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| 1 | Pharmacognostic Identification of Yi Medicine Herba Boenninghauseniae Albiflorae显示文摘[Objectives] To identify original plant and traits of Yi medicine Herba Boenninghauseniae Albiflorae,and provide experimental data for its identification and application. [Methods] The original plant,traits,and microscopic identification were used. [Results] Essential identification characteristics of Yi medicine Herba Boenninghauseniae Albiflorae: small leaf was 1-2. 5 cm long,while the gynophore was 4-8mm long when bearing fruit; traits mainly included characteristic odor,strong and bitter taste,and spicy flavor; microscopic exclusive identifying characteristics: rich aleurone grain in the root; leaf had lysigenous secretory cavity,and non-glandular hairs and oil droplets were common. [Conclusions] Yi medicine Herba Boenninghauseniae Albiflorae( Ebazema) has distinctive identifying characteristics in original plant,traits,and microscopic tissues. This study is expected to provide certain reference for identification of original plant and medicine and formulation of quality standard for Yi medicine Ebazema,and to provide basis for its further research and development. | Ying LI Kaishun WANG Risha WEIZE Xuexue LI Yuan LIU Ayue AZI | 2017 | Medicinal Plant2017，8，3： | 3 |
| 2 | Principal component analysis of dissolution data with missing elements显示文摘 | Adams E Walczak B Vervaet C Risha P G Massart D L | 1997 | Chemometrics and intelligent aboratory systems1997，，32： | 2 |
| 3 | Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders:A review显示文摘Baicalin is a natural bioactive compound derived from Scutellaria baicalensis,which is extensively used in traditional Chinese medicine.A literature survey demonstrated the broad spectrum of health benefits of baicalin such as antioxidant,anticancer,anti-inflammatory,antimicrobial,cardio-protective,hepatoprotective,renal protective,and neuroprotective properties.Baicalin is hydrolyzed to its metabolite baicalein by the action of gut microbiota,which is further reconverted to baicalin via phase 2 metabolism in the liver.Many studies have suggested that baicalin exhibits therapeutic potential against several types of hepatic disorders including hepatic fibrosis,xenobiotic-induced liver injury,fatty liver disease,viral hepatitis,cholestasis,ulcerative colitis,hepatocellular and colorectal cancer.During in vitro and in vivo examinations,it has been observed that baicalin showed a protective role against liver and gut-associated abnormalities by modifying several signaling pathways such as nuclear factor-kappa B,transforming growth factor beta 1/SMAD3,sirtuin 1,p38/mitogen-activated protein kinase/Janus kinase,and calcium/calmodulin-dependent protein kinase kinaseβ/adenosine monophosphate-activated protein kinase/acetyl-coenzyme A carboxylase pathways.Furthermore,baicalin also regulates the expression of fibrotic genes such as smooth muscle actin,connective tissue growth factor,β-catenin,and inflammatory cytokines such as interferon gamma,interleukin-6(IL-6),tumor necrosis factor-alpha,and IL-1β,and attenuates the production of apoptotic proteins such as caspase-3,caspase-9 and B-cell lymphoma 2.However,due to its low solubility and poor bioavailability,widespread therapeutic applications of baicalin still remain a challenge.This review summarized the hepatic and gastrointestinal protective attributes of baicalin with an emphasis on the molecular mechanisms that regulate the interaction of baicalin with the gut microbiota. | Risha Ganguly Ashutosh Gupta Abhay K Pandey | 2022 | World Journal of Gastroenterology2022，28，26： | 2 |
| 4 | Baicalin provides protection against fluoxetine-induced hepatotoxicity by modulation of oxidative stress and inflammation显示文摘BACKGROUND Fluoxetine is one of the most widely prescribed anti-depressant drugs belonging to the category of selective serotonin reuptake inhibitors.Long-term fluoxetine treatment results in hepatotoxicity.Baicalin,a natural compound obtained from the Chinese herb Scutellaria baicalensis is known to have antioxidant,hepatoprotective and anti-inflammatory effects.However,the beneficial effects of baicalin against fluoxetine-induced hepatic damage have not previously been reported.AIM To evaluate the protective action of baicalin in fluoxetine-induced liver toxicity and inflammation.METHODS Male albino Wistar rats were divided into seven groups.Group 1 was the normal control.Oral fluoxetine was administered at 10 mg/kg body weight to groups 2,3,4 and 5.In addition,groups 3 and 4 were also co-administered oral baicalin(50 mg/kg and 100 mg/kg,respectively)while group 5 received silymarin(100 mg/kg),a standard hepatoprotective compound for comparison.Groups 6 and 7 were used as a positive control for baicalin(100 mg/kg)and silymarin(100 mg/kg),respectively.All treatments were carried out for 28 d.After sacrifice of the rats,biomarkers of oxidative stress[superoxide dismutase(SOD),catalase(CAT),reduced glutathione(GSH),glutathione-S-transferase(GST),advanced oxidation protein products(AOPP),malondialdehyde(MDA)],and liver injury[alanine transaminase(ALT),aspartate transaminase(AST),alkaline phosphatase(ALP),total protein,albumin,bilirubin]were studied in serum and tissue using standard protocols and diagnostic kits.Inflammatory markers[tumor necrosis factor(TNF-α),interleukin(IL)-6,IL-10 and interferon(IFN)-γ]in serum were evaluated using ELISA-based kits.The effect of baicalin on liver was also analyzed by histopathological examination of tissue sections.RESULTS Fluoxetine-treated rats showed elevated levels of the serum liver function markers(total bilirubin,ALT,AST,and ALP)and inflammatory markers(TNF-α,IL-6,IL-10 and IFN-γ),with a decline in total protein and albumin levels.Biochemical markers of oxidative stress such as SOD,CAT,GST,GSH,MDA and AOPP in the liver tissue homogenate were also altered indicating a surge in reactive oxygen species leading to oxidative damage.Histological examination of liver tissue also showed degeneration of hepatocytes.Concurrent administration of baicalin(50 and 100 mg/kg)restored the biomarkers of oxidative stress,inflammation and hepatic damage in serum as well as in liver tissues to near normal levels.CONCLUSION These findings suggested that long-term treatment with fluoxetine leads to oxidative stress via the formation of free radicals that consequently cause inflammation and liver damage.Concurrent treatment with baicalin alleviated fluoxetine-induced hepatotoxicity and liver injury by regulating oxidative stress and inflammation. | Risha Ganguly Ramesh Kumar Abhay K Pandey | 2022 | World Journal of Hepatology2022，14，4： | 1 |
| 5 | The effect of stoichiometry on the combustion behavior of a nanoscale Al/MoO3 thermite显示文摘 | Dutro G M Yetter R A Risha G A | | 0，，： | 1 |
| 6 | Combustion of bimodal nano/micron-sized aluminum particle dust in air 显示文摘 | Huang Ying Grant A Risha Vigor Yang | 2007 | Proceedings of the Combustion Institute2007，31，： | 1 |
| 7 | Effect of closed endotracheal tube suction method, catheter size, and post‐suction recruitment during high‐frequency jet ventilation in an animal model显示文摘 | J. Michele Hepponstall David G. Tingay Risha Bhatia Peter M. Loughnan Beverley Copnell | 2012 | Pediatr Pulmonol2012，，8： | 1 |
| 8 | Potential usage of energetic nano-sized powders for combustion and rocket propulsion显示文摘 | Kuo K K Risha G A EvansB J etal | 2004 | Materials Research Society Symposium Proceedings2004，，800： | 1 |
| 9 | Laser ignition characterization of N-5 double-base solid propellants 显示文摘 | Risha G A Kuo K K Koch D E | 2002 | Combustion of Energetic Material2002，，： | 1 |
| 10 | Accuracy profiles as- sessing the validity for routine use of high-performance thin-layer chromatographic assays for drug formulations显示文摘 | Shewiyo D H Kaale E Risha P G | 2013 | J Chromatogr A2013，1293，11： | 1 |
| 11 | Liquid ehroma-tographic-mass spectrometric assay for simul- taneous pyrimethamine and sulfa-doxine determination in human plasma samples显示文摘 | SINNAEVE BA DECAESTECKER TN RISHA PG | 2005 | J Chromatogr A2005，1076，12： | 1 |
| 12 | Metal particle combustion and nanotechnology 显示文摘 | Yetter R A Risha ( A Son S F | 2009 | Proc Combust Inst2009，32，2： | 1 |
| 13 | Metal particle combustion and nanotechnology显示文摘 | Yetter R A Risha G A Son S F | 2009 | Proceedings of the Combustion Institute2009，32，2： | 1 |
| 14 | Effect of reactant initial temperature on methane/oxygen diffusion flame stability in a furnace显示文摘 | Moore J D Risha G A Kuo K K | 2005 | Combustion Science and Technology2005，177，11： | 1 |
| 15 | Vapour of Acorus calamus oil-a space treatment for stored-product insects显示文摘 | EL-NAHAL A K M SCHMIDT G H RISHA E M | 1989 | Journal of Stored Products Research1989，25，： | 1 |
| 16 | Modulatory effect of caffeic acid in alleviating diabetes and associated complications显示文摘Diabetes mellitus(DM)is one of the most common metabolic disorders characterized by elevated blood glucose levels.Prolonged uncontrolled hyperglycemia often leads to multi-organ damage including diabetic neuropathy,nephropathy,retinopathy,cardiovascular disorders,and diabetic foot ulcers.Excess production of free radicals causing oxidative stress in tissues is often considered to be the primary cause of onset and progression of DM and associated complications.Natural polyphenols can be used to induce or inhibit the expression of antioxidant enzymes such as glutathione peroxidase,heme oxygenase-1,superoxide dismutase,and catalase that are essential in maintaining redox balance,and ameliorate oxidative stress.Caffeic acid(CA)is a polyphenolderived from hydroxycinnamic acid and possesses numerous physiological properties including antioxidant,anti-inflammatory,anti-atherosclerotic,immune-stimulatory,cardioprotective,antiproliferative,and hepatoprotective activities.CA acts as a regulatory compound affecting numerous biochemical pathways and multiple targets.These include various transcription factors such as nuclear factor-B,tumor necrosis factor-α,interleukin-6,cyclooxygenase-2,and nuclear factor erythroid 2-related factor 2.Therefore,this review summarizes the pharmacological properties,molecular mechanisms,and pharmacokinetic profile of CA in mitigating the adverse effects of DM and associated complications.The bioavailability,drug delivery,and clinical trials of CA have also been discussed. | Risha Ganguly Shiv Vardan Singh Kritika Jaiswal Ramesh Kumar Abhay K Pandey | 2023 | World Journal of Diabetes2023，14，2： | 1 |
| 17 | Effect of particle size on combustion of aluminum particle dust in air 显示文摘 | RISHA G A HUANG Y YETTER R A | 2009 | Combustion and flame2009，156，1： | 1 |
| 18 | Comprehensive Evaluation on Impacts of Diseases on Quality of Paris polyphylla var. chinensis Based on Ultraviolet and Infrared Spectra显示文摘[Objectives] The research aimed to evaluate impacts of diseases on quality of Paris polyphylla var. chinensis. [Methods]Ultraviolet spectrophotometry was used to determine and contrast content of total saponins in root,stem and leaf from healthy and diseased plants. Infrared characteristic absorption peaks of healthy and diseased plants were found by infrared fingerprint method for comparative analysis.[Results]Total saponins content in root sample J4 of healthy plant reached 4. 89% and was the highest,while it was 0. 13% in stem sample J11 of healthy plant and was the lowest. Total saponins content in root sample B1 of diseased plant was 1. 68% and was the highest,while it was 0. 1% in stem sample B7 of diseased plant and was the lowest. In healthy and diseased plants,total saponins content in root was significantly higher than that in stem and leaf. Content of total saponins in root from healthy plant was significantly higher than that from diseased plant,and there was little difference in stem and leaf of healthy and diseased plants. Root sample Jg of healthy plant had obvious C-O characteristic vibration of polysaccharides and glycosides and absorption peak of O-H bending vibration in steroidal saponin near 1 160. 02 cm-1,while diseased plant had no obvious absorption peak. Near 861. 97 and 768. 07 cm-1,root sample Jg of healthy plant had significant C-C stretching vibration in sugar ring and characteristic absorption peak of characteristic vibration of steroidal saponin,while root sample Bg of diseased plant had no obvious characteristic peak. [Conclusions] Diseases significantly affected composition and content of total saponins and steroidal saponins from P. polyphylla var. chinensis,further affecting quality of P. polyphylla var. chinensis. | Yongxia KE Jixiu SHEN Hairong ZHONG Risha WEIZE Yunzhang XU Yuan LIU | 2019 | Medicinal Plant2019，10，3： | 1 |
| 19 | Potential usage of energetic nano-sized powders for combustion and rocket propulsion显示文摘 | Kuo K K Risha G A Evans B J | 2004 | Materials Research Society Sym- posium Proceedings2004，800，： | 1 |
| 20 | The effect of aphasia upon personality traits, depression and anxiety among stroke patients 显示文摘 | Shehata GA El Mistikawi T Risha AS | 2014 | J Affect Disord2014，22，： | 1 |
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