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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Accuracy of biometric formulae for intraocular lens power calculation in a teaching hospital显示文摘AIM: To evaluate the accuracy of three commonly used biometric formulae across different axial lengths(ALs) at one United States Veterans Affairs teaching hospital.METHODS: A retrospective chart review was conducted from November 2013 to May 2018. One eye of each patient who underwent cataract surgery with a monofocal intraocular lens(IOL) was included. The range of postoperative follow-up period was from 3 wk to 4 mo. The Holladay 2, Barrett Universal II, and Hill-Radial Basis Function(Hill-RBF) formulae were used to predict the postoperative refraction for all cataract surgeries. For each formula, we calculated the prediction errors [including mean absolute prediction error(MAE)] and the percentage of eyes within ±0.25 diopter(D) and ±0.5 D of predicted refraction. We performed subgroup analyses for short(AL<22.0 mm), medium(AL 22.0-25.0 mm), and long eyes(AL>25.0 mm).RESULTS: A total of 1131 patients were screened, and 909 met the inclusion criteria. Resident ophthalmologists were the primary surgeons in 710(78.1%) cases. We found no statistically significant difference in predictive accuracy among the three formulae over the entire AL range or in the short, medium, and long eye subgroups. Across the entire AL range, the Hill-RBF formula resulted in the lowest MAE(0.384 D) and the highest percentage of eyes with postoperative refraction within ±0.25 D(42.7%) and ±0.5 D(75.5%) of predicted. All three formulae had the highest MAEs(>0.5 D) and lowest percentage within ±0.5 D of predicted refraction(<55%) in short eyes.CONCLUSION: In cataract surgery patients at our teaching hospital, three commonly used biometric formulae demonstrate similar refractive accuracy across all ALs. Short eyes pose the greatest challenge to predicting postoperative refractive error. | Kevin S Tang Elaine M Tran Allison J Chen David R Rivera Jorge J Rivera Paul B Greenberg | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 3 |
| 3 | Application of games with incomplete information for pricing electricity in deregulated power pools显示文摘 | Fenrero R W Rivera J F | 1998 | IEEE Trans on Power Systems1998，13，1： | 2 |
| 4 | Application of games with incomplete information for pricing electricity in deregulated power pools显示文摘 | Ferrero R W Rivera J F Shahidehpour S M | 1998 | IEEE Trans on Power Systems1998，13，1： | 2 |
| 5 | Novel process for low temperature crystallization of a-SiC: H for optoelectronic applications显示文摘 | Hossain M Perez J R S Rivera J M R | 2009 | Journal of Materials Science2009，20，： | 1 |
| 6 | Thermodynamic analysis of monomethylamine-water solutions in a single-stage solar absorption refrigeration cycle at low generator temperatures 显示文摘 | Pilatowsky I Rivera W Romero R J | 2001 | Solar Energy Mater Solar Cells2001，70，： | 1 |
| 7 | Platinum based chemotherapy plus cetuximab in head and neck cancer 显示文摘 | Vermorken J B Mesia R Rivera F | 2008 | N Engl J Med2008，359，11： | 1 |
| 8 | Platinum-based chemotherapy plus Cetuximab in head and neck Caneer显示文摘 | Vermorken J Mesia R Rivera F | 2008 | N Engl J Med2008，359，11： | 1 |
| 9 | Novel process for low temperature crystallization of α-SIC: H for optoelectronic applications显示文摘 | Hossain M Perez J R S Rivera J M R | 2009 | Journal of Materials Science2009，20，1： | 1 |
| 10 | A simple adjustable window algorithm to improve FFT measurements显示文摘 | Hidalgo R M Fernandez J G Rivera R R | 2002 | IEEE Transactions on Instrumentation and Measurement2002，51，1： | 1 |
| 11 | Biological assessment of aspirin efficacy on healthy individuals: heterogeneous response or aspirin failure 显示文摘 | Gonzalez-Conejero R Rivera J Corral J | 2005 | Stroke2005，36，： | 1 |
| 12 | Shape Optimization for Tool Wear in the Friction-stir Welding of Cast Al359-20%SiCMMC显示文摘 | A R Rivera L E Murr | 2002 | Journal of Materials Science2002，37，10： | 1 |
| 13 | Biological assessment of aspirin efficacy on healthy individuals: heterogeneous response or aspirin failure? 显示文摘 | Gonzalez-Conejero R Rivera J Corral J | 2005 | Stroke2005，36，2： | 1 |
| 14 | Observation of ferrotoroidic domains 显示文摘 | Van Aken B B Rivera J R Schmid H | 2007 | Nature2007，449，： | 1 |
| 15 | On the time polynomial decay in elastic solids with voids显示文摘 | Mu(n)oz Rivera J E Quintanilla R | | 0，，： | 1 |
| 16 | AmeriCan college of chest physicians,guidelines on treatment of stage Ⅲ B non-small cell Lung cancer显示文摘 | JETT J R SCOOT W J RIVERA M P | 2003 | Chest2003，123，1： | 1 |
| 17 | Three-dimensional echocardiography improves non-invasive assessment of left ventricular volume and performance显示文摘 | SIU S C LEVINE R A RIVERA J M | 1995 | Am Heart J1995，130，7： | 1 |
| 18 | Salicylic acid-derived poly (anhydride- ester) electrospun fibers designed for regenerating the peripheral nervous system显示文摘 | Griffin J Delgado- Rivera R Meiners S | 2011 | J Biomed Mater Res A2011，97，： | 1 |
| 19 | Stabilization in elastic solids with voids显示文摘 | Pamplona P X Mu(n)oz Rivera J E Quintanilla R | | 0，，： | 1 |
| 20 | Rapid detection of Clostridmatrices, and buffer using paramagnetic bead-based elecltrochemiluminescence detection 显示文摘 | RIVERA V R GAMEZ F J KEENER W K | 2006 | Anal Biochem2006，353，2： | 1 |
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