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112篇 您的检索式:作者名="Rizzo I"
    题名 作者 年代 出处 被引量
1Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma.Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero 2007World Journal of Gastroenterology2007,13,44:4
2Role Conflict and Ambiguity in Complex Organizations显示文摘John R Rizzo Robert J House and Sidney I Lirtzman 1970Administrative Science Quarterly1970,15,02:1
3Embryonic soluble HLA-G as a marker of developmental potential in embryos显示文摘Noei I Fuzzi B Rizzo R 2005Hum Reprod2005,20,1:1
4HLA-G may predict the disease course in patients'with early rheumatoid arthritis显示文摘Rizzo R Farina I Bortolotti D 2013Hum Immunol2013,74,4:1
5Role conflict and ambiguity in complex organizations 显示文摘Rizzo J R House R J Lirtzman S I 1970Admin- istrative Science Quarterly1970,15,2:1
6Role Conflict and Ambiguity in Complex Organizations 显示文摘Rizzo J R House R J Lirlzmon S I 1970Administrative Science Quarterly1970,15,:1
7A framework for sign language sentence recognition by commonsense context 显示文摘lnfantino I Rizzo R Gaglio S 2007IEEE Transactions on Systems Man and Cybernetics: C2007,37,5:1
8Role Conflict and Ambiguity in Complex Organizations 显示文摘RIZZO J R HOUSE R J LIRTZMAN S I 1970Administrative Science Quarterly1970,15,2:1
9Role Conflict and Ambiguity in Complex Organizations显示文摘Rizzo J R House R J Lirtzman S I 1970Ad- ministrative Science Quarterly1970,15,2:1
10Embryonic soluble HLA-G as a marker of developmental potential in embryos 显示文摘Noci I Fuzzi B Rizzo R 2005Hum Reprod2005,20,1:1
11Left-sided appendicitis: diagnosis and minimally invasive treatment显示文摘Fernandez EM Favre Rizzo J Arteaga Gonz61ez I 2014Acta Gastroenterol Latinoam2014,44,1:1
12Safe lumbar punctureunder analgo-sedation in children with acute lymphoblasticleukemia 显示文摘MAURIZI P RUSSO I RIZZO D 2014Int J Clin Oncol2014,19,1:1
13Association of elevated fibrinogen and C-reactive protein levels with carotid lesions in patients with newly diagnosed hypertension or type ll diabetes显示文摘Corrado E Rizzo M Muratori I 2006Arch Med Res2006,37,8:1
14Assessment of toxigenic fungi on Argentinean medicinal herbs 显示文摘Rizzo I Vedoya G Maurutto S 2004Microbiology Re- search2004,159,2:1
15Role conflict and ambiguity in complex organizations显示文摘Rizzo J R House R J Lirtzman S I 1970Ad- ministrative science quarterly1970,,:1
16Embryonic soluble HLA-G as a marker of developmental potential in embryos显示文摘Noci I Fuzzi B Rizzo R 2005Hum Reprod2005,20,1:1
17Embryonic soluble HLA-G as a marker of developmental potential in embryos 显示文摘Noci I Fuzzi B Rizzo R 2005Hum Reprod2005,20,1:1
18High incidence of TIMI flow 0 to I in patients with ST- elevation myocardial infarction without eletrocardiographic lyric criteria 显示文摘Figuers J Ferreira - Gonzalez I Rizzo M 2009Am Heart J2009,158,:1
19Embryonic soluble HLA-G as a marker of developmental potential in embryos显示文摘Noci I Fuzzi B Rizzo R 2005Hum Reprod2005,20,:1
20Urban wastewater treatment plants as hotspots for the release of antibiotics in the environment:A review显示文摘MICHAEL I RIZZO L MCARDELL C S 2013Water research2013,47,3:1
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