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| 1 | Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice显示文摘AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes. | Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera Gabriela A Martín | 2009 | World Journal of Gastroenterology2009，15，9： | 3 |
| 2 | Clinical significance of'anti-HBc alone'in human immunodeficiency virus-positive patients显示文摘AIM:To determine the prevalence and clinical relevance of isolated antibodies to hepatitis B core antigen as the only marker of infection('anti-HBc alone')among human immunodeficiency virus(HIV) type-1 infected patients.Occult hepatitis B infection frequency was also evaluated. METHODS:Three hundred and forty eight histories from 2388 HIV-positive patients were randomly reviewed.Patients with serological markers of hepatitis B virus(HBV)infection were classified into three groups:past hepatitis,'anti-HBc alone'and chronic hepatitis.Determination of DNA from HBV,and RNA and genotype from hepatitis C virus(HCV)were performed on'anti-HBc alone'patients. RESULTS:One hundred and eighty seven(53.7%) HIV-positive patients had markers of HBV infection: 118 past infection(63.1%),14 chronic hepatitis (7.5%)and 55'anti-HBc alone'(29.4%).Younger age[2.3-fold higher per every 10 years younger;95% confidence intervals(CI)1.33-4.00]and antibodies to HCV infection[odds ratio(OR)2.87;95%CI 1.10-7.48]were factors independently associated with the'anti-HBc alone'pattern.No differences in liver disease frequency were detected between both groups. Serum levels of anti-HBs were not associated with HCV infection(nor viral replication or HCV genotype),or with HIV replication or CD4 level.No'anti-HBc alone' patient tested positive for HBV DNA. CONCLUSION:'Anti-HBc alone'prevalence in HIVpositive patients was similar to previously reported data and was associated with a younger age and with antibodies to HCV infection.In clinical practice,HBV DNA determination should be performed only in those patients with clinical or analytical signs of liver injury. | M~aTeresa Pérez-Rodríguez Bernardo Sopea Manuel Crespo Alberto Rivera Teresa González del Blanco Antonio Ocampo César Martínez-Vázquez | 2009 | World Journal of Gastroenterology2009，15，10： | 2 |
| 3 | 2-Week triple therapy for Helicobacter pylori infection is better than 1-week in clinical Practice: a large prospective single-center randomized st udy显示文摘 | Paoluzi P Iacopini F Crispino P Nardi F Bella A Rivera M Rossi P Gurnari M Caracciolo F Zippi M Pica R | 2006 | Helicobacter2006，11，： | 1 |
| 4 | Neo-clerodane diterpenoids and other constituents from Baccharis species 显示文摘 | Faini F Rivera P Mah M | 1987 | Phytochemistry1987，26，： | 1 |
| 5 | Thermal integration of heat pumping systems in distillation columns 显示文摘 | P Rivera - Ortega M picon - Nunez E Tortes - reyes A Gallegos - Munoz | 1999 | Applied Thermal Engi- neering1999，19，81： | 1 |
| 6 | Role of the ouabain- like factor and Na-K pump in rat and human genetic hyper- tension显示文摘 | Ferrandi M Manunta P Rivera R | 1998 | Clin Exp Hypertens1998，20，56： | 1 |
| 7 | A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA binding activity显示文摘 | Rivera V M Miranti C K Misra R P | 1993 | Mol Cell Biol1993，13，10： | 1 |
| 8 | Monitoring photooxidation of the Prestige's oil spill by attenuated total reflectance infrared spectroscopy 显示文摘 | Varela R F Carracedo M P G Rivera P F | 2006 | Talanta2006，69，： | 1 |
| 9 | AmeriCan college of chest physicians,guidelines on treatment of stage Ⅲ B non-small cell Lung cancer显示文摘 | JETT J R SCOOT W J RIVERA M P | 2003 | Chest2003，123，1： | 1 |
| 10 | Predictive control of an indirect matrix converter显示文摘 | Correa P Rodriguez J Rivera M | 2009 | IEEE Transactions on Industrial Electronics2009，56，6： | 1 |
| 11 | Overexpression of GATA-2 inhibits erythroid and promotes megakaryocyte differentiation 显示文摘 | Ikonomi P Rivera CE Riordan M | 2000 | Experimental Hematology2000，28，12： | 1 |
| 12 | Effect of short-term freeze-thaw cycling on composite confined concrete 显示文摘 | Karbhari V M Rivera J Dutta P K | 2000 | Journal of Composite for Construction2000，4，4： | 1 |
| 13 | Minimally invasive esophagectomy:outcomes in 222 patients显示文摘 | LUKETICH J D ALVELO RIVERA M BUENAVENTURA P O | 2003 | Ann Surg2003，238，4： | 1 |
| 14 | Predictive an indirect matrix converter显示文摘 | Correa P control of Rodriguez J Rivera M | 2009 | IEEE Transactions on Industrial Electronics2009，56，6： | 1 |
| 15 | Predictive control of an indirect matrix converter显示文摘 | Correa P Rodriguez J Rivera M | 2009 | IEEETransactions on Industrial Electronics2009，56，6： | 1 |
| 16 | Psychosocial factors associatedwith orthodontic and orthognathic surgical treatment 显示文摘 | Rivera S M Hatch J P Rugh J D | 2000 | Seminars inOrthodontics2000，6，4： | 1 |
| 17 | Solid-phase extraction for the selective isolation of polycyclic aromatic hydrocar- bons, azaarenes and heterocyclic aromatic amines in char- coal-grilled meat显示文摘 | Rivera L Curto M J C Pais P | 1996 | J Chromatogr A1996，731，12： | 1 |
| 18 | Rho kinase activation and gene expression related to vascular remodeling in normotensive rats with high angiotensin I converting enzyme levels显示文摘 | Rivera P Ocaranza M P Lavandero S | 2007 | Hypertension2007，50，4： | 1 |
| 19 | The effect of soy oligosaccharide extraction on diet digestibility, faecal characteris- tics, and intestinal gas production in dogs显示文摘 | FeLix A P Rivera N L M Sabehuk T T | 2013 | Animal Feed Sci- ence & Technology2013，184，14： | 1 |
| 20 | Development of a fast analytical tool to identify oil spillages employing infrared spectral indexes and pattern recognition techniques显示文摘 | RIVERA P F VARELA R F CARRACEDO M P | 2007 | Talanta2007，74，： | 1 |
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