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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | 显示文摘 | Luis da S Z Ronaldo D M Rogerio | 2002 | Vacuum2002，65，： | 1 |
| 3 | Effect of impeller type and mechanical agitation on the mass transfer and power consumption aspects of ASBR operation treating synthetic wastewater显示文摘 | Michelan Rogerio Zimmer Thiago R Rodrigues Jose A D | 2009 | Journal of Environmental Management2009，90，3： | 1 |
| 4 | Copper chloride contamination influence on the shear strength of soils used as liners 显示文摘 | Silva E Pacheco D Rogerio E E | 2005 | Solos e Rochas2005，28，3： | 1 |
| 5 | Sepsis: from bench to bedside显示文摘 | Eliezer S Rogerio D Hora P | 2008 | Clinics2008，63，1： | 1 |
| 6 | Molecular characterization of vitellin from the ovaries of the white shrimp Penaeus (Litopenaeus) vannamei 显示文摘 | GARC VARGAS-ALBORES F ROGERIO R S M | 2002 | Comparative Biochemistry and Physiology2002，133，3： | 1 |
| 7 | Effects of leucine supplementation on the body composition and protein status of rats submitted to food restriction显示文摘 | Jose D Rogerio G P Vinicius F C | 2006 | Nutrition2006，22，5： | 1 |
| 8 | Effect of impeller type and mechanical agitation on the mass transfer and power consumption aspects of ASBR operation treating synthetic waste water显示文摘 | Rogerio M Thiago R Z Jose A D | 2009 | Journal of Environmental Management2009，90，5： | 1 |
| 9 | Wa- ter cooling system using a piezoelectrically actuated flow pump for a medical headlight system显示文摘 | Rogerio F P Sandro L V Amaury R D O | 2008 | Pro- ceedings of SPIE2008，6527，： | 1 |
| 10 | Optimum generation control in wind parks when carrying out system operator requests显示文摘 | Rogerio G de A Edgardo D C | 2006 | IEEE Transactions onPowerSystems2006，21，2： | 1 |
| 11 | Parti-cipation of Doubly Fed Induction Wind Generators in System Frequency Regulation显示文摘 | ROGERIO G ALMEDIA D PEACAS LOPES J A | 2007 | IEEE Transactions on Power Systems2007，22，3： | 1 |
| 12 | Participation of doubly fed induction wind generators in system frequency regulation显示文摘 | Rogerio G Almeida D Peas Lopes J A | 2007 | IEEE Transactions on Power Systems2007，22，3： | 1 |
| 13 | Effect of impeller type and mechanical agitation on the mass transfer and power consumption aspects of ASBR operation treating synthetic wastewater显示文摘 | Rogerio Miehelan Thiago R Zimmer Jose A D Rodrigues Suzana M Ratusznei Deovaldo de Maraes Marcelo Zaiat Eugenio Foresti | 2009 | Journal of Environmental Management2009，90，： | 1 |
| 14 | Serum transforming growth factor beta-1 (TGF-beta-1) lev-els in diabetic patients are not associated with pre-existent coro-nary artery disease显示文摘 | Beatriz D Schaan Alexandre S Quadros Rogerio Sarmento-Leite | 2007 | Cardiovascular Diabetology2007，6，12： | 1 |
| 15 | Silicon nitride deposited by inductively coupled plasma using silane and nitrogen 显示文摘 | LUIS S Z RONALDO D M ROGERIO F | 2002 | Vacuum2002，65，： | 1 |
| 16 | Participation of doubly fed induction wind generators in system frequency regulation 显示文摘 | G Rogerio D Almeida J A Pefas Lopes | 2007 | IEEE Transactions on Power systems2007，22，3： | 1 |
| 17 | Degradation of Dimethyl Disulfide Using Homogeneous Fenton's Reaction显示文摘 | Roberta L K Rogerio M D Marco D L | 2009 | Journal of Hazardous Materials2009，169，： | 1 |
| 18 | Effect of impeller type and mechanical agitation on the masstransfer and power consumption aspects of ASBR operation treatingsynthetic wastewater显示文摘 | Rogerio Michelan Thiago R Zimmer Jose A D Rodrigues | 2009 | Journal of Environmental Management2009，90，3： | 1 |
| 19 | Optimum generation control in wind parks when carrying out system operator requests显示文摘 | Rogerio A Edgardo D C Pecas J A | 2006 | IEEE Transactions on Power Systems2006，21，2： | 1 |
| 20 | Depositional and di- agenetic controls on the reservoir quality of Lower Cretaceous Pendencial Sandstones,Potiguar Rift Basin,Brazil显示文摘 | Sylvia M C Luiz F D Rogerio S D | 2000 | AAPG Bulletin2000，84，11： | 1 |
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