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| 1 | High-flow nasal oxygen availability for sedation decreases the use of general anesthesia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasound显示文摘AIM To examine whether high-flow nasal oxygen(HFNO) availability influences the use of general anesthesia(GA) in patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) and endoscopic ultrasound(EUS) and associated outcomes.METHODS In this retrospective study, patients were stratified into 3 eras between October 1, 2013 and June 30, 2014 based on HFNO availability for deep sedation at the time of their endoscopy. During the first and last 3-mo eras(era 1 and 3), no HFNO was available, whereas it was an option during the second 3-mo era(era 2). The primary outcome was the percent utilization of GA vs deep sedation in each period. Secondary outcomes included oxygen saturation nadir during sedation between periods, as well as procedure duration, and anesthesia-only time between periods and for GA vs sedation cases respectively.RESULTS During the study period 238 ERCP or EUS cases were identified for analysis. Statistical testing was employed and a P < 0.050 was significant unless the Bonferroni correction for multiple comparisons was used. General anesthesia use was significantly lower in era 2 compared to era 1 with the same trend between era 2 and 3(P = 0.012 and 0.045 respectively). The oxygen saturation nadir during sedation was significantly higher in era 2 compared to era 3(P < 0.001) but not between eras 1 and 2(P = 0.028) or 1 and 3(P = 0.069). The procedure time within each era was significantly longer under GA compared to deep sedation(P ≤ 0.007) as was the anesthesia-only time(P ≤ 0.001).CONCLUSION High-flow nasal oxygen availability was associated with decreased GA utilization and improved oxygenation for ERCP and EUS during sedation. | Roman Schumann Nikola S Natov Klifford A Rocuts-Martinez Matthew D Finkelman Tom V Phan Sanjay R Hegde Robert M Knapp | 2016 | World Journal of Gastroenterology2016，22，47： | 9 |
| 2 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 3 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 4 | Excluding infection through procalcitonin testing improves outcomes of congestive heart failure patients presenting with acute respiratory symptoms: Results from the randomized ProHOSP trial显示文摘 | Philipp Schuetz Alexander Kutz Eva Grolimund Sebastian Haubitz Désirée Demann Alaadin V?geli Fabienne Hitz Mirjam Christ-Crain Robert Thomann Claudine Falconnier Claus Hoess Christoph Henzen Robert J. Marlowe Werner Zimmerli Beat Mueller | 2014 | International Journal of Cardiology2014，，3： | 2 |
| 5 | Hyper-X Post-Flight Trajectory Reconstruction显示文摘 | Christopher D K Paul V T Robert C B | 2006 | Journal of Spacecraft and Rockets2006，43，1： | 1 |
| 6 | Coupled thermo-mechanical waves in hyperbolic thermoelasticity显示文摘 | STRUNIN D V MELNIK R V N ROBERTS A J | 2001 | Journal of Thermal Stresses2001，24，： | 1 |
| 7 | Comparison between the reactivity of commercial and synthetic TiO2 photocatalysts显示文摘 | PISCOPO A ROBERT D WEBER J V | 2002 | Journal of Photochem and Photobio A:Chemistry2002，139，： | 1 |
| 8 | Reduction of post-thoracotomy pain by cryotherapy of intercostal nerves显示文摘 | Roberts D Pizzarelli G Lepore V | 1988 | Scand J Thorac Cardiovasc Surg1988，22，2： | 1 |
| 9 | Land cover mapping at sub-pixel scales using linear optimization techniques显示文摘 | Jan V Robert D W | 2002 | Remote Sensing of Environment2002，，79： | 1 |
| 10 | Comparision between the reactivity of commercial and synthetic TiO2 photocatalysts显示文摘 | PISCOPO A ROBERT D WEBER J V | 2001 | Journal of Photochemistry and Photobiology A: Chemistry2001，139，2： | 1 |
| 11 | XML-based mobile agents显示文摘 | ROBERT S THARAM D PARTH P YURI V | 2005 | IEEE Computer Society Proceedings of the International Conference on Information Technology:Coding and Computing (ITCC''05)2005，11，： | 1 |
| 12 | Synthesis and ant-HIV activity of 1,1 '-dideoxygossypol and related compounds显示文摘 | ROBERT E R LORRAINE M D JAGT V | 1995 | J Med Chem1995，38，13： | 1 |
| 13 | The induction in vitro of adventitious shoots in Rosa显示文摘 | LLOYD D ROBERTS A V SHORT K C | 1988 | Euphytica1988，37，： | 1 |
| 14 | How strong is the association between maternal thrombophilia and adverse pregnancy outcome? A systematic review显示文摘 | Alfirevic Z Roberts D Martlew V | 2002 | Eur J Obstet Gynecol Reprod Biol2002，101，1： | 1 |
| 15 | Influence of pH and chloride anion on the photocatalytic degradation of organic compounds 显示文摘 | Piscopo A Robert D Weber J V | 2001 | Applied Catalysis B: Environmental2001，35，： | 1 |
| 16 | Estimates of the elasticities of substitution between imports and home goods for the United States显示文摘 | Clinton R S Robert M S Alan V D | | 0，，03： | 1 |
| 17 | Malignant ascites protect against TRAIL-induced apoptosis by activating the P13K/Akt pathway in human ovarian carcinoma cells 显示文摘 | Lane D Robert V Gmdin R | 2007 | Int J Cancer2007，121，6： | 1 |
| 18 | Structure and energetics of ligand binding to proteins: Escherichia coli dihydrofolate reductase- trimethoprim, a drug-receptor system 显示文摘 | DAUBER O P ROBERTS V A OSGUTHORPE D J | 1998 | Proteins: Structure Function and Genetics1998，4，1： | 1 |
| 19 | Low dielectric cons- tantmaterials 显示文摘 | WILLI V ROBERT D M GERAUD D | 2010 | Chemical Reviews2010，110，1： | 1 |
| 20 | Comparison between the reactivity of commercial and synthetic TiO2 photocatalysts显示文摘 | PISCOPO A ROBERT D WEBER J V | 2001 | Journal of Photochemistry and Photobiology A : Chemistry2001，，139： | 1 |
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