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您的检索式：作者名="Roderick T Bronson"
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| 1 | Fine Mapping of a Deafness Mutation hml on Mouse Chromosome 10显示文摘Objective To map a mouse deafness gene, identify the underlying mutation and develop a mouse model for human deafness. Methods Genetic linkage cross and genome scan were used to map a novel mutation named hypoplasia of the membranous labyrinth (hml), which causes hearing loss in mutant mice. Results ① hml was mapped on mouse Chr 10 (~43 cM from the centromere) suggests that the homologous human gene is on 12q22-q24, which was defined on the basis of known mouse-human homologies (OMIM, 2004). ② This study has generated 25 polymorphic microsatellite markers, placed 3 known human genes in the correct order in a high-resolution mouse map and narrowed the hml candidate gene region to a 500 kb area. | Belinda S Harris Patricia F Ward-Bailey Roderick T Bronson Muriel T Davisson Kenneth R Johnson | 2004 | Journal of Pharmaceutical Analysis2004，16，1： | 0 |
| 2 | 小鼠10号染色体上致聋突变基因hml的精确定位(英文)显示文摘目的 定位小鼠致聋基因 ,识别决定其性状的有关突变 ,为人类耳聋基因研究提供动物模型。方法 利用全基因组扫描来定位名为hml可致小鼠听力丧失突变基因。结果 ①hml基因定位在小鼠 10号染色体上 ,距中心粒约4 3cM处。根据已知的鼠 人同源同线性特点 ,提示人的同源基因位于 12 q2 2 -q2 4 ;②获得了 2 5个多态性微卫星标记 ,通过高分辨的小鼠图谱将 3个已知人类基因进行了正确排列 ,并将hml侯选基因限定在一个 5 0 0kb的区域内。 | Belinda S Harris Patricia F Ward-Bailey Heping Yu Roderick T Bronson Muriel T Davisson Kenneth R Johnson | 2004 | 西安交通大学学报(医学版)2004，25，3： | 0 |
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