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| 1 | Bone metastases:When and how lung cancer interacts with bone显示文摘Bone metastasis is a common and debilitating consequence of lung cancer:30%-40% of patients with nonsmall cell lung cancer develop bone metastases during the course of their disease. Lung cancer cells find a favorable soil in the bone microenvironment due to factors released by the bone matrix, the immune system cells, and the same cancer cells. Many aspects of the cross-talk among lung tumor cells, the immune system,and bone cells are not clear, but this review aims to summarize the recent findings in this field, with particular attention to studies conducted to identify biomarkers for early detection of lung cancer bone metastases. | Ilaria Roato | 2014 | World Journal of Clinical Oncology2014，5，2： | 14 |
| 2 | Gastric cancer:The times they are a-changin'显示文摘Gastric cancer is the third leading cause of cancer death worldwide.Even though during these last decades gastric cancer incidence decreased in Western countries,it remains endemic and with a high incidence in Eastern countries.The survival in advanced and metastatic stage of gastric cancer is still very poor.Recently the Cancer Genoma Atlas Research Network identified four subtypes with different molecular profiles to classify gastric cancer in order to offer the optimal targeted therapies for pre-selected patients.Indeed,the key point is still the selection of patients for the right treatment,on basis of molecular tumor characterization.Since chemotherapy reached a plateau of efficacy for gastric cancer,the combination between cytotoxic therapy and biological agents gets a better prognosis and decreases chemotherapeutic toxicity.Currently,Trastuzumab in combination with platinum and fluorouracil is the only approved targeted therapy in the first line for c-erb B2 positive patients,whereas Ramucirumab is the only approved targeted agent for patients with metastatic gastric cancer.New perspectives for an effective treatment derived from the immunotherapeutic strategies.Here,we report an overview on gastric cancer treatments,with particular attention to recent advances in targeted therapies and in immunotherapeutic approach. | Maria Antonietta Satolli Lucio Buffoni Rosella Spadi Ilaria Roato | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 6 |
| 3 | A mouse model of pulmonary metastasis from spontaneous osteosarcoma monitored in vivo by lnciferase imaging显示文摘 | Miretti S Roato I Taulli R | 2008 | PLOS ONE2008，3，3： | 1 |
| 4 | Osteoclastogenesis in peripheral blood mononuclear cell cultures of periprosthetic osteolysis patients and the phenotype of T cells localized in periprosthetic tissues显示文摘 | Roato I Caldo D D\'Amico L | 2010 | Biomaterials2010，31，29： | 1 |
| 5 | Bone and bone manw pro- osteoclastogenic cytokines are up - regulated in osteoporosis fragility fractures 显示文摘 | DAmelio P Roato I DAmieo L | 2011 | Osteoporos Int2011，11，： | 1 |
| 6 | Expression pattern of receptor activator of NFκB(RANK)in a series of primary solid tumors and related bone metastases显示文摘 | Santini D Perrone G Roato I | 2011 | J Cell Physiol2011，226，3： | 1 |
| 7 | Spontaneous osteoclastogenesis is apredictivefactor for bonemetastases from non-smallcelllungcancer显示文摘 | Roato I Gorassini E Buffoni L | | 0，，01： | 1 |
| 8 | DKK-1 in prostate cancer diagnosis and follow up显示文摘 | D'Amelio P Roato I Oderda M | 2014 | BMC Clin Pathol2014，14，1： | 1 |
| 9 | Osteoclastogenesis in peripheral blood mono-nuclear cell cultures of periprosthetic osteolysis patients and the phenoltype of T cells localized in periprosthetic tissues显示文摘 | Roato I Caldo D D'Amico L | 2010 | Biomaterials2010，29，： | 1 |
| 10 | Expression pattern of receptor activator of NFκB(RANK)in a series of primary solid tumors and related bone metastases显示文摘 | Santini D Perrone G Roato I | | 0，，03： | 1 |
| 11 | 显示文摘 | Cignetti A Vallario A Roato I | 2004 | J Immunol2004，173，4： | 1 |
| 12 | Osteoclastogenesis in peripheral blood mononuclear cell cultures of periprosthetic osteolysis patients and the phenotype of T cells localized in periprosthetic tissues显示文摘 | Roato I Caldo D D'Amico L | | 0，，29： | 1 |
| 13 | Osteoclastogenesis in peripheral blood mononuclear cell cultures of periprosthetic osteolysis patients and the phenotype of T cells localized in periprosthetic tissues显示文摘 | Roato I Caldo D D’Amico L | 2010 | Biomaterials2010，31，29： | 1 |
| 14 | A mouse model of pulmonary metastasis from spontaneous osteosarcoma monitored in vivo by luciferase imaging显示文摘 | Miretti S Roato I Taulli R | | 0，，03： | 1 |
| 15 | Mechanisms of spontaneous osteoclastogenesis in cancer with bone involvement显示文摘 | ROATO I GRANO M BRUNETTI G | 2005 | FASEB J2005，19，2： | 1 |
| 16 | Leukemia-derived immature dendritic cells differentiate into functionally competent mature dendritic cells that efficiently stimulate T cell responses显示文摘 | Cignetti A Vallario A Roato I | 2004 | J Immunol2004，173，4： | 1 |
| 17 | Leukemia- derived immature dendritic cells differentiate into functionally competent mature dendritic cells that efficiently stimulate T -cell responses 显示文摘 | Cignetti A Vallario A Roato I | 2004 | J Immunol2004，173，4： | 1 |
| 18 | Bone impairment in phenylketonuria is characterized by circulating osteoclast precursors and activated T cell increase 显示文摘 | Roato I Porta F Mussa A | 2010 | PLoS One2010，5，14： | 1 |
| 19 | Leukemia-derived immature dendritic cells differentiate into functionally competent mature dendritic cells that efficiently stimulate T cell responses 显示文摘 | CIGNETTI A VALLARIO A ROATO I | 2004 | J Immunol2004，173，4： | 1 |
| 20 | Expression pattern of receptor activator of NFkappaB(RANK) in a series of primary solid tumors and related bone metastases 显示文摘 | Santini D Perrone G Roato I | 2011 | J Cell Physiol2011，226，3： | 1 |
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