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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Factors that impact health-related quality of life in adults with celiac disease:A multicenter study显示文摘AIM: To evaluate the factors involved in the impairment of health-related quality of life (HRQOL) in patients with celiac disease.METHODS: A multicenter, cross-sectional prospective study was performed in patients with celiac disease who completed two HRQOL questionnaires: the gastrointestinal quality of life index (GIQLI) and the EuroQol-5D (EQ).RESULTS: Three hundred and forty patients (163 controlled with a gluten-free diet, and 177 newly diagnosed with a normal diet) were included. The GIQLI score was significantly better in patients on a gluten-free diet (GFD) than in non-treated patients on their usual diet, both in terms of the overall score (3.3 vs 2.7, respectively; P < 0.001), as well as on the individual questionnaire dimensions. Both the preference value of the EQ as the visual analogue scale were significantly better in treated than in non-treated patients (0.93 vs 0.72 P < 0.001 and 80 vs 70 P < 0.001, respectively). Variables significantly associated with a worse HRQOL score were female gender, failure to adhere to a GFD, and symptomatic status.CONCLUSION: In untreated celiac disease, the most important factors that influence patient perception of health are the presence of symptoms and a normal diet. HRQOL improves to levels similar to those described in the general population in celiac disease patients well controlled with a GFD. | F Casellas L Rodrigo J López Vivancos S Riestra C Pantiga JS Baudet F Junquera V Puig Diví C Abadia M Papo J Gelabert JR Malagelada | 2008 | World Journal of Gastroenterology2008，14，1： | 2 |
| 3 | Calcitonin gene- related peptide in cardiovascular tissue of the rat显示文摘 | Mulderry P K Ghatei M A Rodrigo J | 1985 | Neuro- science1985，14，9： | 1 |
| 4 | Experimental implementation of the gyrator transform 显示文摘 | RODRIGO J A AIAEVA T CALVO M L | 2007 | Journal of Optics Society of America A2007，24，10： | 1 |
| 5 | Clusterin expression is associ- ated with decreased disease-free survival of patients with colorectal carcinomas 显示文摘 | Redondo M Rodrigo I Alcaide J | 2010 | Histopathology2010，56，7： | 1 |
| 6 | Characterization of Pinalate, a novel Citrus sinensis mutant with a fruit-specific alteration that results in yellow pigmentation and decreased ABA content显示文摘 | Rodrigo M J Marcos J F Alferez F | 2003 | J Exp Bot2003，54，： | 1 |
| 7 | Production of electricity from the treatment of urban wastewater using a microbial fuel cell显示文摘 | Rodrigo M A Canizares P Lobato J | 2007 | Journal of Power Sources2007，169，1： | 1 |
| 8 | Analysis of evacuation strategies for design and certification of transport airplanes显示文摘 | RODRIGO M V HEDO J M | 2000 | J of Aircraft2000，37，3： | 1 |
| 9 | Production of electricity from the treatment of urban waste water using a microbial fuel cell 显示文摘 | Rodrigo M A Canizares P Lobato J | 2007 | J Power Sources2007，169，1： | 1 |
| 10 | Evolutionary analysis of the picornavirus family 显示文摘 | Rodrigo M J Dopazo J | 2002 | J Mol Evol2002，40，： | 1 |
| 11 | A nanoindentation technique for functional evaluation of cartilage repair tissue显示文摘 | Ebenstein D M Kuo Alfred Rodrigo J J etal | 2004 | J Mater Res2004，19，1： | 1 |
| 12 | Operation of a horizontal subsurface flow constructed wetland-microbial fuel cell treating wastewater under different organic loading rates 显示文摘 | Villasefior J Capilla P Rodrigo M A | 2013 | Water Re- search2013，47，17： | 1 |
| 13 | Effect of the Current Intensity in the Electrochemical Oxidation of Aqueous Phenol Wastes at an Activated Carbon and Steel Anode显示文摘 | Canizares P Domlnguez J A Rodrigo M A | 1999 | Ind Eng Chem Res1999，38，： | 1 |
| 14 | Use of polarography as a quality-control method for determining diacetyl in citrus and vegetable juices,yoghurt and butter显示文摘 | Esteve M J Frígola A Rodrigo M C | 2002 | Food Additives and Contaminants2002，19，6： | 1 |
| 15 | Changes of colour and carotenoids contents during high intensity pulsed electric field treatment in orange juices显示文摘 | Cortes C Esteve M J Rodrigo D | 2006 | Food and Chemical Toxicology2006，44，11： | 1 |
| 16 | Influence of lanthanum oxide as quality promoter on cathodes for MCFC显示文摘 | Escudero M J Novoa X R Rodrigo T | 2002 | Journal of Power Sources2002，106，12： | 1 |
| 17 | Energy saving in the aeration process by fuzzy logic control显示文摘 | Fewer J Rodrigo M A Seeo A | 1998 | Water Science Teeh1998，38，3： | 1 |
| 18 | Identification and partial characterization of the soybean-dust allergens involved in the Barcerona asthma epidemic 显示文摘 | Rodrigo M J Morell F Helm R M | 1990 | Allergy and Clinical Immunology1990，85，： | 1 |
| 19 | Electrochemical treatment of 2,4-dinitrophenol aqueous wastes using boron-doped diamond anodes显示文摘 | P Canizares C Saez J Lobato M A Rodrigo | 2004 | Electrochimica Acta2004，49，： | 1 |
| 20 | Production of electricity from the treatment of urban waste water using a microbial fuel cell显示文摘 | Rodrigo M A Canizares P Lobato J | | 0，，01： | 1 |
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