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1篇 您的检索式:作者名="Roberto Gambarini"
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1Insight into the effects of electrochemical factors on host-guest interaction induced signature events in a biological nanopore显示文摘The signature events caused by host-guest interactions in the nanopore system can be used as a novel and characteristic signal in quantitative detection and analysis of various molecules.However,the effect of several electrochemical factors on the host-guest interactions in nanopore still remains unknown.Here,we systematically studied host-guest interactions,especially oscillation of DNA-azide adamantane@cucurbit[6]inα-Hemolysin nanopore under varying pH,concentration of electrolytes and counterions(Li+,Na+,K+).Our results indicate correlations between the change of pH and the duration of the oscillation signal.In addition,the asymmetric electrolyte concentration and the charge of the counterions affects the frequency of signature events in oscillation signals,and even the integrity of the protein nanopore.This study provides insight into the design of a future biosensing platform based on signature oscillation signals of the host-guest interaction within a nanopore.XiaojunWei Zehui Zhang XiaoqinWang Brian Lenhart Roberto Gambarini Jonathan Gray Chang Liu 2020Nanotechnology and Precision Engineering2020,3,1:1
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