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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Fibrinogen induces endothelial cell permeability显示文摘 | Tyagi N Roberts AM Dean WL | 2008 | Mol Cell Biochem2008，307，12： | 1 |
| 3 | Effects of hemoglobin C and S traits on glycohemoglobin measurements by eleven methods显示文摘 | Roberts WL Safar-Pour S De Bk | 2005 | Clin Chem2005，51，4： | 1 |
| 4 | Evaluation of nine automated high-sensitivity C-reactive protein methods: implications for clinical and epidemiological applications 显示文摘 | Roberts WL Moulton L Law TC | 2001 | Part 2 Clinical Chemistry2001，47，： | 1 |
| 5 | Trends in intTavenous iron use among dialysis patients in the United States( 1994 -2002) 显示文摘 | St Peter WL Obrador GT Robert TL | 2005 | Am J Kidney Dis2005，46，4： | 1 |
| 6 | Evaluation offour automated high-sensitivity C-reactive protein methods: implications for clinical and epidemiological applications显示文摘 | Roberts WL Sedrick R Moulton L | 2000 | Clin Chem2000，46，4： | 1 |
| 7 | Evaluation of nine auto- mated high sensitivity C-reactive protein methods implications for clinical and epidemiological applications显示文摘 | Roberts Wl Moulton L Law TC | 2001 | Clin Chem2001，47，3： | 1 |
| 8 | Effects of hemoglobin C and S traits on glyhemoglobin measurements by eleven methods 显示文摘 | Roberts WL Safar-Pour S De BK | 2005 | Clin Chem2005，51，4： | 1 |
| 9 | Effect of mutant IkappaB on cytokine-induced activation of NF-KappaB in cultured human RPE cells显示文摘 | Yang P McKay BS Allen JB Roberts WL Jaffe GJ | 2003 | Invest Ophthalmol Vis Sci2003，44，3： | 1 |
| 10 | Evaluation of four automated high-sensitivity C-reactive protein methods:implication for clinical and epidemiological application显示文摘 | Roberts WL Sedrick R Moulton | 2002 | Clin Chem2002，46，： | 1 |
| 11 | NFK-KDOQI Guidelines: National kidney foundation-kidney disease outcomes quality initiative 显示文摘 | Collins A J Roberts TL St Peter WL | 2002 | Am J Kidney Dis2002，39，： | 1 |
| 12 | AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: laboratory tests available to assess inflammation-performance and standardization: a back ground paper显示文摘 | Roberts WL CDC AHA CDC | 2004 | irculation2004，，25： | 1 |
| 13 | Evaluationofnineauto-m atedhigh-sensitivity C-reactiveproteinmethods:implicationsf orclinicalandepidemiologicalapplications显示文摘 | Roberts WL Moulton L Law TC | 2001 | Clin Chem2001，47，3： | 1 |
| 14 | Performance characteristics of six Third-generation Assay for thyroid-stimulating hormone显示文摘 | Rawlins ML Roberts WL | 2004 | Clin Chem2004，50，12： | 1 |
| 15 | Metabolite and matrix interference in phenytoin immunoassays 显示文摘 | Rainey PM Rogers KE Roberts WL | 1996 | Clinical Chemistry1996，42，10： | 1 |
| 16 | Evalution of nine automated high C-reactive protein methods:implications for clinical and epidemiological applications显示文摘 | Roberts WL Moulton L Law TC | 2001 | Clin Chem2001，47，5： | 1 |
| 17 | Effects of hemoglobin C and S traits on glycohemoglobin measurements by eleven methods显示文摘 | Roberts WL Safaar-Pour S De BK | 2005 | Clin Chem2005，51，： | 1 |
| 18 | Markers of apoptosis in Cardio vascular tissues显示文摘 | Van Heerde WL Robert -offerman S Dumont E | 2000 | Cardiovasc -Res2000，45，3： | 1 |
| 19 | Evaluation of four auto- mated high - sensitivity C - reactive protein methods: implications for clinical and epidemiological applications 显示文摘 | Roberts WL Sedrick R Moulton L | 2000 | Clin Chem2000，46，4： | 1 |
| 20 | Evaluation of nine automated high sensitivity C-reactive protein methods:implications for clinical and epidemiological applications显示文摘 | Roberts WL Moulton L Law TC | 2001 | Clin Chem2001，47，： | 1 |
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