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| 1 | Prognostic values of tumor endothelial markers in patients with colorectal cancer显示文摘AIM: Tumor endothelial markers (TEMs) are a newly discovered family of endothelial markers associated with tumor specificangiogenesis. This study sought to examine the levels of expression (qualitatively and quantitatively)for TEMs in human colon cancer.METHODS: Human colorectal cancer tissues (n = 48)and normal background tissues (n = 31) were obtained after surgery. RNA was extracted from frozen sections for gene amplification. The expression of TEMs (TEM-1to TEM-8) was assessed using RT-PCR and their transcript levels were determined using real-time-quantitative PCR(Q-RT-PCR).RESULTS: TEM-1 (P = 0.01), TEM-7 (P = 0.04), TEM-7R(P= 0.03), TEM-8 (P = 0.001) significantly raised in colon cancer tissues compared with the levels detected in normal background tissues. The expressions of TEM-2 and TEM-6were found to be not significantly different between tumor tissues and normal tissues (P>0.05). Patients who had cancer penetrating into and through the muscularis propria of the bowel wall and developed nodal involvement(Dukes C) exhibited significantly higher levels of TEM -8compared to patients who were node negative (P<0.05).TEM-7 and TEM-7R showed high level of transcripts in Dukes C, but they were not statistically significant.CONCLUSION: The level of the expression of TEM-1,TEM-7, TEM-7R and TEM-8 (but not TEM-2 and TEM-6)were associated with both nodal involvement and disease progression, and may therefore, have a prognostic value in colorectal cancer. | KA Rmali MCA Puntis WG Jiang | 2005 | World Journal of Gastroenterology2005，11，9： | 7 |
| 2 | Tumour-associated angiogenesis in human colorectal cancer显示文摘 | Rmali KA Puntis MC Jiang WG | 2007 | Colorectal Dis2007，9，1： | 1 |
| 3 | Tumou-associated angiogenesis in human colorectalr显示文摘 | Rmali KA Puntis MC Jiang WC | 2007 | Colorectal Dis2007，9，1： | 1 |
| 4 | Tumour-associated angiogenesis in human colorectal cancer显示文摘 | Rmali KA Puntis MC Jiang WG | 2007 | Colorectal Dis2007，9，1： | 1 |
| 5 | Tumour associated angiogenesis in human coloreet cancer 显示文摘 | Rmali KA Puntis MC Jiang WG | 2007 | Colorectal Dis2007，9，1： | 1 |
| 6 | Tumor-associated angiogenesis in human colorectal cancer显示文摘 | Rmali KA Puntis MC Jiang WG | 2007 | Colorectal Dis2007，9，1： | 1 |
| 7 | Tumour - associatedangiogenesis in human colorectal cancer 显示文摘 | Rmali KA Puntis MC Jiang WG | 2007 | Colorectal Dis2007，9，1： | 1 |
| 8 | Tumour-associated angiogenesis in human colorectal cancer 显示文摘 | Rmali KA Puntis MC Jiang WC | 2007 | Colorectal Dis2007，9，1： | 1 |
| 9 | Elevated levels of tumour endothelial marker-8 in human breast cancer and its clinical signifieance显示文摘 | Davies G Rmali KA Watkins G | 2006 | Int J Oneol2006，29，5： | 1 |
| 10 | Tumour-associated angiogenesis in human colorectal cancer显示文摘 | Rmali KA Puntis MC Jiang WG | 2007 | Colorectal Dis2007，9，1： | 1 |
| 11 | TEM-8 and tubule formation inendothelial cells, its potential role of its vW/TM domains 显示文摘 | Rmali KA Puntis MC Jiang WG | 2005 | BiochemBiophys Res Commun2005，334，： | 1 |
| 12 | TEM-8 and tubule formation in endothelial cells, its potential role of its vW/TM domains显示文摘 | Rmali KA Puntis MC Jiang WG | 2005 | Biochem Biophys Res Commun2005，334，1： | 1 |
| 13 | TEM-8 and tubule formation in endothelial cells, its potential role of its vW/TM domains 显示文摘 | Rmali KA Puntis MC Jiang WG | 2005 | Biochem Biophys Res Commun2005，334，： | 1 |
| 14 | Angiopoietins lack of prognostic significance in ductal mammary carcinoma显示文摘 | Rmali KA Watkins G Douglas -Jones A | 2007 | Int Serain Sur Oncol2007，23，2： | 1 |
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