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| 1 | Postpartum depression:A systematic review of the genetics involved显示文摘Postpartum depression is one of the most prevalent psychopathologies. Its prevalence is estimated to be between 10% and 15%. Despite its multifactorial etiology, it is known that genetics play an important role in the genesis of this disorder. This paper reviews epidemiological evidence supporting the role of genetics in postpartum depression(PPD). The main objectives of this review are to determine which genes and polymorphisms are associated with PPD and discuss how this association may occur. In addition, this paper explores whether these genes are somehow related to or even the same as those linked to Major Depression(MD). To identify gaps in the current knowledge that require investigation, a systematic review was conducted in the electronic databases Pub Med, LILACS and Sci ELO using the index terms 'postpartum depression' and 'genetics'. Literature searches for articles in peerreviewed journals were made until April 2014. PPD was indexed 56 times with genetics. The inclusion criteria were articles in Portuguese, Spanish or English that were available by institutional means or sent by authors upon request; this search resulted in 20 papers. Genes and polymorphisms traditionally related to MD, which are those involved in the serotonin, catecholamine, brain-derived neurotrophic factor and tryptophan metabolism, have been the most studied, and some have been related to PPD. The results are conflicting and some depend on epigenetics, which makes the data incipient. Further studies are required to determine the genes that are involved in PPD and establish the nature of the relationship between these genes and PPD. | Tiago Castro e Couto Mayra Yara Martins Brancaglion António Alvim-Soares Lafaiete Moreira Frederico Duarte Garcia Rodrigo Nicolato Humberto Corrêa Regina Amélia Lopes P Aguiar Henrique Vitor Leite | 2015 | World Journal of Psychiatry2015，5，1： | 5 |
| 2 | Pentoxifylline 通过 TNF- 合成和 TGF-1 基因表示的下面规定改进肝新生显示文摘 AIM:To investigate the mechanism of pentoxifylline(PTX)improvement in liver regeneration.RESULTS:Rats were randomized into 4 groups:Control rats;Sham-sham-operation rats;Saline-70% hepatectomy plus saline solution;PTX-70%hepatectomy plus PTX.At 2 and 6 h after hepatectomy,aspartate aminotransferase,alanine aminotransferase,tumor necrosis factor(TNF)-α and interleukin-6(IL-6)serum and hepatic tissue levels were determined.Tumor growth factor(TGF)-β1 gene expression in liver tissue was evaluated 24 h after hepatectomy by quantitative reverse transcriptase polymerase chain reaction analysis.Proliferation was analyzed by mitotic index and proliferating cell nuclear antigen(PCNA)staining 48 h after hepatectomy.RESULTS:TNF-α and IL-6 serum levels increased at 2 and 6 h after hepatectomy.At 2 h after hepatectomy serum PTX was reduced but not hepatic levels of TNF-α and IL-6.A decrease in liver TGF-β1 gene expression and an increase in mitotic index and PCNA after hepatectomy were observed in the PTX treatment group in comparison to the saline group.CONCLUSION:PTX improves liver regeneration by a mechanism related to down regulation of TNF-α production and TGF-β1 gene expression. | Rodrigo Bronze Martino Ana Maria Mendona Coelho Márcia Saldanha Kubrusly Regina Leito Sandra Nassa Sampietre Marcel Cerqueira Cesar Machado Telesforo Bacchella Luiz Augusto Carneiro D’Albuquerque | 2012 | World Journal of Gastrointestinal Surgery2012，4，6： | 2 |
| 3 | Brain Region-Selective Mechanisms Contribute to the Progression of Cerebral Alterations in Acute Liver Failure in Rats显示文摘 | Omar Cauli Pilar López–Larrubia Regina Rodrigo Ana Agusti Jordi Boix Laura Nieto–Charques Sebastián Cerdán Vicente Felipo | 2011 | Gastroenterology2011，，2： | 1 |
| 4 | Chronic hyperammonemia reduces the activity of neuronal nitric oxide synthase in cerebellum by altering its localization and increasing its phosphorylation by calcium- calmodulin kinase Ⅱ 显示文摘 | E1-Mlili Nisrin Rodrigo Regina Naghizadeh Bahareh | 2008 | J Neurochem2008，106，3： | 1 |
| 5 | Cerebral oedema is not responsible for motor or cognitive deficits in rats with hepatic encephalopathy显示文摘 | Omar Cauli Marta Llansola Ana Agustí Regina Rodrigo Vicente Hernández‐Rabaza Tiago B. Rodrigues Pilar López‐Larrubia Sebastián Cerdán Vicente Felipo | 2014 | Liver Int2014，，3： | 1 |
| 6 | Brazilian Football: What Brings Fans to the Game? 显示文摘 | Regina Madalozzo Rodrigo Berber Villar | 2009 | Journal of Sports Economics2009，10，6： | 1 |
| 7 | Brazilian football: What brings fans to the game? 显示文摘 | Regina Madalozzo Rodrigo Berber Villar | 2009 | Journal of Sports Economics2009，10，6： | 1 |
| 8 | Cyclic GMP pathways in hepatic encephalopathy. Neurological and therapeutic implications显示文摘 | Carmina Montoliu Regina Rodrigo Pilar Monfort Marta Llansola Omar Cauli Jordi Boix Nisrin ElMlili Ana Agusti Vicente Felipo | 2010 | Metabolic Brain Disease2010，，1： | 1 |
| 9 | NMDAreceptors in hyperammonemia and hepatic encephalopathy 显示文摘 | Marta Llansola Regina Rodrigo Pilar Monfort | 2007 | Metab Brain Dis2007，22，34： | 1 |
| 10 | Concepts of biological rhythmicity and chronobiology in the Holy Bible显示文摘Dear editors,The way in which religious texts and sources depict the processes involved in the regulation of life is an interesting and rich topic.For example,the Holy Bible,the religious basis of Western civilization,is a document that | Rodrigo Luiz Vancini Marília dos Santos Andrade Cássia Regina Vancini-Campanharo Claudio Andre Barbosa de Lira | 2015 | Journal of Integrative Medicine2015，13，5： | 0 |
| 11 | Phosphate-activated glutaminase activity is enhanced in brain, intestine and kidneys of rats following portacaval anastomosis显示文摘瞄准:估计在老鼠的门腔静脉吻合(PCA ) 是否在肾影响蛋白质表示或谷酰胺酶的活动,肠并且在外皮的三个大脑区域,基础轧了神经胶质和小脑并且解释在肝的脑病发现的神经病学的改变(他) 。方法:称 250-350 g 的十六只男 Wistar 老鼠被组织进假冒操作的控制(n=8 ) 或 portacaval (n=8 ) 。在过程以后的 28 天,动物被牺牲。十二指肠,肾和大脑被移开, homogenised 和线粒体被孤立。氨在大脑和血被测量。激活磷酸盐的谷酰胺酶(PAG ) 活动被与 O-phthalaldehyde (OPA ) 和每蛋白质(蛋白质的 mukat/g ) 的克以单位表示的特殊活动在 37 摄氏度测量氨生产追随者孵化一个小时决定。蛋白质表示被弄污的免疫测量。结果:十二指肠并且和蛋白质内容的肾 PAG 活动比在 PCA 组是显著地更高的在控制或假冒操作老鼠(十二指肠 PAG 活动是在 PCA 老鼠对在假冒操作老鼠的蛋白质的 429.19+/-126.92mukat/g 的蛋白质的 976.95+/-268.87 mukat/g;肾 PAG 活动是在 PCA 老鼠对在控制的蛋白质的 669.67+/-400.8 mukat/g 的 1259.18+/-228.79 mukat/g 蛋白质, P<0.05;十二指肠的蛋白质内容:173% 在 PCA 对假冒操作老鼠;在肾,蛋白质的内容在 PCA 对假冒操作老鼠是 152%) 。在 PCA 老鼠的 PAG 活动和蛋白质表示在外皮是更高的并且基础在假冒操作老鼠比那些轧了神经胶质(外皮:蛋白质的 6646.6+/-1870.4 mukat/g 对在控制老鼠的蛋白质的 3573.8+/-2037.4 mukat/g, P<0.01;基础轧了神经胶质, PAG 活动是在 PCA 老鼠对在假冒的操作老鼠的蛋白质的 2271.2+/-384 mukat/g 的蛋白质的 3657.3+/-1469.6 mukat/g, P<0.05;在小脑,分别地, PAG 活动是蛋白质的 2471.6+/-701.4 mukat/g 对在 PCA 和假冒的老鼠的蛋白质的 1452.9+/-567.8 mukat/g P<0.05;蛋白质的内容:大脑皮质:162%+/-40% 对 100%+/-26% , P<0.009;并且基础轧了神经胶质:140%+/-39% 对 100%+/-14% , P<0.05;然而并非在里面小脑:100%+/-25% 对 100%+/-16% , P=ns ) 。结论:在肾和十二指肠的增加的 PAG 活动能在 PCA 老鼠显著地作出贡献到 hyperammonaemia,脑病的动物模型。PAG 从外皮在 non-synaptic 线粒体被增加并且基础轧了神经胶质并且能在肝的脑病的致病被含有。因此, PAG 能是为处理的一个可能的目标他或肝机能障碍。 | Manuel Romero-Gómez María Jover Daniel Díaz-Gómez Laura Collantes de Terán Regina Rodrigo Inés Camacho Miriam Echevarría Vicente Felipo Juan D Bautista | 2006 | World Journal of Gastroenterology2006，12，15： | 0 |
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