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1篇 您的检索式：作者名="Rob ME Slangen"

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		题名	作者	年代	出处	被引量
	1	Diarrhoea in a patient with metastatic melanoma:Ipilimumab ileocolitis treated with infliximab显示文摘Administration of ipilimumab,a cytotoxic T-lymphocyte associated antigen-4-blocking monoclonal antibody,leads to enhancement of the anti-tumor T-cell respons and as a result shows a significant survival benefit in metastatic melanoma patients.Therefore patients are currently receiving this promising therapy as a secondline strategy.Unfortunately,by activation of the T-cell immune reponse,ipilimumab therapy may lead to an unwanted induction of different autoimmune phenomena.Diarrhoea and colitis occur in up to one third of patients.Here we present a case of ipilimumab induced ileocolitis which was successfully treated with infliximab,an anti-tumor necrosis factor monoclonal antibody,after corticosteroid therapy failure.Although formal trials are lacking,recently publicated series suggest that infusional therapy of infliximab is effective in ipilimumab induced ileocolitis.	Rob ME Slangen Alfonsus JM van den Eertwegh Adriaan A van Bodegraven Nanne KH de Boer	2013	World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，3：	0

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