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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Effect of Low-level Laser ( Ga-AlAs 655 nm) on Skeletal Muscle Fatigue Induced by Electrical Stimulation in Rats 显示文摘 | ALVARO R B LOPES-MARTINS RODRIGO L M | 2006 | J Appl Physiol2006，101，7： | 1 |
| 3 | Characterization of en- tomopathogenie nematodes and symbiotic baeteria active against Spodoptera frugiperda ( Lepidoptera : Noctuidae ) and contribution of bacterial urease to the insecticidal effect 显示文摘 | Juliana M S Marina S D Rodrigo L B | 2012 | Biological Control2012，63，： | 1 |
| 4 | Microstructure and wear resistance of Al-SiC composites coatings on ZE41 magnesium alloy显示文摘 | RODRIGO P CAMPO M TORRES B | 2009 | Applied Surface Science2009，255，22： | 1 |
| 5 | Detection of Ellipses Using Modified Hough Transform 显示文摘 | Patricia M B MANSO Rodrigo F PRESTES and Mariane R PETRAGLIA | 2003 | IEEE International Symposium2003，，2： | 1 |
| 6 | Adaptive granular local search heuristic for a dynamic vehicle routing problem显示文摘 | Rodrigo M B Vinícius A A | 2009 | Computers&Operations Research2009，36，11： | 1 |
| 7 | Regulation of carotenoid biosynthesis during fruit maturation in the red-fleshed orange mutant Cara Cara显示文摘 | ALQU(E)ZAR B RODRIGO M J ZACAR~AS L | | 0，，10： | 1 |
| 8 | Object-oriented modeling for the transient performance simulation of parabolic trough collec- tors using molten salt as heat transfer fluid 显示文摘 | Fritz Z Rodrigo M Javier G B | 2013 | Solar Energy2013，95，： | 1 |
| 9 | Retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic hematopoietic stem cell transplantation using HLA-identical sibling donors in myelodysplastic syndromes 显示文摘 | Rodrigo M Simona I Ronald B | 2006 | Blood2006，108，： | 1 |
| 10 | Adaptive granular local search heuristic for a dynamic vehicle routing problem显示文摘 | Rodrigo M B Vinicius A A | 2009 | Computers and Operations Research2009，36，11： | 1 |
| 11 | Isobaric vapor-liquid equilibria of the water + 2-propanol system at 30,60, and 100 kPa显示文摘 | Marzal P Montn J B Rodrigo M A | 1996 | J Chero Eng Data1996，41，： | 1 |
| 12 | Palladium and Mo-lybdenum Mono and Bimetallic Catalysts on Modernitefor Direct NO Decomposition Reaction显示文摘 | Rodrigo S Andréa M Sibele B etc | 2009 | Catalysis Let-ters2009，129，34： | 1 |
| 13 | Fast electrochromic response of ultraporous polyaniline nanofibers显示文摘 | EUSTAQUIO M E ANA M B RODRIGO A I | 2014 | Polymer2014，55，10： | 1 |
| 14 | Molecular and functional characterization of a novel ehromoplast-specific lycopene β-cyclase from Citrus and its relation to lycopene accumulation显示文摘 | ALUEEZAR B ZACARIAS L RODRIGO M J | 2009 | J Exp Bot2009，60，6： | 1 |
| 15 | Biotransformation of digitoxigenin by Fusarium ciliatum显示文摘 | Pádua Rodrigo M Oliveira Alaíde B Souza Filho José D | 2005 | J Braz Chem Soc2005，16，3： | 1 |
| 16 | Metabolite identification in human liver needle biopsies by high-resolution magic angle spinning ^1H NMR spectroscopy 显示文摘 | Martinez Granados B Monleon D Martinez-Bisbal M C Rodrigo J M del Olmo J Lluch P | 2006 | NMR Biomed2006，19，： | 1 |
| 17 | Synthesis and antimalarial activity of semicarbazone and thiosemicarbazone derivatives 显示文摘 | Renata B O Elaine M S F Rodrigo P P S | 2008 | Eur J Med Chem2008，43，： | 1 |
| 18 | Simulation of a Mixed-Cell Raceway Using Computational Fluid Dynamics (CFD)显示文摘 | RODRIGO A L MICHAEL B T JAMES M E | | 0，，： | 1 |
| 19 | Early apoptosis in peripheral blood mononuclear cells from patients with bipolar disorder显示文摘 | Gabriel Rodrigo Fries Mirela Paiva Vasconcelos-Moreno Carolina Gubert Barbara Tietb?hl Martins Quadros dos Santos André Luiz Schuh Teixeira da Rosa Bárbara Eisele Juliana Sartori Bianca Pfaffenseller Flávio Kapczinski Márcia Kauer-Sant’Anna | 2014 | Journal of Affective Disorders2014，，： | 1 |
| 20 | Fuzzy modeling of farmers'knowledge for land suitability classification显示文摘 | RODRIGO S S EMMANUEL J M C UDAY B N | 2005 | Agricultural Systems2005，83，： | 1 |
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