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| 1 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 2 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 3 | Particle packing in loess deposits and the problem of structure collapse and hydroconsolidation 显示文摘 | DIJKSTRA T A SMALLEY I J ROGERS E D F | 1995 | Engi- neering Geology1995，40，： | 1 |
| 4 | Mechanistic approach to predict real machining time for milling free- form geometries applying high feed rate显示文摘 | COELHO R T SOUZA A F ROGER A R | 2010 | International Journal of Advanced Manufacturing Technology2010，46，9101112： | 1 |
| 5 | Mesoporous tin oxides as lithium intercalation anode materials 显示文摘 | YU A ROGER F | 2002 | J Power Sources2002，104，1： | 1 |
| 6 | Growing Hot Pepper for Cabbage Looper, Trichopulsia ni (Hubner) and Spidermite, Tetranychus urticae (Koch) Control显示文摘 | ANTONIOUS G F MEYER J E ROGERS J A | 2007 | Journal of Environmental Science and Health-part B Pesticides Food Contaminants and Agricultural Wastes2007，42，5： | 1 |
| 7 | A new method for improved hub height mean wind speed estimates using short-term hub height data显示文摘 | Lackner M A Rogers A L Manwell J F | 2010 | Renewable Energy2010，35，10： | 1 |
| 8 | Old and undertriaged:a lethal combination显示文摘 | Rogers A Rogers F Bradburn E | 2012 | Am Surg2012，78，6： | 1 |
| 9 | Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole ST Brosch R Parkhill J Garnier T Churcher C Harris D Gordon SV Eiglmeier K Gas S Barry CE Tekaia F Badcock K Basham D Brown D Chillingworth T Connor R Davies R Devlin K Feltwell T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Krogh A Mclean J Moule S Murphy L Oliver K Osborne J Quail MA Rajandream MA Rogers J Rutter S Seeger K Skelton J Squares R Squares S Sulston JE Taylor K Whitehead S Barrell BG | 1998 | Nature1998，393，6685： | 1 |
| 10 | 查看详情显示文摘 | Iglesias C A Rogers F J | | 0，，： | 1 |
| 11 | Summer dormancy, regeneration and persistence of perennial grasses in south-western Australia 显示文摘 | Biddiscombe E F Rogers A L Mallers R A | 1977 | Journal of Experimental Agriculture and Animal Husbandry1977，17，： | 1 |
| 12 | Formation and cot, lapse of metastable particle packings and open structure in loess deposits显示文摘 | Assallay A M Rogers C D F Smatley I J | 1997 | Engeering Geology1997，48，12： | 1 |
| 13 | Comparison of three enoate reduetases and their potential use for biotransformations显示文摘 | CHAPARRO-RIGGERS J F ROGERS T A VAZQUEZ- FIGUEROA E | 2007 | Advanced synthesis and catalysis2007，349，89： | 1 |
| 14 | Generation of photon energy deposition kernels using the EGS Monte Carlo code显示文摘 | Mackie T R Bielajew A F Rogers D W | 1988 | Phys Med Biol1988，33，1： | 1 |
| 15 | 查看详情显示文摘 | Rogers F J Swenson F J Iglesias C A | | 0，，： | 1 |
| 16 | Engineering properties of lo-ess in Libya 显示文摘 | Assallay A M Rogers C D F Smalley I J | 1996 | Journal of Arid Environments1996，32，4： | 1 |
| 17 | Evaluation of the ATB 32 E system for automated i- dentification of Enterobacteriaceae 显示文摘 | Roger F Roger A | 1992 | Pathol Biol1992，，1： | 1 |
| 18 | Composition ofa ch- emopreventive proanthocyanidin-rich fraction from cranberry fruits responsible for the inhibition of 12-O-tetradecanoyl Pho- rbol-β-aeetate (TPA) induced ornithine decarboxylase (ODC) activity显示文摘 | Kandil F E Smith M A L Rogers R B | 2002 | Journal of Agricultural and Food Chemistry2002，50，5： | 1 |
| 19 | Numerical and experimental study of arc and weld pool hehaviour for pulsed current GTA welding 显示文摘 | TRAIDIA A ROGER F | 2011 | International Journal of Heat and Mass Transfer2011，54，910： | 1 |
| 20 | Engineering Properties of Loess in Libya 显示文摘 | ASSALLAY A M ROGERS C D F SMALLEY I J | 1996 | Journal of Arid Environments1996，32，4： | 1 |
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