|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | De novo malignancies after liver transplantation: The effect of immunosuppression-personal data and review of literature显示文摘BACKGROUND Immunosuppression has undoubtedly raised the overall positive outcomes in the post-operative management of solid organ transplantation. However, long-term exposure to immunosuppression is associated with critical systemic morbidities. De novo malignancies following orthotopic liver transplants (OLTs) are a serious threat in pediatric and adult transplant individuals. Data from different experiences were reported and compared to assess the connection between immunosuppression and de novo malignancies in liver transplant patients. AIM To study the role of immunosuppression on the incidence of de novo malignancies in liver transplant recipients. METHODS A systematic literature examination about de novo malignancies and immunosuppression weaning in adult and pediatric OLT recipients was described in the present review. Worldwide data were collected from highly qualified institutions performing OLTs. Patient follow-up, immunosuppression discontinuation and incidence of de novo malignancies were reported. Likewise, the review assesses the differences in adult and pediatric recipients by describing the adopted immunosuppression regimens and the different type of diagnosed solid and blood malignancy.RESULTS Emerging evidence suggests that the liver is an immunologically privileged organ able to support immunosuppression discontinuation in carefully selected recipients. Malignancies are often detected in liver transplant patients undergoing daily immunosuppression regimens. Post-transplant lymphoproliferative diseases and skin tumors are the most detected de novo malignancies in the pediatric and adult OLT population, respectively. To date, immunosuppression withdrawal has been achieved in up to 40% and 60% of well-selected adult and pediatric recipients, respectively. In both populations, a clear benefit of immunosuppression weaning protocols on de novo malignancies is difficult to ascertain because data have not been specified in most of the clinical experiences. CONCLUSION The selected populations of tolerant pediatric and adult liver transplant recipients greatly benefit from immunosuppression weaning. There is still no strong clinical evidence on the usefulness of immunosuppression withdrawal in OLT recipients on malignancies. An interesting focus is represented by the complete reconstitution of the immunological pathways that could help in decreasing the incidence of de novo malignancies and may also help in treating liver transplant patients suffering from cancer. | Tommaso Maria Manzia Roberta Angelico Carlo Gazia Ilaria Lenci Martina Milana Oludamilola T Ademoyero Domiziana Pedini Luca Toti Marco Spada Giuseppe Tisone Leonardo Baiocchi | 2019 | World Journal of Gastroenterology2019，25，35： | 3 |
| 2 | Clinical and histological characteristics of papillary thyroid micmcarcinoma:Results of a retrospective study in 243 patients显示文摘 | Elio R Roberta K Giorgio T | | 0，，06： | 1 |
| 3 | Classi- fication of Brazilian honeys by physical and chemical analyti- cal methods and low field nuclear magnetic resonance (LFIH NMR) 显示文摘 | Roberta de O R R Eliane T M Carla da S C | 2014 | LWT- Food Science and Technology2014，55，： | 1 |
| 4 | Evolution of bank ef- ficiency in Brazil: A DEA approach 显示文摘 | Roberta B S Geraldo S S Benjamin M T | 2010 | European Journal of Opera- tional Research2010，202，1： | 1 |
| 5 | Structural evaluation of sugar cane bagasse steam pretreated in the presence of CO2 and SO2显示文摘 | Roberta Cristina Novaes Reis Corrales Fabiana Magalhles T Mendes Clarissa C Perrone | 2012 | Biotechnology for Biofuels2012，5，1： | 1 |
| 6 | Classification of Brazilian honeys by physical and chemical analytical methods and low field nuclear magnetic resonance(LF 1 H NMR)显示文摘 | RIBEIRO ROBERTA D O R ELIANE T C | 2014 | LWT-Food Science and Technology2014，55，： | 1 |
| 7 | Synchronous primary neoplasms of the female reproductive tract显示文摘 | ROBIN F E ROBERTA K N JONATHAN T B | 1989 | Gynecologic Oncology1989，33，3： | 1 |
| 8 | Hepatitis B and C virus infection, alcohol drinking, hepatocellular carcinoma: a case control study in Italy显示文摘 | Farucesco D Alessandro T Roberta C | 1997 | Hapatology1997，26，3： | 1 |
| 9 | erecta 显示文摘 | Roberta Piccaglia Mauro Marotti Siliva Grandi Lutein and lutein ester content in different types of Tagetes patula and T | 1998 | Industrial crops and products1998，，8： | 1 |
| 10 | Physical and enzymatic properties of lignin peroxidase isoenzymes from Phanerochaete chrysosporium显示文摘 | ROBERTA L F KAREN E M MING T | 1989 | Enzyme Microb Technol1989，11，6： | 1 |
| 11 | Treatment options in recurrent cervical cancer:Review显示文摘 | Angiolo G Roberta T Stefania C | 2010 | Oncol Lett2010，1，1： | 1 |
| 12 | Relationship be- tween the Nanosmtures and the Optical Properties of CeO2 Thin Films显示文摘 | Roberta G T Graziella M Fragala I L | 2004 | Journal of Physical Chemistry2004，108，16： | 1 |
| 13 | Development of sarcomas in mice implanted with mesenchymal stem cells seeded onto bioscaffolds显示文摘 | Roberta T Andrea A Michela C | 2009 | Carcinogenesis2009，，： | 1 |
| 14 | Clinical and histological characteristics of papillary thyroid microcarcinoma: results of a retrospectivestudy in 243 patients显示文摘 | Elio R Roberta R Giorgio T | 2006 | J Clin Endocrinol Metab2006，91，6： | 1 |
| 15 | A peach linkage map integration RFLPs, SSRs, RAPDs, and morphological markers 显示文摘 | MARIA T D ROBERTA Q IGNAZIO V | 2001 | Genome Ottawa2001，44，： | 1 |
| 16 | Recruitment of a Host's Osteoprogenitor Cells Using Exogenous Mesenchymal Stem Cells Seeded on Porous Ceramic显示文摘 | Roberta T Andrea A Simona B | 2009 | Tissue Eng Part A2009，15，8： | 1 |
| 17 | Detection of residual/ recurrent cervical disease after successful LEEP conization: the possible role of mRNA-HPV test显示文摘 | Roberta Z Manuel MI Andrea T | 2013 | Curr Pharm Des2013，19，8： | 1 |
| 18 | Implementing the 2005 American Heart Association Guidelines,Including Use of the Impedance Threshold Device, Improves Hospital Discharge Rate After In-Hospital Cardiac Arrest 显示文摘 | Ken T Scott PD Roberta B | 2010 | Respiratory Care2010，55，8： | 1 |
| 19 | A peach linkage map intergrating RFLPs,SSRs, RAPDs, and morphological markers 显示文摘 | Maria T D Roberta Q Ignazio V | 2001 | Genome2001，44，： | 1 |
| 20 | Dergulation of apoptiosis in acute myeloid lcukemia显示文摘 | Ugo T Roberta R | 2007 | Haematologica2007，92，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员