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| 1 | Prognostic value of ^(18)F-FDG PET/CT in liver transplantation for hepatocarcinoma显示文摘AIM:To evaluate the prognostic value of pretreatment F D G p o s i t r o n e m i s s i o n t o m o g ra p h y c o m p u t e d tomography(PET-CT) in patients with hepatocarcinoma treated by liver transplantation(LT).METHODS:The authors retrospectively analyzed the data of 27 patients(mean age 58 ± 9 years) who underwent FDG PET-CT before LT for hepatocarcinoma.Mean follow-up was 26 ± 18 mo.The FDG PET/CT was performed according to a standard clinical protocol:4 MBq FDG/kg body weight,uptake 60 min,low-dose non-enhanced CT.The authors measured the SUVmax and SUVmean of the tumor and the normal liver.The tumor/liver activity ratios(RSUVmax and RSUVmean) were tested as prognostic factors and compared to the following conventional prognostic factors:MILAN,CLIP,OKUDA,TNM stage,alphafoetoprotein level,portal thrombosis,size of the largest nodule,tumor differentiation,microvascular invasion,underlying cirrhosis and liver function.RESULTS:Overall and recurrence free survivals were80.7%and 67.4%at 3 years,and 70.6%and 67.4%at 5 years,respectively.According to a multivariate Cox model,only FDG PET/CT RSUVmax predicted recurrence free survival.Even though the MILAN criteria alone were not predictive,it is worth noting that none of the patients outside the MILAN criteria and with RSUVmax<1.15 relapsed.CONCLUSION:FDG PET/CT with an RSUVmax cutoff value of 1.15 is a strong prognostic factor for recurrence and death in patients with HCC treated by LT in this retrospective series.Further prospectivestudies should test whether this metabolic index should be systematically included in the preoperative assessment. | Olivier Detry Laurence Govaerts Arnaud Deroover Morgan Vandermeulen Nicolas Meurisse Serge Malenga Noella Bletard Charles Mbendi Anne Lamproye Pierre Honoré Paul Meunier Jean Delwaide Roland Hustinx | 2015 | World Journal of Gastroenterology2015，21，10： | 5 |
| 2 | 18F-FDG PET imaging of rheumatoid knee synovitis correlates with dynamic magnetic resonance and sonographic assessments as well as with the serum level of metalloproteinase-3显示文摘 | Catherine Beckers Xavier Jeukens Clio Ribbens Béatrice André Stefaan Marcelis Philippe Leclercq Marie-Jo?lle Kaiser Jacqueline Foidart Roland Hustinx Michel G. Malaise | 2006 | European Journal of Nuclear Medicine and Molecular Imaging2006，，3： | 1 |
| 3 | 18-Fluoro-deoxyglucose uptake in inflammatory hepatic adenoma:A case report显示文摘Positron emission tomography computed tomography(PET-CT) using ^(18)-Fluoro-deoxyglucose(^(18)FDG) is an imaging modality that reflects cellular glucose metabolism. Most cancers show an uptake of ^(18)FDG and benign tumors do not usually behave in such a way. The authors report herein the case of a 38-year-old female patient with a past medical history of cervical intraepithelial neoplasia and pheochromocytoma, in whom a liver lesion had been detected with PET-CT. The tumor was laparoscopically resected and the diagnosis of inflammatory hepatic adenoma was confirmed. This is the first description of an inflammatory hepatic adenoma with an ^(18)FDG up-take. | Willy Liu Jean Delwaide Noella Bletard Philippe Delvenne Paul Meunier Roland Hustinx Olivier Detry | 2017 | World Journal of Hepatology2017，9，11： | 1 |
| 4 | Positron emission tomography imaging for lymphoma显示文摘 | Guy Jerusalem Roland Hustinx Yves Beguin Georges Fillet | 2005 | Current Opinion in Oncology2005，，： | 1 |
| 5 | Positron emission tomography imaging for lymphoma显示文摘 | Guy Jerusalem Roland Hustinx Yves Beguin Georges Fillet | 2005 | Current Opinion in Oncology2005，，5： | 1 |
| 6 | Whole-body FDG-PET imaging in the management of patients with cancer显示文摘 | Roland Hustinx Fran?ois Bénard Abass Alavi | 2002 | Seminars in Nuclear Medicine2002，，1： | 1 |
| 7 | FDG PET/CT in Crohn’s disease: correlation of quantitative FDG PET/CT parameters with clinical and endoscopic surrogate markers of disease activity显示文摘 | Babak Saboury Ali Salavati Alex Brothers Sandip Basu Thomas C. Kwee Marnix G. E. H. Lam Roland Hustinx Edouard Louis Drew A. Torigian Abass Alavi | 2014 | European Journal of Nuclear Medicine and Molecular Imaging2014，，： | 1 |
| 8 | Toward diagnostic relevance of theαVβ5,αVβ3,andαVβ6 integrins in OA:expression within human cartilage and spinal osteophytes显示文摘We previously reported 18FPRGD2 uptake by the coxofemoral lining,intervertebral discs and facet joint osteophytes in OA using PET/SCAN imaging.However,the molecular mechanism by which the PRGD2 tracer interacts with joint tissues and osteophytes in OA remains unclear.As PRGD2 ligands are expected to belong to the RGD-specific integrin family,the purpose of this study was(i)to determine which integrin complexes display the highest affinity for PRGD2-based ligands,(ii)to analyze integrin expression in relevant tissues,and(iii)to test integrin regulation in chondrocytes using OA-related stimuli to increase the levels of fibrosis and ossification markers.To this end,the affinity of PRGD2-based ligands for five heterodimeric integrins was measured by competition with 125I-echistatin.In situ analyses were performed in human normal vs.OA cartilage and spinal osteophytes.Osteophytes were characterized by(immuno-)histological staining.Integrin subunit expression was tested in chondrocytes undergoing dedifferentiation,osteogenic differentiation,and inflammatory stimulation.The integrinsαVβ5,αVβ3,andαVβ6 presented the highest affinity for PRGD2-based ligands.In situ,the expression of these integrins was significantly increased in OA compared to normal cartilage.Within osteophytes,the mean integrin expression score was significantly higher in blood vessels,fibrous areas,and cells from the bone lining than in osteocytes and cartilaginous zones.In vitro,the levels of integrin subunits were significantly increased during chondrocyte dedifferentiation(except forβ6),fibrosis,and osteogenic differentiation as well as under inflammatory stimuli.In conclusion,anatomical zones(such as OA cartilage,intervertebral discs,and facet joint osteophytes)previously reported to show PRGD2 ligand uptake in vivo expressed increased levels ofαVβ5,αVβ3,andβ6 integrins,whose subunits are modulated in vitro by OA-associated conditions that increase fibrosis,inflammation,and osteogenic differentiation.These results suggest that the increased levels of integrins in OA compared to normal tissues favor PRGD2 uptake and might explain the molecular mechanism of OA imaging using the PRGD2-based ligand PET/CT. | Edith Charlier Céline Deroyer Sophie Neuville Zelda Plener Olivier Malaise Federica Ciregia Philippe Gillet Gilles Reuter Mallory Salvé Nadia Withofs Roland Hustinx Dominique de Seny Michel G.Malaise | 2020 | Bone Research2020，8，4： | 1 |
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