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| 1 | Intralesional steroid is beneficial in benign refractory esophageal strictures:A meta-analysis显示文摘AIM To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures.METHODS A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and Laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment tools.RESULTS Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(MD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(MD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SMD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid injection.CONCLUSION Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research. | László Szapáry Benedek Tinusz Nelli Farkas Katalin Márta Lajos Szakó Agnes Meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra Mikó Dezso Csupor Péter Hegyi Balint Eross | 2018 | World Journal of Gastroenterology2018，24，21： | 7 |
| 2 | Cytokerat in 20 in human carcinoma显示文摘 | Roland M Adrea L Jurgen L | 1992 | Am J Path1992，140，： | 1 |
| 3 | ICAM-1 expression deter- mines malignant potential of cancer 显示文摘 | Roland C L Harken A H Sarr M G | 2007 | Surgery2007，141，6： | 1 |
| 4 | Blocking GABA-A receptors inthe medial septum enhances hippocampal acetylcholine releaseand behavior in a rat model of diencephalic amnesia显示文摘 | ROLAND J J SAVAGE L M | 2009 | Phar-macol Biochem Behav2009，92，： | 1 |
| 5 | Surface spectroscopic characterization of cobalt-molybdenum-alumina catalysts 显示文摘 | Roland L Chin David M Hercules | 1982 | Phys Chem1982，86，： | 1 |
| 6 | Models for the component dynamics in blends and mixtures显示文摘 | NGAI K L ROLAND C M | 2004 | Molecular Crystals and Liquid Crystals2004，77，3： | 1 |
| 7 | Nutrient-chlorophyll relationships in tropical-subtropical lakes:do temperate models fit?显示文摘 | Huszar V L M Caraco N F Roland F | 2006 | Biogeochemistry2006，79，12： | 1 |
| 8 | The application of the energy landscape model to polymers显示文摘 | Roland C M Santangelo P G Ngai K L | | 0，，： | 1 |
| 9 | Single - dose, extendedrelease epidural morphine(DepoDur)compared to con- ventional epidural morphine for post - cesarean pain 显示文摘 | Carvalho B Roland L M Chu L F | 2007 | Anesth Analg2007，105，1： | 1 |
| 10 | Development of a Combined Sex Pheromone-based Monitoring System for Malacosoma disstria (Lepidoptera:Lasoicampidae) and Choristoneura conflictana (Lepidoptera:Tortricidae)显示文摘 | JONES B C ROLAND J EVENDEN M L | 2009 | Environmental Entomology2009，38，2： | 1 |
| 11 | Random amplified polymorphic DNA markers: A system for identifying and differentiating isolates of Collectotrichum graminicola显示文摘 | CHEN X M ROLAND F L LEUNG H | 1993 | Phytopathology1993，83，12： | 1 |
| 12 | A comparison of segmental dynamics in polymer by solid-state ^13C NMR spectroscopy显示文摘 | Mcgrath K J Ngai K L Roland C M | 1995 | Macromolecules1995，28，： | 1 |
| 13 | Automatic image annotation using visual content and folksonomies显示文摘 | Stefanie L Roland M Robert S | | 0，，01： | 1 |
| 14 | Specific systemic antioxi- dant response to preeclampsia in late pregnancy: the study of intracellular glutathione peroxidases in maternal and fetal blood 显示文摘 | Boutet M Roland L Thomas N | 2009 | Am J Obstet Gynecol2009，200，5： | 1 |
| 15 | Determination of absorption characteristics of AG337, a novel thymidylate synthase inhibitor, using a perfused rat intestinal model显示文摘 | HU M ROLAND K GE L | 1998 | J Pharm Sci1998，87，7： | 1 |
| 16 | Determination of absorption characteristics of AG337, a novel thymidylate synthase inhibitor, using a perfused rat intestinal model 显示文摘 | Hu M Roland K Ge L | 1998 | J Pharm Sci1998，87，： | 1 |
| 17 | Promotion of tumor growth by murine fibroblast activation protein, a sefine protease, in an animal model显示文摘 | Jonathan D Cheng Roland L Valianou M | 2002 | Cancer Res2002，62，16： | 1 |
| 18 | Automatic image annotation using visual content and folksonomies显示文摘 | Stefanie L Roland M Robert S | 2009 | Multimedia Tools and Applications2009，42，： | 1 |
| 19 | The human keratins:biology and pathology显示文摘 | Roland M Markus D Lutz L | 2008 | Histochem Cell Biol2008，129，： | 1 |
| 20 | Gene action in wheat cultivars for Durable,high-Temperature ,Adult-Plant Resistance and interaction with racespecific ,seedling resistance to puccinia striiformis显示文摘 | Chen X M Roland F L | 1995 | Genetics1995，85，5： | 1 |
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