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| 1 | Hepatitis B and C virus reactivation in immunosuppressed patients with inflammatory bowel disease显示文摘In recent years,a number of case reports and clinical studies have highlighted the risk of hepatitis B and C virus reactivation in patients with inflammatory bowel disease who are treated with immunosuppressive drugs.The cases of viral hepatitis reactivation that have been reported are characterized by a wide range of clinical manifestations,from viremia without clinically relevant manifestations to fulminant life-threatening hepatitis.The development and dissemination of biological immunosuppressive drugs have led to a significant increase in the number of reports of interest to physicians in a variety of clinical settings.On this topic,there have been a number of published guidelines and reviews that have collected the available evidence,providing recommendations on prophylactic and therapeutic strategies and methods for monitoring patients at risk.However,it should be noted that,to date,very few clinical studies have been published,and most of the recommendations have been borrowed from otherclinical settings.The published studies are mostly retrospective and are based on very heterogeneous populations,using different therapeutic and prophylactic regimens and obtaining conflicting results.Thus,it seems clear that it is desirable to concentrate our efforts on prospective studies,not conducting further reviews of the literature in the continued absence of new evidence. | Stefano Sansone Maria Guarino Fabiana Castiglione Antonio Rispo Francesco Auriemma Ilaria Loperto Matilde Rea Nicola Caporaso Filomena Morisco | 2014 | World Journal of Gastroenterology2014，20，13： | 6 |
| 2 | Fluoroquinolone-based protocols for eradication of Helicobacter pylori显示文摘Helicobacter pylori(H. pylori) is a widespread pathogen infecting about 40% of people living in urban areas and over 90% of people living in the developing regions of the world. H. pylori is well-documented as the main factor in the pathogenesis of peptic ulcer disease, chronic gastritis, and gastric malignancies such as cancer and mucosa-associated lymphoid tissuelymphoma; hence, its eradication is strongly recommended. the Maastricht Ⅳ consensus, which focused on the management of H. pylori infection, set important new strategies in terms of treatment approaches, particularly with regards to first- and second-line treatment protocols and led to improved knowledge and understanding of H. pylori resistance to antibiotics. In recent years, various fluoroquinolone-based protocols, mainly including levofloxacin, have been proposed and effectively tested at all therapeutic lines for H. pylori eradication. the aim of the present paper is to review the scientific literature focused on the use of fluoroquinolones in eradicating H. pylori. | Antonio Rispo Pietro Capone fabiana Castiglione Luigi Pasquale Matilde Rea Nicola Caporaso | 2014 | World Journal of Gastroenterology2014，20，27： | 3 |
| 3 | Fecal calprotectin in coeliac disease显示文摘We would like to share with the readers the results of our experience in 50 celiac disease(CD)patients,enrolled between September 2012 and April 2013,who were referred to our third-level CD Unit.The fecal calprotectin(FC)concentration of 50 adults with newly diagnosed CD was compared to that of a control group of 50 healthy subjects.FC level was determined by enzyme linked immunosorbent assay with diagnostic cutoff of 75μg/g.In addition,we tried to correlate the FC level with symptoms,histological severity of CD(Marsh grade)and level of tissue transglutaminase antibodies(aTg)in CD patients.Finally,FC level was increased in five CD patients and in four controls(10%vs 8%,P=NS);mean FC concentration of patients and controls were 57.7(SD±29.1)and 45.1(SD±38.4)respectively.Furthermore,no significant correlation was seen between FC levels and symptoms/Marsh grade/aTg.The five CD patients did not show inflammatory lesions(e.g.,ulcers,erosions)at upper endoscopy.The four healthy controls with positive FC were followed-up for further six months;in this observational period they did not show clinical signs of any underlying disease.On these bases,we think that FC is not able to investigate the subclinical inflammatory changes of active CD and FC should be considered a useless tool in the diagnostic work-up of uncomplicated CD but it should be accompanied by aTg when ruling out organic disease in patients with irritable bowel syndrome. | Pietro Capone Antonio Rispo Nicola Imperatore Nicola Caporaso Raffaella Tortora | 2014 | World Journal of Gastroenterology2014，20，2： | 3 |
| 4 | Orocecal transit time and bacterial overgrowth in patients with Crohn's disease显示文摘 | Castiglione F Del Vecchio Blanco G Rispo A | 2000 | J Clin Gastroenterol2000，31，1： | 1 |
| 5 | Increased risk of breast cancer in first-degree relatives of Crohn’s disease patients显示文摘 | G. Riegler L. Caserta F. Castiglione I. Esposito D. Valpiani V. Annese G. Zoli P. Gionchetti A. Viscido G.C. Sturniolo A. Rispo F.R. De Filippo A. de Leone R. Carratu | 2005 | Digestive and Liver Disease2005，，1： | 1 |
| 6 | Levofloxacin in first- line treatment of Helicobacter pylori infection 显示文摘 | Rispo A Di Girolamo E Cozzolino A | 2007 | Helicobacter2007，12，4： | 1 |
| 7 | levofloxacin in first-line treatment of helicobacter pylori infection显示文摘 | Rispo A Di Girolamo E Cozzolino A | 2007 | Helicobacter2007，12，4： | 1 |
| 8 | Antibiotic treatment of small bowel bacterial overgrowth in patients with Crohn's disease 显示文摘 | Castiglione F Rispo A Di Girolamo E | 2003 | Aliment Pharmacol Ther2003，18，1112： | 1 |
| 9 | Oroeecal transit time and bacterial overgrowth in patients with Croh n's disease显示文摘 | Castiglione F Del Vecechio Blanco G Rispo A | 2000 | J Clin Gastroenterol2000，31，1： | 1 |
| 10 | Effect of immunosuppressive therapy on patients with inflammatory bowel diseases and hepatitis B or C virus infection显示文摘 | F. Morisco F. Castiglione A. Rispo T. Stroffolini S. Sansone R. Vitale M. Guarino L. Biancone A. Caruso R. D’Inca R. Marmo A. Orlando G. Riegler L. Donnarumma S. Camera F. Zorzi S. Renna V. Bove G. Tontini M. Vecchi N. Caporaso | 2012 | J Viral Hepat2012，，3： | 1 |
| 11 | 在在病人诊断发育异常的共焦的激光 endomicroscopy 的诊断精确性由长期的 ulcerative 大肠炎影响了显示文摘 AIM:To evaluate the diagnostic accuracy of confocal laser endomicroscopy(CLE) for the detection of dysplasia in long-standing ulcerative colitis(UC).METHODS:We prospectively performed a surveillance colonoscopy in 51 patients affected by long-standing UC.Also,in the presence of macroscopic areas with suspected dysplasia,both targeted contrasted indigo carmine endoscopic assessment and probe-based CLE were performed.Colic mucosal biopsies and histology,utilised as the gold standard,were assessed randomly and on visible lesions,in accordance with current guidelines.RESULTS:Fourteen of the 51 patients(27%) showed macroscopic mucosal alterations with the suspected presence of dysplasia,needing chromoendoscopic and CLE evaluation.In 5 macroscopically suspected cases,the presence of dysplasia was confirmed by histology(3 flat dysplasia;2 DALMs).No dysplasia/cancer was found on any of the outstanding random biopsies.The diagnostic accuracy of CLE for the detection of dysplasia compared to standard histology was sensitivity 100%,specificity 90%,positive predictive value 83% and negative predictive value 100%.CONCLUSION:CLE is an accurate tool for the detection of dysplasia in long-standing UC and shows optimal values of sensitivity and negative predictivity.The scheduled combined application of chromoendoscopy and CLE could maximize the endoscopic diagnostic accuracy for diagnosis of dysplasia in UC patients,thus limiting the need for biopsies. | Antonio Rispo Fabiana Castiglione Stefania Staibano Dario Esposito Maria Siano Francesco Maione Francesca Salvatori Stefania Masone Marcello Persico Giovanni Domenico De Palma | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，9： | 1 |
| 12 | Levofloxacin in first- line treatment of Helicobacter pylori infection 显示文摘 | Rispo A Girolamo D E Cozzolino A | 2007 | Helicobacter2007，12，4： | 1 |
| 13 | Orocecal transittime and bacterial overgrowth in patients with Crohn’s disease 显示文摘 | Castiglione F Del Vecchio Blanco G Rispo A | 2000 | JClin Gastroenterol2000，31，1： | 1 |
| 14 | Orocecal Transit Time and Bacterial Overgrowth in Patients with Crohn’s Disease显示文摘 | Fabiana Castiglione Giovanna Del Vecchio Blanco Antonio Rispo Gino Petrelli Gaetano Amalfi Antonio Cozzolino Iolanda Cuccaro Gabriele Mazzacca | 2000 | Journal of Clinical Gastroenterology2000，，1： | 1 |
| 15 | Confocal laser endomicroscopy in inflammatory bowel diseases:Dream or reality?显示文摘Confocal laser endomicroscopy(CLE)is a newly introduced procedure that provide real-time,high-resolution imaging of the gastrointestinal mucosa during endoscopy,allowing the visualization of the pathology of the mucosal epithelium with its cellular and subcellular structures.Recently,the use of CLE was reported in the study of colonic mucosa in patients with inflammatory bowel diseases and in particular in patients affected by ulcerative colitis.CLE has the potential to have an important role in management of inflammatory bowel diseases(IBD)patients as it can be used to assess the grading of colitis and in detection of microscopic colitis in endoscopically silent segments.Moreover,CLE can be used in surveillance programs especially in highrisk patients.Finally,CLE has been effectively used in diagnosing a biliary dysplasia/neoplasia in patients with primary sclerosing cholangitis,a pathological condition frequently associated with IBD,with a coexisting bile duct stricture. | Giovanni Domenico De Palma Antonio Rispo | 2013 | World Journal of Gastroenterology2013，19，34： | 0 |
| 16 | Intestinal amyloidosis:Two cases with different patterns of clinical and imaging presentation显示文摘The involvement of the small bowel in systemic forms of amyloidosis may be diffuse or very rarely focal.Some cases of focal amyloidomas of the duodenum and jejunum without extraintestinal manifestations have been reported.The focal amyloidomas consisted of extensive amyloid infiltration of the entire intestinal wall thickness.Radiological barium studies,ultrasound and computed tomography(CT)patterns of diffuse small bowel amyloidosis have been described:the signs are non-specific and may include small-bowel dilatation,symmetric bowel wall thickening,mesenteric infiltration,and mesenteric adenopathy.No data are available about the positron emission tomography (PET)/CT and magnetic resonance imaging(MRI)patterns of intestinal amyloidosis.We report two cases of small bowel amyloidosis:the former characterized by focal deposition of amyloid proteins exclusively within blood vessel walls of the terminal ileum,the latter characterized by diffuse intestinal involvement observed on MRI and PET/CT studies. | Pier Paolo Mainenti Sabrina Segreto Marcello Mancini Antonio Rispo Immacolata Cozzolino Stefania Masone Ciro Roberto Rinaldi Gerardo Nardone Marco Salvatore | 2010 | World Journal of Gastroenterology2010，16，20： | 0 |
| 17 | High prevalence of post-partum depression in women with coeliac disease显示文摘AIM: To explore the prevalence of post-partumdepression(PPD) in coeliac disease(CD). METHODS: we performed a case-control study evaluating the prevalence of PPD in CD patients on gluten-free diet(GFD) compared to that of healthy subjects experiencing a recent delivery. All participants were interviewed about menstrual features, modality and outcome of delivery and were evaluated for PPD by Edinburgh Postnatal Depression Scale(EPDS). RESULTS: The study included 70 CD patients on GFD(group A) and 70 controls(group B). PPD was present in 47.1% of CD women and in 14.3% of controls(P < 0.01; OR = 3.3). Mean EPDS score was higher in CD compared to the controls(mean score: group A 9.9 ± 5.9; group B 6.7 ± 3.7; P < 0.01). A significant association was observed between PPD and menstrual disorders in CD(69.7% vs 18.9%; P < 0.001; OR = 3.6). CONCLUSION: PPD is frequent in CD women on GFD, particularly in those with previous menstrual disorders. we suggest screening for PPD in CD for early detection and treatment of this condition. | Raffaella Tortora Nicola Imperatore Carolina Ciacci Fabiana Zingone Pietro Capone Monica Siniscalchi Lucienne Pellegrini Giuliano De Stefano Nicola Caporaso Antonio Rispo | 2015 | World Journal of Obstetrics and Gynecology2015，4，1： | 0 |
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