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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | Perceived improvements in nitrogen fertilizer efficiency from cotton precision farming 显示文摘 | Torbett J C Roberts R K Larson J A | 2008 | Computers and Electronics in Agriculture2008，64，2： | 1 |
| 4 | Synthesis and properties of waterborne self-crosslinkable sulfo-urethane silanol dispersions 显示文摘 | Kevin Lewandowski Larry R Krepski Daniel E Mickus Ralph R Roberts Steven M Heilmann Wayne K Larson Mark D Purgett Steven D Koecher Stephen A Johnson Daniel J Mcgurran Chris J Rueb Sadanand V Pathre Khalid A M Thakur | 2002 | Journal of Polymer Science Part A : Polymer Chemistry2002，40，17： | 1 |
| 5 | Perceived improvements in nitrogen fertilizer efficiency from cotton precision farming 显示文摘 | Torbett J C Roberts R K Larson J A | 2008 | Computers and Electronics in Agriculture2008，64，2： | 1 |
| 6 | Switchgrass Yield Response Functions and Profit-Maximizing Nitrogen Rates on Four Landscapes in Tennessee显示文摘 | Boyer Christopher N Tyler Donald D Roberts Roland K English Burton C Larson James A | 2012 | Agronomy Journal2012，，6： | 1 |
| 7 | Perceived improvements in nitrogen fertilizer efficiency from cotton precision farming显示文摘 | Torbett J C Roberts R K Larson J A | 2008 | Computers and Electronics in Agriculture2008，64，2： | 1 |
| 8 | The Academic Community's Par- ticipation in Global Accounting Standard-setting显示文摘 | Robert K Larson Paul J Herz | 2011 | Research in Accounting Regulation2011，23，： | 1 |
| 9 | Risk factors for candidemia in critically ill infants: a matched case-control study显示文摘 | Feja KN Wu F Roberts K Loughrey M Nesin M Larson E | 2005 | J Pediatr2005，147，2： | 1 |
| 10 | The Harmonization of International Accounting Standards:Progress in the 1990s?显示文摘 | Larson Robert K Sara York Kenny | 1999 | Multinational Business Review1999，7，1： | 1 |
| 11 | Effects of plant population density on net revenues from ultra-narrow-row cotton显示文摘 | LARSON J A Gwathmey C O Roberts R K | 2004 | The Journal of Cotton Science2004，，8： | 1 |
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