 | Bidlingmeyer B A Del Rios J K Korpi J | 1982 | Analytical Chemistry1982，54，： | 1 |
| 7 | Effects of High-Pressure Processing on the Quality of Sea Bass ( Dicentrarchus labrax ) Fillets During Refrigerated Storage显示文摘 | Bárbara Teixeira António Marques Rogério Mendes Amparo Gon?alves Liliana Fidalgo Marise Oliveira Jorge Alexandre Saraiva Maria Leonor Nunes | 2014 | Food and Bioprocess Technology2014，，5： | 1 |
| 8 | Specific expression of the pS2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone reeepters and the oncogene ERBB2显示文摘 | Rio MC Bellocq JP Gairard B | 1987 | Proc Natl Acad Sci USA1987，84，24： | 1 |
| 9 | Value of indirect hem agglutination and coagglutiation test for serotyping Haemophilus parasuis显示文摘 | Del Rio M L Gut ierrez B C Rodriguez Ferri E F | 2003 | Clin Microbio 12003，41，2： | 1 |
| 10 | The role of thrombopoietin in the thrombocytopenia of patients with liver cirrhosis显示文摘 | Rios R Sangro B Herrero I | 2005 | Am J Gastroenterol2005，100，6： | 1 |
| 11 | aroA gene PCR-RFLP diversity patterns in Haemophilus parasuis and Actinobacillus species显示文摘 | del Rio M L Martin C B Navas J | 2006 | Research in Veterinary Science2006，80，： | 1 |
| 12 | Ventilator-associated pneumonia due to colistin susceptible-only microorganisms显示文摘 | Rios FG Luna CM Maskin B | 2007 | Eur Respir J2007，30，2： | 1 |
| 13 | Methylprednisolone Effect on Brain Volume and Enhancing Lesions in MS Before and During IFN B-1 b显示文摘 | Rio A B Richer N Howard T B K | 2002 | Neurology2002，59，5： | 1 |
| 14 | Color change of fresh- cut apples coated with whey protein concentrate-based edible coatings 显示文摘 | PEREZ-GAGO M B SERRA M del RIO M A | 2006 | Postharvest Biology and Technology2006，39，1： | 1 |
| 15 | Value of fndirect hemagglutination and coagglutination tests for serotyping Haemophilus parasuis显示文摘 | Del Rio M L Gutierrez C B Rodriguez Ferri E F | 2003 | J Clin Microbiol2003，41，2： | 1 |
| 16 | Melatonin, an endogenous-specific inhibitor of estrogen receptor alpha via calmod- ulin显示文摘 | Del Rio B Garcia Pedrero JM Martinez Campa C | 2004 | J Biol Chem2004，279，38： | 1 |
| 17 | Recombinant human lacto- ferrin expressed in glycoengineered Pichia pastoris: effect of terminal N-acetylneuraminic acid on in vitro secondary humoral immune re- sponse 显示文摘 | CHOI B K ACTORJ K RIOS S | 2008 | Glycoconjugate journal2008，25，6： | 1 |
| 18 | Adsorption of phenylalanine on layered double hydroxides: Effect of temperature and ionic strength 显示文摘 | SILVéRIO F DOS REIS M J TRONTON J VLIM J B | 2008 | Journal Materials Science2008，43，： | 1 |
| 19 | Melatonin,an endogenous-specific inhibitor of estrogen receptor alpha viacalmodulin显示文摘 | Del Rio B Garcia Pedrero J M Martinez-Campa C | 2004 | J Biol Chem2004，279，38： | 1 |
| 20 | Value of indi- rect hemagglutination and coagglutination tests for serotyping Haemophilus parasuis 显示文摘 | Del Rio M L Gutierrez C B Rodriguez Ferri E F | 2003 | J Clin Microbiol2003，41，2： | 1 |
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