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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Probiotic potential of Mi-nas fresh cheese prepared with the addition of Lactobacillus paracasei显示文摘 | Buriti F A da Rocha J S Assis E G | | 0，，02： | 1 |
| 3 | Probiotic potential of Minas fresh cheese prepared with the addition of Lactobacillus paracasei 显示文摘 | BURITI F C A DA ROCHA J S ASSIS E G | 2005 | Lebensmittel-Wissenschaft und Tehonlogie2005，38，2： | 1 |
| 4 | Replication of the tumor necrosis factor receptor-associated factor 1/complement component 5 region as a susceptibility locus for rheumatoid arthritis in a European family-based study显示文摘 | Kurreeman F A S Rocha D Houwing-Duistermaat J | 2008 | Arthritis &Rheumatism2008，58，9： | 1 |
| 5 | Effect of solids on homogeneous-heterogeneous flow regime transition in bubble cohimns 显示文摘 | Mena P C Ruzicka M C Rocha F A | 2005 | Chemical Engineering Science2005，60，22： | 1 |
| 6 | Differentially expressed angiogenic genes in diabetic erectile tissue-results from a microarray screening显示文摘 | CASTELA A SOARES R ROCHA F | 2012 | Mol Genet Metab2012，105，2： | 1 |
| 7 | Lipase immobilization onto polymeric membrance 显示文摘 | CARNERIRO-da-CUNDA M C ROCHA J M S GARCIA F A P | 1979 | Biotechnol Techniques1979，13，： | 1 |
| 8 | Wet depositionand related atmospheric chemistry in the S(a)o Paulo Metropolis,Brazil:Part 1-Major inorganic ions in rainwater as evaluated by capillary electrophoresis with contactless conductivity detection显示文摘 | F R Rocha S Fracassi A José | 2003 | Atmos Environ2003，37，： | 1 |
| 9 | Isomerization of α-pinene oxide over cerium and tin catalysts: Selective synthesis of trans-carveol and trans-sobrerol显示文摘 | COSTA V V ROCHA K A SOUSA L F | 2011 | Journal of Molecular Catalysis A: Chemical2011，345，12： | 1 |
| 10 | Hydroxyapatite nano-powders produced hydrothermally from nacreous material显示文摘 | Lemos A F Rocha J H G Quaresma S S F | 2006 | Journal of the European Ceramic Society2006，26，16： | 1 |
| 11 | Widely linear adaptive equalization of digital communication channel 显示文摘 | de Aquino F J A Resende L S da Rocha C A F | 2010 | IEEE Latin America Transactions2010，8，1： | 1 |
| 12 | Lactate detection by MRS in mitochondrial encephalopathy: optimi- zation of technical parameters显示文摘 | Jos6 da Rocha A Ttllio Braga F Carlos Martins Maia A Jr | 2008 | J Neuroimaging2008，18，： | 1 |
| 13 | Reduction of blood nitric oxide levels is associated with clinical improvement of the chronic pelvic pain related to endometriosis显示文摘 | Rocha M G Gomes V A Tanus-Santos J E Rosa-E-Silva J C Candido-Dos-Reis F J Nogueira A A | 2015 | Braz J Med Biol Res2015，48，： | 1 |
| 14 | Luminesc-ent multifunctional lanthanides-based metal-organic frameworks显示文摘 | Rocha J Carlos L D Paz F A A | 2011 | Chem Soc Rev2011，40，2： | 1 |
| 15 | Toxicity of some glucose/mannose-binding lectins to Biomphalaria glabrata and Artemia salina显示文摘 | SANTOS A F D CAVADA B S ROCHA B A M D | 2010 | Bioresource Technology2010，101，2： | 1 |
| 16 | Fuzzy-set based models of neurons and knowledge-based networks显示文摘 | Pedrycz W Rocha A F | 1993 | IEEE Trans on Fuzzy Systems1993，1，4： | 1 |
| 17 | Posterior 'superior mesenteric artery first' approach for resection of locally advanced pancreatic cancer 显示文摘 | Rose JB Rocha F Alseidi A | 2014 | Ann Surg Oncol2014，21，6： | 1 |
| 18 | Morphological and mechanical properties of hybrid matrices of polysiloxanepolyvinyl alcohol prepared by sol-gel technique and their potential for immobilizing enzyme 显示文摘 | Santos J C Paula A V Rocha C G F | 2008 | J Non-Cryst Solids2008，354，： | 1 |
| 19 | Hydro-xyapatite nano-powders produced hydrothermally from nacreous material显示文摘 | Lemos A F Rocha J H G Ferreira J M F | 2006 | Journal of the European Ceramic Society2006，26，16： | 1 |
| 20 | Experimental study of the impacts of planktivorous fishes on planktn community and eutrophication of a tropical Brazilian reservoir显示文摘 | Starling F Rocha A J A | 1990 | Hydrobiologia1990，，： | 1 |
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